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Öğe The Antibody Response to Helicobacter pylori in the Sera from a Rural Population in the Central Anatolia Region of Turkey(Pharmaceutical Soc Japan, 2008) Apan, Teoman Zafer; Iseri, Latife; Aksoy, Altan; Güliter, SefaHelicobacter pylori (H. pylori) infection is common worldwide. Although the seropositivity of H. pylori rates has been unclear in the Turkish population. In this study, anti-H. pylori IgG seroprevalence and anti-cytotoxin-associated gene A (CagA) IgG positivity were evaluated. The sera of 880 people without gastrointestinal symptoms (384 males, 496 females) were tested for anti-H. pylori IgG and anti-CagA IgG antibodies by enzyme linked immunoassay method. Anti-H. pylori IgG antibodies were positive in 263 sera (41%) and their rates increased with age. The seroprevalence of anti-H. pylori IgG was higher in females (43.8%) than in males (38%). Of the anti-H. pylori IgG positive sera, 194 (53%) were also positive for anti-CagA IgG. The anti-CagA IgG positivity did not significantly differ with age. However, the lowest rate (46.6%) was determined among individuals 2029 years of age and the highest rate (62.5%) among individuals over 60 years age. Anti-CagA IgG positivity rates were higher in males (87.5%) than in females (37.5%).Öğe Changes in the rates of antimicrobial resistance among clinical isolates of Pseudomonas aeruginosa between 2002 and 2004 in a tertiary-care teaching hospital in Turkey(Edizioni Int Srl, 2008) Iseri, Latife; Bayraktar, Mehmet RefikPseudomonas aeruginosa is an important opportunistic pathogen usually resistant to most antimicrobials. We present changes in the resistance pattern of R aeruginosa to amikacin (AK) and ciprofloxacin (CIP) between January 2002 and June 2004. The physicians of each unit were given information on antibiotic resistance rates of P aeruginosa isolated from ward patients at regular intervals. The antibiotic resistance of 161 P aeruginosa isolates isolated from intensive care units (ICUs) and non-ICUs were tested by disk diffusion method, and the results were interpreted according to the guidelines of National Committee for Clinical Laboratory Standards. Thirty-five percent of all the P aeruginosa isolates were resistant to AK in 2002, 18% in 2003, and 20% in 2004. The CIP resistance rates were 4% in 2002, 26% in 2003 and 20% in 2004. In that period, resistance to AK decreased, whereas resistance to CIP increased. The usage rate of AK in 2002 was 32%, which fell to 26% in 2003 (p<0.05). This rate increased to 27% in 2004 (p<0.05). The usage rate of CIP was very low in 2002 (3%). Subsequently, it increased to 8% in 2003 and 2004 (p<0.05). The changes in resistance rates may have been due to alteration in drug usage policy in our hospital. It is important to provide physicians with information on antibiotic resistance rates at regular intervals to guide therapy for critical P. aeruginosa infections.Öğe Is it Subungual Melanoma? Fungal Melanonychia due to Phoma Glomerata(Cukurova Univ, Fac Medicine, 2015) Sari, Elif; Iseri, Latife; Kocak, Mukadder; Yildiz, DilaraA 32-years-old female patient referred to our clinic with melanotic color change at her right thumb nail. It was suspected from subungual melanoma. Therefore a full thickness biopsy and an excavation example was taken from the nail for the histologic and microbiologic examination. The lesion was reported as fungal melanonychia which was occured by Phoma Glomerata. As far as we know this is the first case that occured by Phoma Glomerata. Also the case could be misdiagnosed as subungual melanoma. Therefore we aimed to share this case with our colleagues.Öğe Minimum inhibitory concentration values and problematic disk break points of tigecycline against vancomycin and/or high-level aminoglycoside-resistant enterococci(Elsevier Sci Ltd, 2016) Iseri, Latife; Sahin, Esra; Dolapci, Istar; Yuruken, ZehraBackground: Tigecycline is a new, semisynthetic glycylcycline. It is active against important multidrug resistant pathogens. Aim: The purpose of this study was to investigate the sensitivity of multidrug-resistant enterococci to tigecycline, and to test the correlation between the minimal inhibitory concentration (MIC) and disk diffusion methods. Materials and methods: The antimicrobial sensitivity of 108 multidrug-resistant isolates, which included 52 vancomycin-resistant enterococci (VRE) and 56 high-level aminoglycoside-resistant (HLAR) enterococci, was tested by the E test, broth microdilution test and disk diffusion methods. Results: All of the isolates were sensitive to tigecycline, as determined by the E test and broth microdilution test. The MIC 90 value (0.19 mu g/mL) of tigecycline for HLAR enterococci was higher than that for VRE (0.094 mu g/mL). When results were evaluated according to species, the MIC values of tigecycline for Enterococcus faecalis were higher than those for the other species. Eleven (10.1%) isolates produced false resistance results (zone diameter 615 mm) by the disk diffusion method. These cases were classified as major errors. Eight (7.4%) isolates had intermediate sensitivity (sensitivity zone of 16 or 17 mm), which were classified as minor errors. The major and minor error percentages of HLAR enterococci (14.2% major, 10.7% minor error) were higher than those of VRE (5.7% major, 3.8% minor error). These results indicate that tigecycline is effective against multidrug-resistant enterococci. The sensitivity of multidrug-resistant enterococci to tigecycline should be investigated by MIC methods. The disk diffusion method causes major errors, especially for HLAR enterococci. (C) 2015 The Authors. Alexandria University Faculty of Medicine. Production and hosting by Elsevier B.V.Öğe The Prevalence of Enterotoxigenic E. Coli Isolated from the Stools of Children Aged 0-10 Years with Diarrhea in Mid-Anatolia Region, Turkey(Springer, 2011) Iseri, Latife; Apan, Teoman Zafer; Aksoy, Altan; Koc, Figen; Gocmen, Julide Sedef; Nuristani, DibaThe stool samples from 245 patients with diarrhea were tested for heat labile toxin (LT) and heat stable toxins (ST) by passive latex agglutination and enzyme immunoassay methods respectively. Twelve (4.9%) enterotoxigenic E. Coli ETEC strains were isolated. Five strains (2%) expressed ST, and 7 (2.8%) expressed LT.
