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Öğe Adverse effect of VEGFR-2 (rs1870377) polymorphism on the clinical course of COVID-19 in females and males in an age-dependent manner(Elsevier, 2023) Kocakap, Derya Beyza Sayin; Kaygusuz, Sedat; Aksoy, Emel; Şahin, Ömer; Baccioglu, Ayse; Ekici, Aydanur; Kalpaklioglu, Ayse FusunThe COVID-19 pandemic has affected people worldwide with varying clinical presentations ranging from mild to severe or fatal, and studies have found that age, gender, and some comorbidities can influence the severity of the disease. It would be valuable to have genetic markers that might help predict the likely outcome of infection. For this objective, genes encoding VEGFR-2 (rs1870377), CCR5D32 (rs333), and TLR3 (rs5743313) were analyzed for polymorphisms in the peripheral blood of 160 COVID-19 patients before COVID-19 vaccine was available in Turkiye. We observed that possession of the VEGFR-2 rs1870377 mutant allele increased the risk of severe/moderate disease in females and subjects >= 65 years of age, but was protective in males <65 years of age. Other significant results were that the CCR5D32 allele was protective against severe disease in subjects >= 65 years of age, while TLR3 rs5743313 polymorphism was found to be protective against severe/moderate illness in males <65 years of age. The VEGFR-2 rs1870377 mutant allele was a risk factor for severe/moderate disease, particularly in females over the age of 65. These findings suggest that genetic polymorphisms have an age-and sex-dependent influence on the severity of COVID-19, and the VEGFR-2 rs1870377 mutant allele could be a potential predictor of disease severity.(c) 2023 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.Öğe Allergic Contact Dermatitis due to Medical Mask; A Case Report(BILIMSEL TIP YAYINEVI, 2020) Alpagat, Gulistan; Dumanoglu, Betul; Poyraz, Merve; Alan Yalim, Sumeyra; Baccioglu, Ayse; Kalpaklioglu, Ayse FusunAllergic contact dermatitis occurs as a result of delayed hypersensitivity reaction caused by various exogenous substances. Here, a case of allergic contact dermatitis due to medical mask use is presented. A 39-year-old female patient was admitted to Allergy outpatient clinic with complaints of red and itchy maculopapular lesions, and small blisters on the cheeks, nasolabial folds, chin and neck under the chin that started three days ago. She had no chronic illness, massive sunshine exposure, history of systemic and topical medication intake and cosmetic use. The patient has been using washable masks for the whole COVID-19 pandemic period, however she used medical masks instead of washable ones 15 days ago once and for the last two days before the beginning of her complaints. Even though there was no reaction in her first contact, the above dermatitis lesions restricted to mask area developed 24-48 hrs after starting to use it for the second time. Allergic contact dermatitis was diagnosed due to skin lesions suitable with dermatitis and occurrence of the reaction after the second contact to a suspicious substance. She was recommended to stop using medical masks, and a treatment of oral antihistamine and topical steroid was prescribed. After her complaints resolved completely, a challenge with a different brand of medical mask was performed, and no reaction was observed. As a result, this case implicates that allergic contact dermatitis may occur due to using medical masks, and it is important to use masks with standardized approval since they are essential in preventing airborne infections including corona virus.Öğe Comparison of acute phase reactant pentraksin-3 and inflammatory parameters in acute and stable pulmonary embolism(European Respiratory Soc Journals Ltd, 2021) Cimen, Asiye Busra; Kalpaklioglu, Ayse Fusun[Abstract No tAvailable]Öğe Comparison of azelastine versus triamcinolone nasal spray in allergic and nonallergic rhinitis(Sage Publications Inc, 2010) Kalpaklioglu, Ayse Fusun; Kavut, Ayse BacciogluBackground: Intranasal antihistamine has not been thoroughly studied in the treatment of rhinitis of different etiologies. This study was designed to show the comparative efficacy of nasal antihistamine and nasal corticosteroid in patients with allergic rhinitis (AR) and nonallergic rhinitis (NAR). Methods: A comparison of the efficacy of azelastine nasal spray (AZENS) versus triamcinolone acetonide nasal spray (TANS) on total nasal symptom scores (TNSS), nasal peak inspiratory flow rate (nPIFR), and nasal cytology was studied in a 2-week randomized parallel-group trial. The Epworth Sleepiness Scale (ESS) and health-related quality of life (HRQoL) were also analyzed. Results: The study group consisted of 132 patients (100 women and 32 men) with a mean age of 33.14 +/- 12.52 years, Sixty-nine patients had AR and 63 had NAR. Although TNSS including sneezing, itching, rhinorrhea, congestion-but not anosmia-significantly improved in both groups, intranasal azelastine reduced ocular symptoms greatly compared with intranasal triamcinolone (p = 0.05). Patients with NAR seemed to respond more to TANS, whereas AZENS was more useful in AR. The nPIFR improved in AR and NAR, with no significant difference between the treatment groups. Neither intranasal azelastine nor intranasal triamcinolone changed cytology in nasal lavage. Both medications were well tolerated, but AZENS led to more adverse events than TANS (56.9 and 19%, respectively; p = 0.001), mainly because of bitter taste. Scores on each domain of generic HRQoL (36-Item Short-Form Health Survey) and mini-rhinitis QoL questionnaires, as well as ESS score, significantly improved in both groups, irrespective of rhinitis etiology. Conclusion: In this first comparative demonstration, AZENS appears to be as effective as triamcinolone in symptom scores, nPIFR, ESS, and HRQoL, equally in AR and NAR. (Am J Rhinol Allergy 24, 29-33, 2010; doi: 10.2500/ajra.2010.24.3423)Öğe Desensitization in Interferon-beta 1a Allergy: A Case Report(Karger, 2009) Kalpaklioglu, Ayse Fusun; Kavut, Ayse Baccioglu; Erdemoglu, Ali KemalWe report a 41-year-old patient with multiple sclerosis (MS) who was successfully desensitized after she developed non-injection-site urticaria and angioedema due to interferon (IFN)-beta 1a. Although a few cases of urticaria and anaphylaxis have been reported in the literature, to our knowledge this is the first report of a successful desensitization with IFN-beta 1a. Desensitization with IFN-beta 1a allowed us to continue with the administration of interferon-beta, which is a mainstay in treatment for MS. Copyright (C) 2009 S. Karger AG, BaselÖğe Does Serum Leptin Differ Between Patients With Rhinitis Of Allergic Vs Nonallergic Aetiology?(Mosby-Elsevier, 2014) Kalpaklioglu, Ayse Fusun; Baccioglu, Ayse…Öğe Does serum leptin levels differ between patients with rhinitis of allergic versus nonallergic aetiology?(Wiley, 2021) Kalpaklioglu, Ayse Fusun; Baccioglu, Ayse; Yalim, Sumeyra AlanBackground Leptin may play a critical role in airway inflammation. However, it has rarely been evaluated in rhinitis with different aetiology. This study aimed to compare the serum leptin levels between allergic rhinitis (AR) and nonallergic rhinitis (NAR). Methods Patients with chronic rhinitis were classified due to skin prick (ALK-Abello/Madrid) and/or serum-specific immunoglobulin E tests (UniCAP 100-Pharmacia), against to aeroallergens if concordant with symptoms. Results A total of 398 patients with a mean age of 29.03 years were recruited and grouped as AR and NAR. Mean serum leptin levels were similar in patients with NAR and AR, as well as in patients with and without asthma, but were significantly higher in females than males in both groups. Also, leptin levels were significantly higher in obese than nonobese patients in AR. In correlation analysis, leptin levels were found to be correlated with female gender, older age, and high body mass index (BMI) in the whole group. Despite the higher total nasal symptom score (TNSS) in patients with AR compared with NAR, there was no association of leptin levels with TNSS, severity and seasonality of symptoms, and allergen sensitization. In logistic regression analysis, younger age and high serum leptin levels were found to be independent predictors for the diagnosis of AR. Conclusions We conclude that female patients with high BMI are more prone to AR probably due to immunological effects of adipose tissue, in addition to hormonal factors. This study showed that leptin measurement has limited value as a sole diagnostic tool to differentiate AR and NAR.Öğe Erythema Multiforme-like Dermatitis Due to Isoniazid Hypersensitivity in a Patient With Psoriasis(Quadrant Healthcom Inc, 2021) Baccioglu, Ayse; Karabulut, Ayse Anil; Kalpaklioglu, Ayse Fusun[Abstract No tAvailable]Öğe Hypereosinophilia of undetermined significance in a rheumatoid arthritis patient(Wiley, 2022) Dumanoglu, Betul; Alpagat, Gulistan; Poyraz, Merve; Baccioglu, Ayse; Kalpaklioglu, Ayse Fusun[Abstract No tAvailable]
