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Öğe The analysis of the factors affecting lumbar spinal stenosis in adult patients(Springer London Ltd, 2010) Kaptan, Huluga; İlhan, Mert; Cakıroğlu, Kutay; Kasimcan, Omur; Kılıç, CelalBackground In this study 67 lumbar spinal stenosis in adult patients operated in our clinic in 3 years are aimed to be analysed in terms of clinical and surgical techniques. Methods Diagnoses were made on the basis of patients' histories and their clinical examinations. Results Average age was 52.16 +/- 8.9 (33-64). 70.1% (47) of patients were females and 29.9% (20) were males. The most frequent neurological symptoms were 71.1% lasque (+) and 56.7% sensory loss. The anterior-posterior diameter was below 11.5 mm in 56.7% of the cases. Partial recovery was observed in the early term of 71.6% the cases. 56.7% of the cases were applied total laminectomy. Conclusion Decompressive laminectomy can be performed safely and effectively in patients of with lumbar stenosis.Öğe Controlled Trial of Efficacy of Dexketoprofen in Sciatic Nerve Crush Injury in Rats(Journal Neurological Sciences, 2014) Kaptan, Hulagu; Kasimcan, Omur; Ayaz, Murat; Bozdogan, Onder; Karabagli, HakanObject: Local applications of Dexketoprofen trometamol (dex) have been shown to increase in the sciatic nerve functional tests following the nerve injuries. The aim of the current study was to compare the efficacy of dex application for 1 and 5 days following nerve injury rat model. Possible effects of dex were checked by means of the Sciatic Function Index (SFI), Withdrawal of the Reflex Leg (WRL), number of axons, axon diameter, and nerve diameters. Material Methods: The animal crushed model was done through Aesculap -Yasargil aneurysm method on Wistar albino (N=21) right sciatic nerves. In order to achieve desired purpose 3 experimental groups were organized: Group 1: control (injured and no drug); Group2: dexketoprofen 1 days (injured and single dose of drug); Group3: dexketoprofen 5 days (injured and single dose of 5 times drug applications). Injections were done through the tissue expander's injection port with a connecting tube directed at the crush-injured site. Functional recovery of the sciatic nerves was evaluated with the improvement in the SFI values. Additionally, recovery of sensory function was assessed through WRL results and histopathological examination was performed 6 week following the injury. Results: At the end of the experimental periods there was no significant differences were found between the experimental group of animals on the bases of the number of axons, axon diameter, and nerve diameter. Moreover, up 30th day of the experimental period our functional test results have shown that there was no difference between the groups. But following the induction of the injury, the statistical significances were seen on the functional tests. This effect was seen only if the multi-dose application of the dex. Conclusions: This study suggests that; dexketoprofen trometamol of 5 consecutive days, has revealed positive significant changes in the sciatic nerve injury through analgesic effect of it.Öğe Effects of Intracisternal Dexmedetomidine on Cerebral Neuronal Cells in Rat: A Preliminary Study(Turkish Neurosurgical Soc, 2013) Kose, Emine Arzu; Bakar, Bulent; Kasimcan, Omur; Atilla, Pergin; Kilinc, Kamer; Muftuoglu, Sevda; Apan, AlpaslanAIM:The aim was to investigate whether dexmedetomidine had a toxic effect on cerebral neurons when it was administered centrally into the cerebrospinal fluid by the intracisternal route. MATERIAL and METHODS: Eighteen rats were anesthetized and the right femoral artery was cannulated. Mean arterial pressures, heart rates, arterial carbon dioxide tension, arterial oxygen tension, and blood pH were recorded. When the free cerebrospinal fluid flow was seen, 0.1 ml normal saline (Group SIC, n=6) or 9 mu g/kg diluted dexmedetomidine in 0.1 ml volume (Group DIC, n=6) was administered into the cisterna magna of rats. After 24 hours, the whole body blood was collected for measurement of plasma lipid peroxidation (LPO) levels. The hippocampal formations used for histopathological examination and measurement of tissue LPO levels. RESULTS: There was a statistically significant difference between the DIC/SIC groups and DIC/CONTROL groups regarding the brain LPO levels (p=0.002, p<0.001, respectively). Plasma LPO levels were statistically different between the CONTROL/DIC groups, CONTROL/SIC groups, DIC/ SIC groups (p=0.002, p=0.047, p=0.025, respectively),The picnotic neuron counts were different between the CONTROL/SIC groups, CONTROL/ DIC groups, DIC/SIC groups (p<0.001, p=0.001, p=0.024, respectively). CONCLUSION: In conclusion, dexmedetomidine had a toxic effect on cerebral neurons when it was administered centrally into the cerebrospinal fluid by the intracisternal route.Öğe Lumbar Disc Hernia and Erectile Dysfunction(Aves, 2011) Kaptan, Hulagu; Kulaksizoglu, Haluk; Kasimcan, OmurLumbosacral disc disease and sexual dysfunction are two non-lethal health entities that are common and decrease quality of life of patients. With interruption of communication between the brain and the penis, erectile dysfunction should be expected. However, there are very limited data on the interaction of lumbosacral disc disease and sexual functioning. The aim of this review is to highlight the association between lumbosacral disc disease and sexual dysfunction and to overview the diagnosis and treatment options for this subset of patients. (Archives of Neuropsychiatry 2011; 48 Supplement 1:31-4)Öğe Mature Teratoma Arising From The Anterior Fossa In An Adult(Nobel Ilac, 2011) Kaptan, Hulagu; Kasimcan, Omur; Cakiroglu, Kutay; Kilic, CelalGerm cell tumors may be classified as germinomas, which represent approximately two thirds of all intracranial germ cell tumors, and non germinomas, which include embryonal carcinomas, choriocarcinomas and teratomas. Teratoma may be mature(benign) or immature (malignant). Mature teratomas located in the anterior fossa are extremely rare and have benign characters. Nongerminomatous germ cell tumors, especially teratomas and choriocarcinomas, tend to occur in younger children. Mature teratoma in adults is very rare. In this paper we report a twenty-eight years old patient with mature teratoma in anterior fossa and pneumocephaly.Öğe The mechanism behind rarely-encountered subdural hygroma formation following foramen magnum decompression(Edizioni Minerva Medica, 2017) Antar, Veysel; Baran, Oguz; Kasimcan, Omur; Tasdemiroglu, Erol…Öğe Protective Effects of Methotrexate and Tenoxicam in Peridural Fibrosis in Rat Laminectomy Model(Journal Neurological Sciences, 2015) Kasimcan, Omur; Kaptan, Hulagu; Aktas, Savas; Bakar, Bulent; Karabagli, HakanObjective: Peridural fibrosis after laminectomy is an important surgical problem. Tenoxicam is a nonsteroidal antiinflammatory drug and an oxicam derivative acting by inhibiting the formation of prostaglandin and eicosanoids. Low dose methotrexate which has been used as an antiinflammatory agent rhomatoid arthritis inhibits the synthesis of potentially toxic compounds those accumulate in inflamed tissues. The aim of this study was to evaluate and compare the efficacy of these two independent pharmacological agents in the inhibition of peridural fibrosis. Methods: L3-4-5 bilateral laminectomy with sparing the dura mater integrity was perfomed to 30 male Wistar albino rats. Except the SHAM group, low dose methotraxate (0.2 mg/kg) or tenoxicam (0.5 mg/kg) was administered on the dura mater before the surgical closure. After 42 days, all rats were euthanized and their spinal columns performed laminectomy were removed for the histopathological evaluation. Results: The peridural fibrosis grades of the groups administered low dose methotrexate or tenoxicam were lower than SHAM group grades. They have lower fibroblast counts than SHAM group numerically, although there was no statistically significant difference among groups. Conclusion: Local usage of low dose methotrexate and tenoxicam may be helpful option for prevention of peridural fibrosis after laminectomy procedures in future.
