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Öğe Concurrent peste des petits ruminants virus and pestivirus infection in stillborn twin lambs(Amer Coll Vet Pathologist, 2008) Kul, O.; Kabakci, N.; Ozkul, A.; Kalender, H.; Atmaca, H. T.Concurrent infection with peste des petits ruminants virus (PPRV) and pestivirus was diagnosed in stillborn twin lambs. With the flock history, the findings of epidermal syncytial cells and necrotizing bronchitis/bronchiolitis prompted testing for PPRV infection, and PPRV antigen was detected by immunohistochemistry (IHC) in the skin, lungs, kidneys, rumen, and thymus. Macroscopic anomalies that were typical of border disease included scoliosis, brachygnathism, prognathism, arthrogryposis, hydranencephaly, cerebellar hypoplasia, and hairy fleece; pestiviral antigen was detected by IHC in the brain, liver, lungs, and kidneys. Tissues from both lambs were positive by reverse transcriptase-polymerase chain reaction (RT-PCR) for PPRV and pestivirus. To the authors' knowledge, PPR has not been reported previously as a congenital infection or in combination with pestiviral infection.Öğe Distribution of 3β-Hydroxysteroid Dehydrogenase in the Cerebellum in Canine Distemper Virus Infection(Academic Press Ltd Elsevier Science Ltd, 2002) Yarim, M.; Kabakci, N.The cerebella of eight dogs naturally infected with canine distemper virus (CDV) and two normal dogs were examined immunohistochemically for glial fibrillary acidic protein (GFAP) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD). The clinical diagnosis of canine distemper was Confirmed histopathologically and by the immunohistochemical demonstration of CDV antigen. In all dogs (healthy and infected), the Purkinje cells of the cerebellum were immunolabelled for 3beta-HSD activity. In infected dogs, 3beta-HSD labelling was prominent in astrocytes (particularly in areas of astrocytosis) whereas in healthy dogs such immunolabelling was weak. Double immunolabelling demonstrated that all GFAP-positive cells (especially in demyelinating areas) were also positive for 3beta-HSD. The results suggest that 3beta-HSD expression by astrocytes is associated with demyelination in CDV infection. (C) 2002 Elsevier Science Ltd. All rights reserved.Öğe Pathological, clinical and biochemical investigation of naturally occuring pregnancy toxemia of sheep(Veterinary Faculty, 2003) Kabakci, N.; Yarim, G.; Yarim, M.; Duru, O.; Yagci, B.B.; Kisa, U.A sick ewe in late pregnancy presented with clinical incoordination, lipping, amaurosis, head tilt gait and nervous symptoms such as circling movements. A smell of ketones on the breath was detected. The sick animal died during clinical examination and, together with three more dead animals belonging to the same flock, was submitted to the laboratory for necropsy. The uteri of all pregnant animals contained late-term twin fetuses. The most prominent lesion was extensive fatty infiltration of the liver Massive lipidosis and lipid vacuoles were seen in sections of the livers. In three brains, there was prominent vacuolation in the white matter Urine analysis revealed ketonuria in most of the suspected sheep from the same flock. Serum glucose, cholesterol, high density lipoprotein cholesterol, and blood urea nitrogen concentrations were lower (pless than or equal to0.05) and serum triglycerides, aspartate aminotransferase and alanine aminotransferase activities were higher (pless than or equal to0.05) in these sheep than in the controls. After a change of diet and treatment, with glucose and dexamethasone serum glucose levels significantly increased (pless than or equal to0.001) and urine ketone bodies decreased but the other biocemical differences remained.Öğe The prevalence, colonization sites and pathological effects of gastric helicobacters in dogs(Scientific Technical Research Council Turkey, 2002) Diker, K.S.; Haziroglu, R.; Akan, M.; Çelik, S.; Kabakci, N.The prevalence and colonization sites of Helicobacter slap. in the stomachs of dogs, and their association with gastric pathology were investigated. Scraping cytology, culture, urease test and histology were used to detect helicobacters in the stomachs of necropsied dogs. Gastric Helicobacter spp. were detected in 103 (84.4%) of 122 dogs from I month to 14 years of age. The uncultured spiral organisms seen in the most of stomachs were designated as H. heilmannii. Microscopical examination of stained mucosal scrapings was found to be superior for the diagnosis of gastric helicobacters. Six (4.9%) spiral organisms were isolated from 122 stomachs and all were identified as H. felis. Helicobacter spp. were detected in the fundus, corpus and antrum of 103, 101 and 53 dogs, respectively. Organisms were denser in the fundus and corpus than in the antrum, Histological changes comparable to mild chronic gastritis or chronic active gastritis were found in 56.3% of Helicobacter positive dogs and 47.4% of Helicobacter-negative dogs. H. felis was found only in dogs with chronic active gastritis.
