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Öğe Controlled Trial of Efficacy of Dexketoprofen in Sciatic Nerve Crush Injury in Rats(Journal Neurological Sciences, 2014) Kaptan, Hulagu; Kasimcan, Omur; Ayaz, Murat; Bozdogan, Onder; Karabagli, HakanObject: Local applications of Dexketoprofen trometamol (dex) have been shown to increase in the sciatic nerve functional tests following the nerve injuries. The aim of the current study was to compare the efficacy of dex application for 1 and 5 days following nerve injury rat model. Possible effects of dex were checked by means of the Sciatic Function Index (SFI), Withdrawal of the Reflex Leg (WRL), number of axons, axon diameter, and nerve diameters. Material Methods: The animal crushed model was done through Aesculap -Yasargil aneurysm method on Wistar albino (N=21) right sciatic nerves. In order to achieve desired purpose 3 experimental groups were organized: Group 1: control (injured and no drug); Group2: dexketoprofen 1 days (injured and single dose of drug); Group3: dexketoprofen 5 days (injured and single dose of 5 times drug applications). Injections were done through the tissue expander's injection port with a connecting tube directed at the crush-injured site. Functional recovery of the sciatic nerves was evaluated with the improvement in the SFI values. Additionally, recovery of sensory function was assessed through WRL results and histopathological examination was performed 6 week following the injury. Results: At the end of the experimental periods there was no significant differences were found between the experimental group of animals on the bases of the number of axons, axon diameter, and nerve diameter. Moreover, up 30th day of the experimental period our functional test results have shown that there was no difference between the groups. But following the induction of the injury, the statistical significances were seen on the functional tests. This effect was seen only if the multi-dose application of the dex. Conclusions: This study suggests that; dexketoprofen trometamol of 5 consecutive days, has revealed positive significant changes in the sciatic nerve injury through analgesic effect of it.Öğe Correlation of low back pain caused by lumbar spinal stenosis and depression in women: a clinical study(Springer, 2012) Kaptan, Hulagu; Yalçın, Esra Süer; Kasımcan, ÖmürLow back pain (LBP) due to spinal stenosis may be one of the most debilitating symptoms to decrease the quality of life. The cause and effect association of LBP and depression is vague. Pain may also be a somatization symptom of depression. This is more frequent in the female population. This clinical study was designed to evaluate the correlation between the level of back pain caused by lumbar spinal stenosis and depression in the female population. The study included 50 consecutive female patients with spinal stenosis. The stenosis diagnosis is made by neurological examination and neuro-imaging. The study group was psychiatrically evaluated and grouped as those with and without depression. Visual analog scale (VAS), Oswestry disability index (ODI) and Hamilton Depression Scale (HDS) were utilized in initial evaluation of the group. Twenty-one patients with lumbar spinal stenosis had depression (DLS Group) and 29 did not (LSS Group). Mean HDS scores were 8.97 and 32.48 for Group LSS and Group DLS, respectively. There was a statistically significant difference between the VAS scores of the groups (the mean VAS scores were 5.6 and 7.6, for groups LSS and DLS, respectively). The mean ODI values for LSS (65.24 +/- A 4.58) and DLS (75.1 +/- A 6.7) groups were also significantly different. In Group DLS, there were positive correlations between ODI and VAS with HDS (p < 0.001). Our findings indicated a relationship between lumbar spinal stenosis associated pain levels and depression. However, the cause and result relationship still needs to be established yet.Öğe Efficacy of Gabapentin for Radiculopathy Caused by Lumbar Spinal Stenosis and Lumbar Disk Hernia(Japan Neurosurgical Soc, 2010) Kasımcan, Ömür; Kaptan, HulaguThe efficacy of gabapentin monotherapy was investigated against both acute or chronic radicular pain caused by lumbar disk hernia (LDH) or lumbar spinal stenosis (LSS). Seventy-eight patients with radicular pain, 10 males and 68 females aged 23 to 76 years (mean 49.4 years), caused by LSS in 45 patients or LDH in 33 patients were treated with oral administration of gabapentin and were followed up for 3 months. The evaluation included neurological examination, Odom's criteria, visual analog pain scale (VAS), and walking distance. Gabapentin treatment resulted in decreased VAS scores in both groups. Odom's criteria scores had improved to excellent or good in 36 patients with LSS and 28 patients with LDH. Furthermore, walking distance was significantly longer at the 3rd month of the treatment protocol. Eight patients discontinued gabapentin therapy because of the side effects. Gabapentin could be an option in the conservative management of acute or chronic radicular pain.Öğe Lumbar Disc Hernia and Erectile Dysfunction(Aves, 2011) Kaptan, Hulagu; Kulaksizoglu, Haluk; Kasimcan, OmurLumbosacral disc disease and sexual dysfunction are two non-lethal health entities that are common and decrease quality of life of patients. With interruption of communication between the brain and the penis, erectile dysfunction should be expected. However, there are very limited data on the interaction of lumbosacral disc disease and sexual functioning. The aim of this review is to highlight the association between lumbosacral disc disease and sexual dysfunction and to overview the diagnosis and treatment options for this subset of patients. (Archives of Neuropsychiatry 2011; 48 Supplement 1:31-4)Öğe Mature Teratoma Arising From The Anterior Fossa In An Adult(Nobel Ilac, 2011) Kaptan, Hulagu; Kasimcan, Omur; Cakiroglu, Kutay; Kilic, CelalGerm cell tumors may be classified as germinomas, which represent approximately two thirds of all intracranial germ cell tumors, and non germinomas, which include embryonal carcinomas, choriocarcinomas and teratomas. Teratoma may be mature(benign) or immature (malignant). Mature teratomas located in the anterior fossa are extremely rare and have benign characters. Nongerminomatous germ cell tumors, especially teratomas and choriocarcinomas, tend to occur in younger children. Mature teratoma in adults is very rare. In this paper we report a twenty-eight years old patient with mature teratoma in anterior fossa and pneumocephaly.Öğe Protective Effects of Methotrexate and Tenoxicam in Peridural Fibrosis in Rat Laminectomy Model(Journal Neurological Sciences, 2015) Kasimcan, Omur; Kaptan, Hulagu; Aktas, Savas; Bakar, Bulent; Karabagli, HakanObjective: Peridural fibrosis after laminectomy is an important surgical problem. Tenoxicam is a nonsteroidal antiinflammatory drug and an oxicam derivative acting by inhibiting the formation of prostaglandin and eicosanoids. Low dose methotrexate which has been used as an antiinflammatory agent rhomatoid arthritis inhibits the synthesis of potentially toxic compounds those accumulate in inflamed tissues. The aim of this study was to evaluate and compare the efficacy of these two independent pharmacological agents in the inhibition of peridural fibrosis. Methods: L3-4-5 bilateral laminectomy with sparing the dura mater integrity was perfomed to 30 male Wistar albino rats. Except the SHAM group, low dose methotraxate (0.2 mg/kg) or tenoxicam (0.5 mg/kg) was administered on the dura mater before the surgical closure. After 42 days, all rats were euthanized and their spinal columns performed laminectomy were removed for the histopathological evaluation. Results: The peridural fibrosis grades of the groups administered low dose methotrexate or tenoxicam were lower than SHAM group grades. They have lower fibroblast counts than SHAM group numerically, although there was no statistically significant difference among groups. Conclusion: Local usage of low dose methotrexate and tenoxicam may be helpful option for prevention of peridural fibrosis after laminectomy procedures in future.
