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    Evaluation of minimal erythema dose in patients who use dihydropyridinic calcium channel blockers
    (2018) Demırkan, Serkan; Savk, Ekin; Sendur, Neslihan; Karaman, Goksun; Uslu, Meltem
    Aim: One of the most frequent and reliable methods for determining phototoxicity is to monitor the minimal erythemadose(MED) related to UVA after using the drug.In our study, it was aimed to determine whether dihydropyridine-derived calcium channel blockers cause phototoxicity.Material and Methods: Eight open areas of 1 cm2 were left on the backs of the patients. Eight different doses of UVA wereapplied to these 8 areas starting at 2 j / cm2 and increasing to 16 j / cm2; After 24 hours, the first area which had significanterythema was checked. This value is defined as minimal erythematous dose (MED). MED values of patients were measuredbefore treatment and on the 7th day of treatment.Results: Thirty-nine hypertensive patients, 20 female and 19 male, were included in the study.Conclusion: Dihydropyridine-derived calcium channel blockers did not cause a change in MED for UVA and therefore didnot cause phototoxicity.