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Öğe A Case of Miliary Tuberculosis Detected with Laryngeal Oedema: Complication with Septic Shock and Thrombocytopaenia(Aves, 2013) Bulcun, Emel; Ekici, Aydanur; Ekici, Mehmet; Gulhan, Pinar Yildiz; Gungor, Omur; Kazkayasi, MustafaTuberculosis, a disease with a wide clinical spectrum, can involve all tissues and organs. A 57-year-old case appeared in the form miliary tuberculosis after laryngeal oedema. Septic shock developed in the course of tuberculosis. Thrombocytopaenia then developed, while septic shock improved following antituberculosis treatment. Thrombocytopaenia improved after rifampicin was removed from the treatment regimen. We decided to present our case here as an interesting form of tuberculosis with complications.Öğe Acute actinic cheilitis-like chemical irritant reaction following accidental contact with ethylene glycol - Favorable response to topical 1% pimecrolimus cream: A case report(Taylor & Francis Inc, 2008) Erkek, Emel; Kazkayasi, Mustafa; Bozdogan, OnderEthylene glycol is a colorless, odorless, nonvolatile, water-soluble fluid, mainly used as automobile antifreeze and coolant. This substance is a frequent culprit in accidental and intentional poisonings. Although potentially fatal systemic consequences of ethylene glycol ingestion are well known, local adverse effects through brief skin and mucosa contact with ethylene glycol have been rarely reported. Herein we report a patient with accidental ethylene glycol contact to the lower lip, who presented with acute, manifest, actinic cheilitis-like chemical irritant reaction and favorably responded to topical pimecrolimus 1% cream.Öğe Effect of musical training on musical perception and hearing sensitivity: Conventional and high-frequency audiometric comparison(B C Decker Inc, 2006) Kazkayasi, Mustafa; Yetiser, Sertac; Özçelik, SadıkThis prospective study was designed to investigate the role of musical training on musical perception and hearing acuity and to determine probable hearing loss. Thirty students, aged 17 to 23 years, were evaluated for hearing sensitivity within conventional and high-frequency audiometric ranges. The hearing thresholds of the controls were compared with those of the students. To evaluate the effect of musical training on musical perception, students were given an examination consisting of single-note, harmonic hearing; multiple sounds (chords with two, three, and four sounds), horizontal hearing; melody, and rhythm. Musical perception and the average hearing level of the students on admission to the faculty were compared with the data from students after a 2-year musical education program. The hearing sensitivity of the students at the initial and final evaluations was not similar. The average hearing acuity increased for the whole conventional audiometric range (p <.05). There was worsening for 12, 14, and 16 kHz for the high-frequency audiometric range (p <.05). The decrease in average hearing acuity at these frequencies was statistically significant, as indicated by Student's t-test (p <.05). Although the average musical hearing sensitivity increased for horizontal hearing (p <.05), it did not change for harmonic hearing (p >.05). Musical training might increase the spontaneous attention to the sound heard and the ability to discriminate. Hearing reduction at the high frequencies might be attributed to continuous noise exposure.Öğe Effects of Septoplasty on Pulmonary Function Tests in Patients with Nasal Septal Deviation(Bmc, 2010) Bulcun, Emel; Kazkayasi, Mustafa; Ekici, M. Aydanur; Tahran, Filiz Datli; Ekici, MehmetObjective: To investigate the effects of septoplasty on pulmonary function tests (PFTs) and bronchial hyperresponsiveness (BHR) in patients who had no previous pulmonary diseases. Design: Prospective, controlled clinical trial. Patients: Fourteen patients with nasal septal deviation (NSD) and 20 controls were enrolled in the study. Main Outcome Measures: All patients were evaluated with anterior rhinoscopy, nasal endoscopy, acoustic rhinometry (AR), visual analogue scale (VAS), PFTs, and bronchoprovocation test (BPT) on the day before surgery and 8 to 12 weeks after surgery. Results: The postoperative values of forced expiratory volume in 1 second, forced vital capacity, and peak expiratory flow percentages were higher than preoperative ones, and these results were statistically significant (p = .007, p = .04, and p = .007, respectively). Nine patients had preoperative BHR, and three of them had negative BPT postoperatively. When compared with the preoperative values, there was a borderline decrease in the rate of BHR in six patients. There were significant improvements in the symptoms of left and right nasal congestion, headache, postnasal drip, and olfactory function after surgery. We found important improvement in the values of AR at right minimal cross-sectional area 1 (p = .02), left distance 1 (p = .04), and left distance 2 (p = .04) postoperatively. Conclusion: An improvement in both nasal symptoms and PFT values was seen after surgical treatment for NSD. We concluded that septoplasty may be considered as having favourable effects on BHR.Öğe High-Dose Ropivacaine versus Bupivacaine for Posttonsillectomy Pain Relief in Adults(Bmc, 2008) Arikan, Osman Kursat; Şahin, Saziye; Kazkayasi, Mustafa; Muluk, Nuray Bayar; Akpinar, Serpil; Kilic, RahmiObjective: To compare the efficacy and safety of preincisional high-dose ropivacaine with bupivacaine in relieving posttonsillectomy pain. Design: A prospective, randomized, double blind, placebo-controlled clinical trial. Setting: University hospital. Patients: Before the incision, 58 subjects were randomly assigned to receive 10 mL of 10 mg/mL ropivacaine hydrochloride with epinephrine (n = 19, group 1), 10 mL of 2.5 mg/mL bupivacaine with epinephrine (n = 20, group 2), or saline with epinephrine (n = 19, group 3) as a placebo. Main Outcomes Measures: Postoperative pain, additional analgesic drug consumption, otalgia, operating time, amount of intraoperative blood loss, and possible complications were assessed. The intensity of pain was scored on a visual analogue scale. The patients were followed up for 10 days after surgery. Results: There were no statistically significant differences between the demographic and operational characteristics of the patient groups. Statistically significant differences were determined between in the mean intensity of constant and swallowing pain values of group 1 and group 2 or 3, at 4, 8, and 12 hours, and on days 1, 2, 3, and 4, postoperatively. However, no statistical differences were determined between the groups on days 5, 7, and 10. A lower amount of additional analgesic drug was consumed by the ropivacaine group than by the bupivacaine group, and by the bupivacaine group than by the control group, and the differences were statistically significant. Conclusion: Preincisional infiltration of the tonsils with high-dose ropivacaine markedly decreased the intensity of pain after tonsillectomy when compared with bupivacaine or placebo, especially until postoperative day 4 in adults.Öğe Magnesium sulphate infusion is not effective on discomfort or emergence phenomenon in paediatric adenoidectomy/tonsillectomy(Elsevier Ireland Ltd, 2010) Apan, Alparslan; Aykaç, Esra; Kazkayasi, Mustafa; Doğancı, Nur; Tahran, Filiz DatlıObjective: This study was performed to evaluate the possible influence of magnesium sulphate which has sedative and analgesic properties on sevoflurane-induced emergence agitation in paediatric patients undergoing adenoidectomy with or without tonsillectomy. Methods: One hundred and ten paediatric patients aged between 3 and 16 years were randomly allocated to the study. Propofol 2-2.5 mg kg(-1), vecuronium 0.1 mg kg(-1) and fentanyl 1 mu g kg(-1) were used for induction of anesthesia and sevoflurane at 1 MAC with nitrous oxide in oxygen (35%) mixture was administered as maintenance. Magnesium sulfate 30 mg kg(-1) in saline (20 mL) in the Group M, or equal volume of saline for controls (Group C) was started 10 min before and infused until the end of the operation. Recovery characteristics included time to extubation, eyes open, emergence and interaction. Patients were evaluated using Modified Aldrete Score (MAS), Pain/Discomfort Scale and Agitation Score. Side effects were determined during emergence and in the recovery. Results: Time to open eyes was significantly higher in the magnesium treatment group (Group C: 7.7 +/- 3.5, Group M: 12.7 +/- 17.5 min, p = 0.001). Agitation score was significantly lower in Group M at the 60th min (Group C: 1.3 +/- 0.7, Group M: 1.0 +/- 0.3, p = 0.005). Agitation or pain/discomfort scores in the resting observation periods were the same. The initial MAS value was lower in Group M (Group C: 5.0 +/- 1.9, Group M: 4.0 +/- 1.7, p = 0.003). There was no significant difference between groups regarding side effects. Conclusion: Magnesium sulphate infusion has no influence on sevoflurane-induced discomfort or emergence agitation. (C) 2010 Elsevier Ireland Ltd. All rights reserved.Öğe Preincisional infiltration of tonsils with ropivacaine in post-tonsillectomy pain relief: double-blind, randomized, placebo-controlled intraindividual study(B C Decker Inc, 2006) Arıkan, Osman Kürşat; Özcan, Şaziye; Kazkayasi, Mustafa; Akpinar, Serpil; Koç, CanObjective: To determine whether pre-emptive ropivacaine has an influence on postoperative pain in adult patients undergoing tonsillectomy. Design: A prospective, randomized, double-blind, placebo-controlled clinical trial. Setting: University hospital. Patients: The study included 20 adult patients undergoing elective tonsillectomy. Anesthetic induction and maintenance, dissection tonsillectomy, hemostasis techniques, and postoperative analgesic treatment were standardized for all patients. Before the onset of incision, one tonsillar fossa was administered 5 mL of 2% ropivacaine hydrochloride with epinephrine, whereas the other side received 5 mL of 0.9% saline with epinephrine and was designated as the control side. Main Outcomes Measures: For each side, postoperative pain, otalgia, operating time, amount of intraoperative blood loss, and postoperative hemorrhage were assessed. The intensity of postoperative pain was measured at rest and when the patient was drinking and was scored on a visual analogue scale. The patients were followed up for 10 days after surgery. Results: There was no statistically significant difference in the amount of intraoperative hemorrhage and operation time between sides (p >.05). The constant postoperative pain in the ropivacaine side at rest was significantly less than in the placebo side on days 1, 2, 5, and 6 (p <.05). The post-tonsillectomy pain experienced in the ropivacaine side when swallowing was significantly less than that in the placebo side throughout the study period except on day 10 (p <.05). Conclusion: Based on the present findings, preincisional infiltration of ropivacaine 2% appears to be effective against both early and late postoperative pain, especially on swallowing, following tonsillectomy in adults.Öğe Tangier disease in a Turkish family(Wiley-Blackwell, 2014) Sahiner, Neriman; Kocak, Mukadder; Demirceken, Fulya; Kisa, Ucler; Ayva, Sebnem; Kazkayasi, MustafaIn this report we describe the upper gastrointestinal tractus involvement in a rare genetic disease of lipid metabolism. A 12-year-old boy presented with sore throat and fever. On physical examination, orange-yellow tonsils and adenoid tissue were noted. Mild hepatosplenomegaly was present. Lipid profile was compatible with Tangier disease (TD). Endoscopy of the upper gastrointestinal tract showed white-yellowish fatty deposits on the gastric mucosa. Microscopically, biopsy specimens contained numerous histiocytes with a foamy cytoplasm packed in the lamina propria of the gastric mucosa and at the crypt basement of the duodenum. His sister, 8 years old, was also diagnosed with TD based on abnormal lipid profile and orange-yellow tonsils. TD is a rare familial disorder of lipid metabolism, characterized by deposition of cholesteryl esters, probably involving the entirety of the gastrointestinal tract from the mouth to the anus.Öğe The Effects of Platelet-Rich Plasma and Platelet-Rich Fibrin on Rabbit Auricular Cartilage Regeneration(Turkiye Klinikleri, 2024) Karaçayli, Ceren; Karahan, Siyami; Kazkayasi, Mustafa; Kiliç, RahmiObjective: This study aims to examine the impact of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the repair of cartilage tissue. The objective is to discover if these materials effectively boost the healing ability of cartilage tissue. Material and Methods: The study consisted of 18 male rabbits from New Zealand, all of whom were adults and white in color. The rabbits were partitioned into three study cohorts, each consisting of six rabbits. The study group was partitioned into subgroups A and B, each consisting of three rabbits. Cartilage of 10×10 mm2 was surgically removed from the ears of rabbits in all A subgroups. A 1 mm section of cartilage was removed from the outer edge of the excised cartilage to decrease its dimensions. The 8×8 mm cartilage acquired from the initial group was positioned in the exact location from whence it was extracted. Within all B subgroups, a section of cartilage measuring 10×10 mm2 was extracted from the ears of rabbits. In the initial cohort, a volume of 2 milliliters of PRP was administered onto the mucoperichondrium at the site where the cartilage was excised. In the second group, PRF was applied to the site where the cartilage was excised. No intervention was conducted on the area where cartilage was removed in the third group. A scoring system was used to evaluate degenerative changes in microscopic cartilage analysis. Results: There was no significant difference between the groups in terms of cartilage healing. Conclusion: PRP and PRF don’t improve healing of the cartilage tissue in ear. © 2024 Turkey Association of Society of Ear Nose Throat and Head Neck Surgery. Production and hosting by Türkiye Klinikleri.Öğe Uncinate Process in the Repair of Nasoseptal Perforation(Springer, 2011) Kazkayasi, Mustafa; Yalcinozan, Eda TunaSeptal perforation is an anatomical defect of the nasal septum. Prior septal surgery is the most common reason of this defect. Because repair of a nasoseptal perforation is a challenging surgical procedure, many techniques have been discussed for decades. This article considers the first case of nasoseptal perforation repair using the overmedialized uncinate process. The main aim of this study is to report on the usability and efficiency of regional autogenous grafts in the repair of nasoseptal perforations.
