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Öğe Open Radial Artery Study(Excerpta Medica Inc-Elsevier Science Inc, 2024) Inanc, Ibrahim H.; Mutlu, Deniz; Efe, Zeynep N.; Kulaksizoglu, Sibel; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, IsmailRadial artery occlusion (RAO) has been the most common postprocedural complication of transradial artery access. The optimal method of prevention of RAO is still lacking. In our study, we aimed to evaluate the effect of patent hemostasis on early (24 hours) and late (2 weeks) RAO prevention. The Open Radial Artery Study was a single-arm, prospective, and multicenter study. The primary end points were early and late RAO at the vascular access site after transradial coronary procedures. Secondary end points were access site hematoma, pseudoaneurysm formation, arteriovenous fistula, and nerve injury. A total of 2,181 patients were analyzed (67% male, mean age 68 years). The mean interventional duration and hemostatic times were 75.6 +/- 55.6 and 60 +/- 5.6 minutes, respectively. Radial artery spasm occurred in 10% of patients (n = 218). Catheter kinking, radial artery rup-ture, or dissection were not observed during the procedure. RAO, hematoma, pseudoa-neurysm, arteriovenous fistula, or nerve damage was not observed in any of the patients in the early or late period. In patients who undergo coronary diagnostic or interventional procedures through transradial artery access, the patent hemostasis method seems a criti-cal step in the prevention of early and late RAO. (c) 2023 Elsevier Inc. All rights reserved. (Am J Cardiol 2024;211:130-136)Öğe Predictors of Acute Stent Thrombosis and High SYNTAX Score in Acute Coronary Syndrome(Sage Publications Inc, 2023) Akboga, Mehmet Kadri; Inanc, Ibrahim H.; Sabanoglu, Cengiz; Akdi, Ahmet; Yakut, Idris; Yuksekkaya, Baran; Nurkoc, Serdar[Abstract No tAvailable]Öğe Review of intravascular lithotripsy for treating coronary, peripheral artery, and valve calcifications(Wiley, 2024) Gruslova, Aleksandra B.; Inanc, Ibrahim H.; Cilingiroglu, Mehmet; Katta, Nitesh; Milner, Thomas E.; Feldman, Marc D.Management of intracoronary calcium (ICC) continues to be a challenge for interventional cardiologists. There have been significant advances in calcium treatment devices. However, there still exists a knowledge gap regarding which devices to choose for the treatment of ICC. The purpose of this manuscript is to review the principles of intravascular lithotripsy (IVL) and clinical data. The technique of IVL will then be compared to alternative calcium treatment devices. Clinical data will be reviewed concerning the treatment of coronary, peripheral artery and valvular calcifications. Controversies to be discussed include how to incorporate IVL into your practice, what is the best approach for treating calcium subtypes, how to approach under-expanded stents, what is the ideal technique for performing IVL, how safe is IVL, whether imaging adds value when performing IVL, and how IVL fits into a treatment program for peripheral arteries and calcified valves.Öğe Systemic Immune-Inflammation Index as a Predictor of Asymptomatic Organ Damage in Patients with Newly Diagnosed Treatment-Naive Hypertension(Inst Nacional Nutricion, 2022) Inanc, Ibrahim H.; Sabanoglu, CengizBackground: Low-grade inflammation is known to facilitate the development of hypertensive organ damage. The systemic immune-inflammation index (SII) is a new inflammatory index based on circulating immune-inflammatory cells. Objectives: The objectives of this study were to investigate the relationship between the SII and asymptomatic organ damage (AOD) in patients with newly diagnosed treatment-naive hypertension (HTN). Methods: A total of 500 participants (>= 18 years) were enrolled in the study, including 250 patients and 250 healthy volunteers. Microalbuminuria of > 30 mg/day or proteinuria of > 150 mg/day, left ventricular mass index of > 95 g/m(2) in women and > 115 g/m(2) in men, and carotid intima-media thickness of > 0.9 mm or the presence of plaque in the carotid were evaluated as AOD indicators. AOD grade was classified as follows: Grade I - One organ involved, Grade II - Two organs involved, Grade III - Three organs involved, and Grade IV - Four organs involved. Results: SII values were higher among patients with HTN than in the control group. Positive correlations were found between the SII and AOD indicators and C-reactive protein levels. Increasing SII values were a common independent predictor of the presence and severity of AOD. The gradually increasing threshold values of the SII from no AOD to Grade III-IV exhibited high diagnostic performance. Conclusions: High SII values were independent predictors of the presence and severity of AOD in patients with newly diagnosed treatment-naive HTN. Considering the role of inflammation in HTN, the SII, which can be easily evaluated using blood parameters, can be an effective prognostic screening tool. ( REV INVEST CLIN. 2022;74(5):258-67)Öğe Use of SAFARI 2n° as workhorse wire for left-sided structural heart interventions(Elsevier Inc, 2024) Inanc, Ibrahim H.; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Cilingiroglu, MehmetBackground: With the advances in percutaneous treatment technologies, the left atrial appendage occlusion (LAAO) and the transcatheter mitral valve repair using MitraClip (TMVR) are increasingly being performed today. The SAFARI 2n degrees guidewire is primarily used during transcatheter aortic valve implantation (TAVI), our group has also been using it during MitraClip and LAAO procedures. Our clinical study aimed to share our data on the safety and effectiveness for the use of the SAFARI 2n degrees guidewire during MitraClip or LAAO procedures. Methods: This study included a total of 1730 patients (948 patients of MitraClip and 782 of LAAO). It was designed as single arm, retrospective, and multicenter between July 2016 and August 2022. SAFARI 2n degrees guidewire was used exclusively during all the procedures. Results: A total of 1730 patients (male 55.8 %) were included in the study. There was no guidewire-related complications, stroke/transient ischemic attack, bleeding (minor/major/life-threatening), need for cardiac surgery, pneumonia, and vascular dissection/rupture in patients undergoing LAAO. There were 2 device-related pericardial effusions without tamponade. No stroke/transient ischemic attack, bleeding (minor/major/life-threatening), mortality, need for cardiac surgery, pneumonia, guidewire-related complication, pericardial effusion, vascular dissection/rupture, or clip embolization was observed in patients undergoing MitraClip. Conclusions: By taking advantage of its pre-shaped structure, the SAFARI 2n degrees guidewire seems to offer a reliable and safe device delivery for both MitraClip and LAAO procedures as a regular work horse wire. Our results should be confirmed by larger randomized or prospective trials.