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    Elective pneumonectomy for non-small cell lung cancer: Factors affecting early operative mortality and morbidity
    (Acta Medical Belgica, 2006) Karamustafaoglu, Y. A.; Haciibrahimoglu, G.; Fazlioglu, M.; Olcmen, A.; Kutlu, C. A.; Gurses, A.; Bedirhan, M. A.
    Background : The aim of this study was to investigate the factors influencing the morbidity and mortality of the non-small cell lung cancer (NSCLC) cases where pneumonectomy was performed. Material & methods: All 101 patients who had underwent a pneumonectomy for NSCLC between 1994-2001 in our hospital were included in the retrospective study. There were 97 males and 4 females with a mean age of 56 +/- 9.6. Factors affecting morbidity and mortality were analysed by univariate and multivariate analysis. Results: The morbidity rate was 53% and the mortality rate was 9%. Morbidity was related to cardiopulmonary complications in 40% of the cases. The risk factors for cardiopulmonary morbidity with univariate analysis were age >60 years (p = 0.004), FEV1 < 2 It (p = 0.016), early bronchopleural fistula (p = 0.0001), tumour size >4 cm (p = 0.033), vital capacity <3.7 It (p = 0.016), forced vital capacity <3.5 It (p = 0.033). With multivariate analysis the risk factors cardiopulmonary morbidity were age (60 >) (p = 0.012) and tumour size > 4 ern (p = 0.043). The risk factors mortality with univariate analysis were right pneumonectomy (p = 0.025), respiratory morbidity (p = 0.0001), cardiac morbidity (p = 0.002), cell type (Epidermoid CA) (0.047), tumour size > 6 cm (p = 0.036), fluid infusion (p = 0.009), forced vital capacity <78% (p = 0.039), forced expiratory volume in I second <75% (p = 0.039), PO2 (p = 0.037), PCO2 >42 mmHg (p = 0.023). Conclusion : Among the pneumonectomies performed for NSCLC, the causes of postoperative morbidity were multifactorial, however, multivariate analysis did not show any significant factor affecting the mortality, related to this procedure.