Yazar "Hosseinian, Pezhman" seçeneğine göre listele

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    Bi-layered constructs of poly(glycerol-sebacate)-beta-tricalcium phosphate for bone-soft tissue interface applications
    (Elsevier Science Bv, 2017) Tevlek, Atakan; Hosseinian, Pezhman; Ogutcu, Cansel; Turk, Mustafa; Aydin, Halil Murat
    This study aims to establish a facile protocol for the preparation of a bi-layered poly(glycerol-sebacate) (PGS)/beta-tricalcium phosphate (beta-TCP) construct and to investigate its potential for bone-soft tissue engineering applications. The layered structure was prepared by distributing the ceramic particles within a prepolymer synthesized in a microwave reactor followed by a cross-linking of the final construct in vacuum (<10 mbar). The vacuum stage led to the separation of cross-linked elastomer (top) and ceramic (bottom) phases. Results showed that addition of beta-TCP particles to the elastomer matrix after the polymerization led to an increase in compression strength (up to 14 +/- 2.3 MPa). Tensile strength (sigma), Young's modulus (E), and elongation at break (%) values were calculated as 0.29 +/- 0.03 MPa and 0.21 +/- 0.03; 038 +/- 0.02 and 1.95 +/- 0.4; and 240 +/- 50% and 24 +/- 2% for PGS and PGS/beta-TCP bi-layered constructs, respectively. Morphology was characterized by using Scanning Electron Microscopy (SEM) and micro-computed tomography (mu-CT). Tomography data revealed an open porosity of 35% for the construct, mostly contributed from the ceramic phase since the elastomer side has no pore. Homogeneous beta-TCP distribution within the elastomeric structure was observed. Cell culture studies confirmed biocompatibility with poor elastomer-side and good bone-side cell attachment. In a further study to investigate the osteogenic properties, the construct were loaded with BMP-2 and/or TGF-beta 1. The PGS/beta-TCP bi-layered constructs with improved mechanical and biological properties have the potential to be used in bone-soft tissue interface applications where soft tissue penetration is a problem. (C) 2016 Elsevier B.V. All rights reserved.
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    Polyurethane-Ceramic matrices as orbital implants
    (Taylor & Francis As, 2018) Sahan, Semih; Hosseinian, Pezhman; Ozdil, Deniz; Turk, Mustafa; Aydin, Halil Murat
    Orbital implants are used in such procedures as a method by which the natural void created by the removal of an eye can be filled to restore structural and mechanical stability in the region. Highly biocompatible, easy-to-process, relatively inexpensive, chemically and structurally nonabrasive material with high functionality is yet to be proposed for this application. This study investigates a new semibiodegradable, porous polyurethane/beta-tricalcium phosphate composite as a potential material for orbital implant construction. The orbital implant material presented is composed of polyurethane and ceramic components. Isocyanate, caprolactone monomers, catalyst, and deionized water were used for the preparation of polyurethane. The porosity is observed 96.93% with a 267 +/- 25 mu m average pore size. Young's Modulus was around 50MPa. Composite implants showed no cytotoxic, apoptotic, and necrotic effects. This matrix, with a biocompatible, porous, and light-weight structure, and with both suitability for tissue infiltration and incorporation potential, holds great promise. [GRAPHICS] .
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    Polyurethane/Tricalcium Phosphate Bone Adhesives and Substitutes for Load Bearing Applications
    (Amer Scientific Publishers, 2017) Sahan, Semih; Hosseinian, Pezhman; Ozdil, Deniz; Turk, Mustafa; Aydin, Halil Murat
    The large mechanical forces throughout the sternum and upon the tibia, impact healing capacities following sternotomies and upper tibia osteotomies, respectively. In these fields, there remains a need for materials with a strong adhesive capacity, high mechanical strength when set(1,2) and sufficient porosity to allow osteointegration. The present work investigates castor oil-based polyurethanes synthesized and combined with beta-tricalcium phosphate (beta-TCP) granules for use as bone graft substitutes or adhesives in load-bearing regions. The material is produced via a reaction involving castor oil, caprolactone monomers, an aliphatic diamine-based catalyst and water, with the CO2 gas product creating pores throughout the structure. beta-TCP particles 1000-2000 mu m in diameter that were added to the mixture compose the ceramic phase of the material. Setting completely after 24 hours, the adhesive cubic bone grafts exhibited a 97% structural porosity, Young's Modulus of around 44 MPa, biocompatibility, cell attachment and tissue ingrowth and no apoptotic or necrotic effects. With a fully interconnected porous structure and adhesive qualities, this adhesive bone graft material holds potential for the reconstruction of challenging regions such as the sternum, upper tibia and mandible. Furthermore, the bone grafts can be offered as pre-formed, off-the-shelf products.