Yazar "Hasirci V." seçeneğine göre listele
Listeleniyor 1 - 3 / 3
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Construction of a bioraactor for the degradation of the pesticide, aldicarb(1997) Kök F.N.; Arica M.Y.; Hasirci V.Water soluble derivatives of cellulose are widely used in various biomedical and biotechnological applications. Sodium carboxymethyl cellulose (25 ml, 1-4% w/v) was insolubilized in the form of microspheres using aluminum chloride (150 ml, 0.2-2.0 M) as the crosslinking agent. Microspheres were activated by epichlorohydrin. Methylophilus, a Gram negative bacteria capable of degrading aldicarb, a carbamate pesticide, was immobilized Methylophilus was determined by feeding in aqueous aldicarb solutions (10-400 ppm) at a rate of 20 ml/h. The degradative capability was found to be quite stable for ca. 48 h, and ca. 10% of the aldicarb was degradative capability was found to be quite stable for ca. 48 h, and ca. 10% of the aldicarb was found to be metabolized in the packed bed approach with a single pass application. © 1997 Elsevier B.V. All rights reserved.Öğe Controlled release of Aldicarb from carboxymethylcellulese microcapsules(1997) Arica M.Y.; Yiğtoğlu M.; Lale M.; Kök F.N.; Hasirci V.Sodium carboxymethyl cellulose was converted into microspheres by crosslinking with aluminum chloride. Various microsheres with different amounts of crosslinker, biopolymer of various concentrations and molecular weights, and with different pesticide (Aldicarb) contents and pesticide to polymer ratios were prepared. The pesticide encapsulation efficiencies and aldicarb release kinetics of the resultant microcapsules were investigated. It was possible to modify the release behaviour by varying the above parameters and to have drug release with half-lives longer than 100 hours in aqueous media. The release kinetics were described by first order and zero order kinetics.Öğe Low-molecular-weight heparin-conjugated liposomes with improved stability and hemocompatibility(Taylor and Francis Inc., 1998) Köse G.T.; Arica M.Y.; Hasirci V.Multilamellar vesicles (MLV) containing phosphatidyl choline (PC), cholestrol (CHOL), and stearylamine (SA) in the molar ratio of 7:2:0.2 were prepared by the thin film hydration method. Low-molecular-weight heparin (LMWH, MW: 3000) was conjugated with the MLV using carbodiimide (EDC). Infrared, Raman, and nuclear magnetic resonance spectra and DSC of each sample (MLV, LMWH, and MLV-LMWH) were obtained, enabling the authors to determine the chemical changes that occurred in the MLV structure at the end of the conjugation step. In addition, the changes in the chemical structures of the conjugated samples were revealed by the use of elemental analysis. Particle size analysis was used to determine the difference between the sizes of MLV and MLV-LMWH. In order to study the effect of LMWH on the behavior of MLV-LMWH in blood, osmotic fragility (in saline and plasma), hemolytic activity, and plasma recalcification time tests were carried out. These tests showed that it was possible to construct liposomes that would not induce reactions in the blood and would have potentially longer half-lives in the circulation.