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  • Küçük Resim
    Öğe
    Pathomorphologic Characteristics of Non-Neoplastic Lesions in Bovine Urinary Bladders
    (2018) Keleş, Hikmet; Bozkurt, Mehmet Fatih; Özyıldız, Zafer; Alçığır, Mehmet Eray
    Non-neoplastic epithelial and stromal changes might be prognostic in early phase of premalignant neoplastic developments of urinary bladder. In this regard, diagnosis and histological classification of these lesions give valuable knowledge for prevention and treatment in both human and veterinary medicine. In Turkey, bovine urinary bladder lesions have been encountered in great ratio even though the small numbers of cases have been observed in other animals. According to our great experiences and field-studies for years concentrating on the topic, inflammatory and neoplastic of pathologies in urinary bladders might be easily developed after long term Bracken fern-consuming cattle. In current study, non-neoplastic cases including mainly epithelial, stromal, vascular, and inflammatory characteristic lesions were identified and described separately. Degenerative, desquamative, cystic, hyperplastic, and metaplastic lesions were found prominently in urinary bladder epithelium. Consecutive lesions comprised stromal changes and vascular lesions characterized with circulatory problems. Accompanying those, remarkable mononuclear cell infiltrations were found in a lot of cases. In conclusion, such kind of non-neoplastic lesions at least should be considered as important as neoplastic lesions because the lesions can have a risk in course of premalignant neoplastic transformation.
  • Küçük Resim
    Öğe
    Topical application of olive oil macerate of Momordica charantia L. promotes healing of excisional and incisional wounds in rat buccal mucosa
    (Pergamon-Elsevier Science Ltd, 2015) İlhan, Mert; Bolat, İsmail Eser; Suntar, İpek; Koklu, Harika Kutluay; Cankal, Dilek A. Ugar; Keleş, Hikmet; Akkol, Esra Küpeli
    Objective: In Turkish folk medicine Momordica charantia L. is used for wound healing. The aim of the present study is to investigate this folkloric knowledge and confirm the plant's potential effect on buccal mucosa wound in the rat. Design: Wound healing activity of olive oil macerate of Momordica charantia L was investigated in linear incision and circular excision wound models created in the buccal mucosa of the rat. The tissues were histopathologically evaluated, moreover, hydroxyproline contents of the tissues were determined. The anti-inflammatory activity was also assessed by using Whittle method with some modifications. Results: Olive oil macerate of M. charantia showed significant wound healing activity both in incision (45.1%) and excision (89.8%) wound models and demonstrated anti-inflammatory activity with the inhibition value of 31.3% at the dose of 100 mg/kg. Conclusion: The experimental data revealed that M. charantia showed significant wound healing and anti-inflammatory effect. (C) 2015 Elsevier Ltd. All rights reserved.