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Öğe Determination Of Veterinary Drug Residues In Sea Water, Sediment, And Natural Fish In The Aegean Sea(Parlar Scientific Publications (P S P), 2014) Baydan, Emine; Kaya, Sezai; Cagirgan, Hasmet; Yildirim, Ebru; Altintas, Levent; Yurdakok, Begum; Kucukosmanoglu, Asli GulIn this research, residues of certain veterinary drugs (florfenicol (FF) and florfenicol amine (FFA)) were screened in natural fish, sediment, and seawater samples of the Aegean Sea, while only chloramphenicol (CAP) was searched for in the sediment. Samples were collected from fish farming cages in selected coordinates (Bodrum, Salihli Region, Turkey) on September, October 2011 and March, April 2012. Method validation and analyses were carried out by HPLC method. For FF; LOD values were 25.11 ppb for sea water, 27.07 ppb for sediment as well as 38.16 and 37.95 ppb for Mullus barbatus and Oblada tnelanura fish samples. FFA value for Mullus barbatus was 39.60 ppb, respectively. For CAP in sediment samples, LOD values were found as 53.59 ppb. In 4 different sampling areas (A, B, C, D), the lowest temperature was recorded as 14 degrees C in March 2012 but the highest was 28.3 degrees C in October 2011; the lowest dissolved oxygen (mg/L) values were detected in March 2012 (from 6.05 to 6.44), the highest in October 2011(10.78-11.55). The pH values slightly varied month by month; the lowest was 7.9 and the highest 8.6. This research revealed that dissolved oxygen and pH values of the collected seawater samples were in accordance with the normal limits of the offshore seawater values; no significant residue of the analyzed veterinary drugs was found to be present, and all values were found to be lower than LOD values in the sampled fish farms. In conclusion; there was no pollution caused by veterinary drugs.Öğe Investigation of some veterinary drug residues in sea water, sediment, and wild fishes captured around fish farms in the Aegean Sea: Oxytetracyline, ivermectin and emamectin(Ankara Univ Press, 2015) Baydan, Emine; Kaya, Sezai; Cagirgan, Hasmet; Yildirim, Ebru; Altintas, Levent; Yurdakok, Begun; Kucukosmanoglu, Asli GulVeterinary drug residues and their metabolites in food are regularly investigated by local authorities; however their fate in the environment is still unknown. Despite the importance of the aquaculture industry and the widespread use of antibiotics; limited scientific information regarding their residue in natural fish, sediment and sea water are available in TURKEY. The current study; which is the first study in this area, was undertaken to determine the oxytetracycline (OTC), ivermectin (IVM) and emamectin benzoate (EMA) residues from samples of wild fishes (Oblada melanura, Mullus barbatus), sea water and sediment collected in four different months, caught around the fish cages near Salihli Island in Bodrum, Aegean Sea. Samples were analyzed by High Pressure Liquid Chromatography (HPLC) followed by the validation for each matrix. No residues were found to be above the Limit of detection (LOD) levels of the validated methods in the screened samples. In order to understand the possible risk of veterinary antibiotics, especially for low dose accumulation, to the ecosystem for sustainable aquaculture, conduction of more screening analysis with expanded possible matrices would be beneficial.