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Öğe Comparison of American and European Guidelines for the Management of Patients With Valvular Heart Disease(Elsevier Inc, 2023) Inanc, Ibrahim Halil; Cilingiroglu, Mehmet; Iliescu, Cezar; NInios, Vlasis; Matar, Fadi; Ates, Ismail; Toutouzas, KonstantinosThis review compares the recommendations of the recent 2020 American College of Cardiology (ACC)/American Heart Association (AHA) and 2021 European Society of Cardiology (ESC)/European Association for CardioThoracic Surgery (EACTS) guidelines on the management of patients with valvular heart disease (VHD). ACC/ AHA and ESC/EACTS guidelines are both the updated versions of previous 2017 documents. Both guidelines fundamentally agree on the extended indications of percutaneous valve interventions, the optimal use of imaging modalities other than 2D echocardiography, the importance of a multidisciplinary Heart Team as well as active patient participation in clinical decision making, more widespread use of NOACs and earlier intervention with lower left ventricular dilatation thresholds to decrease long-term mortality. The differences between the guidelines are mainly related to the classification of the severity of valve pathologies and frequency of follow-up, level of recommendations of valve intervention indications in special patient groups such as frail patients and the left ventricular diameter and ejection fraction thresholds for intervention. (c) 2022 Elsevier Inc. All rights reserved.Öğe Current Evidence on Prevention of Atrial Fibrillation: Modifiable Risk Factors and the Effects of Risk Factor Intervention(Lippincott Williams & Wilkins, 2023) Akboga, Mehmet Kadri; Inanc, Ibrahim Halil; Keskin, Muhammed; Sabanoglu, Cengiz; Gorenek, BulentAtrial fibrillation (AF) is one of the most encountered arrhythmias in clinical practice. It is also estimated that the absolute AF burden may increase by greater than 60% by 2050. It is inevitable that AF will become one of the largest epidemics in the world and may pose a major health problem for countries. Although AF rarely causes mortality in the acute period, it causes a significant increase in mortality and morbidity, including a fivefold increase in the risk of stroke, a twofold increase in dementia, and a twofold increase in myocardial infarction in the chronic period. Despite all the advances in the treatment of AF, it is better understood day by day that preventing AF may play a key role in reducing AF and its related complications. Modification of the main modifiable factors such as quitting smoking, abstaining from alcohol, changing eating habits, and exercise seems to be the first step in preventing AF. The strict adherence to the treatment process of secondary causes predisposing to AF such as DM, hypertension, obesity, and sleep apnea is another step in the prevention of AF. Both an individual approach and global public health campaigns can be highly beneficial to reduce the risk of AF. In this review, we aimed to summarize the current evidence on the relationship between modifiable risk factors and AF, and the impact of possible interventions on these factors in preventing or reducing the AF burden in the light of recently published guidelines and studies.Öğe Effectiveness and Safety of Same-Day Discharge After Left Atrial Appendage Closure Using Moderate Conscious Sedation: One-Year Follow-Up Outcomes(Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc; Cilingiroglu, Mehmet[Abstract No tAvailable]Öğe EMCAPT Study: Effect of MitraClip Treatment on the Mitral Annulus and Left Atrial Appendage by Transesophageal Echocardiography(Elsevier Science Inc, 2023) Ates, Ismail; Inanc, Ibrahim Halil; Mutlu, Deniz; Polat, Fuat; Kaya, Zeynettin; Arslan, Gamze Yeter; Dogru, Mehmet[Abstract No tAvailable]Öğe EMCAPT study: the effect of MitraClip treatment on the mitral annulus and left atrial appendage evaluation by transoesophageal echocardiography(Termedia Publishing House Ltd, 2023) Polat, Fuat; Inanc, Ibrahim Halil; Dogru, Mehmet; Kadri, Zeina; Dindar, Ismet; Ates, IsmailIntroduction: Data on the change in mitral valve annulus diameter (MAD), and left atrial appendage (LAA) structure and function after transcatheter edge-to-edge repair (TEER) of the mitral valve in patients with secondary mitral regurgitation (MR) are lacking.Aim: To evaluate the change in these parameters just after the clip insertion and its relationship with prognosis in the long term.Material and methods: A total of 50 patients (age: 71.5 +/- 11.3 years, 70% male) with moderate-to-severe or severe MR were included in the study. Transthoracic (TTE) and transoesophageal echocardiography (TEE) were performed before and after the pro-cedure. Prognostic data were recorded with post-procedure telephone calls and follow-up visits.Results: TEE performed during the procedure showed that LAA contraction and filling velocity significantly increased (p < 0.001 for all). Systolic pulmonary artery pressure (SPAP), MAD, and LAA landing zone dimension significantly decreased (p < 0.001 for all). There was only a significant correlation between the MAD before clip placement and the MAD change after clip placement (r = 0.6, p < 0.001). During a mean follow-up period of 10.5 +/- 8.9 months, no significant correlation was found between MAD change, LAA contraction and filling velocity change, and LAA landing zone dimension change and rehospitalization, stroke, mortality, and composite outcome.Conclusions: The contraction and filling velocity of LAA, SPAP, MAD, and LAA landing zone dimension changed significantly im-mediately after the MitraClip procedure. Although these parameters are not related to composite outcome in our study, MAD, LAA diameter, and velocity need to be compared between successful and unsuccessful procedures to predict their clinical relevance.Öğe Feasibility of Same-Day Discharge Approach After Transcatheter Mitral Valve Repair Procedures: One-Year Follow-Up Outcomes(Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc; Cilingiroglu, Mehmet[Abstract No tAvailable]Öğe Hyperlipidemia in Patients with Calcific Tendinitis(Aves, 2022) Polat, Esra; Ozyer, Fatih; Yuce, Elif Ilkay; Inanc, Ibrahim HalilObjective: Calcific tendinitis is a disease of unclear etiology and is associated with metabolic diseases. Hyperlipidemia, one of the metabolic diseases with systemic effects, may be associated with tendinopathy and tendinitis. In this study, we aimed to evaluate the relationship between hyperlipidemia and hypertriglyceridemia, calcific tendinitis, the location of tendinitis, and the frequency of severely symptomatic tendinitis attacks. Methods: This retrospective study included a total of 2055 patients diagnosed with calcific tendinitis between August 1, 2019, and August 1, 2021. The patients were evaluated in terms of their hyperlipidemia and hypertriglyceridemia status, statin and/or fibrate use, and the frequency of tendinitis, and the location of attack. Results: It was observed that 64.4% (n = 230) of the patients had hyperlipidemia and 11.8% (n = 42) had hypertriglyceridemia. It was determined that the most common tendinitis area among 357 patients was the shoulder. There was no statistically significant difference between the frequency of attacks (P = .712), and the location of attack (P = .069) in patients with hyperlipidemia. There was no statistically significant difference between the frequency of attacks (P = .735) and the location of attack (P = .286) in patients with hypertriglyceridemia. However, a statistically significant difference was found between the attack area (P = .032) in patients with triglyceride values higher than the target recommended values. Conclusion: The frequency of hyperlipidemia is high in patients with calcific tendinitis; it will be useful to evaluate patients with calcific tendinitis in terms of hyperlipidemia.Öğe Open Radial Artery (ORAS) Study(Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc; Cilingiroglu, Mehmet[Abstract No tAvailable]Öğe Plasma Leukocyte Cell-Derived Chemotaxin 2 for the Severity of Coronary Artery Disease(Sage Publications Inc, 2022) Akboga, Mehmet Kadri; Inanc, Ibrahim Halil[Abstract No tAvailable]Öğe Superficial Femoral Artery Endovascular Therapy: 12-Month Primary Patency Rates of Contemporary Endovascular Devices from 25,051 Patients(H M P Communications, 2022) Marmagkiolis, Konstantinos; Kilic, Ismail Dogu; Inanc, Ibrahim Halil; Iliescu, Cezar; Ajmal, Muhammad; Cilingiroglu, MehmetBackground. Approximately 5.8 million people experience peripheral arterial disease (PAD) in the United States today. Superficial femoral artery (SFA) disease is the most common cause of symptomatic PAD. New-generation nitinol stents, drug-coated stents, drug-coated balloons (DCB), covered stents, and directional or orbital atherectomy devices have shown promising results. However, clinical equipoise persists regarding the optimal selection of devices, largely attributable to the different inclusion criteria, study populations, length of lesions treated, definitions of patency and restenosis, and follow-up methods in the up-to-date pivotal trials. Methods. A prospective protocol was developed. We performed a literature search using PubMed from January 2011 to July 2021. All published articles including endovascular interventions in the SFA with reported 12-month primary patency rates as endpoints were included. Results. We identified 25,051 patients in 124 studies reporting 12-month primary patency rates in patients with SFA disease. Primary patency rates were (weighted average) 82.6% for drug-eluting stents, 77.2% for drug-coated balloons, 75.2% for covered stents, 73.9% for nitinol self-expanding stents, 66.1% for atherectomy, and 44.5% for bare balloon angioplasty. Conclusion. The most frequently used endovascular devices yielded various 12-month primary patency rates ranging from 44.5% to 82.6%. The increased variation in inclusion criteria, lesion length, and complexity of lesions between studies does not allow direct comparison between the individual devices. Larger randomized trials in specific patient populations comparing these modalities are needed well before we can make proper recommendations on the superiority of one device over the other.Öğe Systemic Immune-Inflammation Index and C-Reactive Protein/Albumin Ratio Could Predict Acute Stent Thrombosis and High SYNTAX Score in Acute Coronary Syndrome(Sage Publications Inc, 2023) Akboga, Mehmet Kadri; Inanc, Ibrahim Halil; Sabanoglu, Cengiz; Akdi, Ahmet; Yakut, Idris; Yuksekkaya, Baran; Nurkoc, SerdarAcute stent thrombosis (AST) is associated with increased morbidity and mortality. The main aim of this study was to evaluate the prognostic value of the systemic immune-inflammation index (SII) and C-reactive protein (CRP) to albumin ratio (CAR) in predicting AST and high SYNTAX score in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). The criteria of the Academic Research Consortium were used to determine definite stent thrombosis. A total of 2077 consecutive patients with ACS undergoing PCI were retrospectively enrolled. Platelet, white blood cell and neutrophil counts, as well as SII, CRP, CAR, and peak cardiac troponin I (cTnI) values were significantly higher, whereas the lymphocyte count and albumin values were significantly lower in the AST (+) group compared with the AST (-) group (P < .05). SYNTAX score showed significant positive correlations with SII (r = .429, P < .001) and CRP (r = .402, P < .001). Multivariate logistic regression analysis showed that SII and CAR, as well as age, diabetes mellitus, stent length, and peak cTnI are independent predictors of AST and high SYNTAX score. In conclusion, the SII and CAR are simple, relatively cheap, and reliable inflammatory biomarkers that can predict AST and high SYNTAX scores in ACS.Öğe Transcatheter mitral valve repair in a liver transplant candidate(Wiley, 2022) Ates, Ismail; Mutlu, Deniz; Inanc, Ibrahim Halil; Marmagkiolis, Konstantinos; Iliescu, Cezar A.; Kilic, Ismail Dogu; Cilingiroglu, MehmetUntreated severe mitral regurgitation (MR) is associated with poor outcomes due to the adverse consequences of long-standing volume overload on the left ventricle and left atrium, which leads to pulmonary hypertension and right-sided heart failure. Early intervention results in favorable long-term outcomes making appropriate timing of intervention very critical. We present a 53-year-old male with severe symptomatic MR and right sided-heart failure which progressed to cardiac cirrhosis necessitating enrollment to the liver transplant list. Transcatheter mitral valve repair (TMVR) using MitraClip implantation resulted in impressive clinical improvement and resolution of cirrhosis. Eventually, the patient was taken off the transplant list. Treatment of severe MR may lead to improvements in congestive hepatopathy.Öğe Use of IVOCT for Assessment of the Lesion Characteristics as Well as Evaluation of Vascular Healing Effects of Different Technologies in PAD Patients(Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc; Cilingiroglu, Mehmet[Abstract No tAvailable]Öğe Use of SAFARI 2 as Workhorse Wire for Left-Sided Structural Heart Interventions(Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Rollefson, William; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc[Abstract No tAvailable]
