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    Evaluation of complete blood count parameters, cell ratios, and cell volume indices in mushroom poisonings
    (Sage Publications Ltd, 2019) Dogan, M.; Karahan, I
    Objective: Mushroom poisoning is still a significant health-care problem, with the potential to affect blood parameters. The present study analyses the effect of mushroom poisoning on complete blood cell parameters, cell ratios, and cell volume indices and the effect of the mentioned parameters on prognosis/hospital length of stay. Methods: The study involved the retrospective assessment of 48 patients who became symptomatic after ingesting mushrooms. Patients who were 18 years and above and who spent at least one day in hospital were included in the study. The control group comprised individuals with similar characteristics to the patient group. The complete blood cell parameters, platelet indices (mean platelet volume, plateletcrit (PCT)), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio levels were compared between the two groups, and these ratios were analyzed for any correlation with length of hospital stay. Results: NLR was significantly higher and PCT was significantly lower in the mushroom-poisoned group, while all other parameters were similar between the groups. NLR had a positive correlation and PCT had a negative correlation with length of hospital stay. Conclusion: NLR and PCT levels can provide information about prognosis and can aid in the prediction of hospital stay in mushroom-poisoned patients. Further investigations are needed to investigate effects of intoxication on hematological system elements.
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    A new inflammatory marker in overweight patients: triggering receptor expressed on myeloid cells-1
    (COMENIUS UNIV, 2020) Cifci, A.; Ceylan, Durmaz S.; Oklu, K.; Gungunes, A.; Katar, D.; Karahan, I; Boyunaga, H.
    BACKGROUND: Triggering receptor expressed on myeloid cells 1 (TREM-1) is secreted by phagocytes in adipose tissue and it also upregulates the expression of genes involved in the inflammatory response and atherosclerotic conditions. This study was aimed to investigate the serum TREM-1 levels in overweight patients. METHODS: Twenty-eight subjects in the overweight group (OG) and 20 age-matched healthy subjects in the control group (CG) (BMI 27.6 +/- 1.2 vs 23.1 +/- 2.17 kg/m(2), respectively, p< 0.001) were included in the study. The serum sTREM-1 level was measured by ELISA. The homeostasis model assessment score (HOMA-IR) was also calculated. RESULTS: The mean TREM-1 levels were significantly higher in OG than in CG (407.3 +/- 323.7 vs 150.3 +/- 152.7 pg/mL, respectively, p< 0.001). The HOMA-IR score was also significantly higher in OG than in CG (3.42 +/- 3.63 vs 2.77 +/- 1.61, respectively). A positive correlation was detected between TREM-1 and BMI (r= 0.318, p= 0.028). CONCLUSIONS: This study mainly demonstrated that a high serum TREM-1 level might be an early inflammatory marker in overweight patients. We found that TREM-1 might be associated with BMI in overweight patients regardless of insulin resistance (Tab. 1, Ref. 21). Text in PDF www.elis.sk.