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    Evaluation of immunohistochemical expression of GSTA1 and GSTP1 isoenzymes before and after treatment of Trx and L-NAME in experimental hepatic ischemia/reperfusion model
    (Society of Pharmaceutical Sciences of Ankara (FABAD), 2012) Güler Şimşek G.; Kiliç M.; Oğuz?üzun S.; Karahan S.; Akin O.K.; Kiliç N.; Serdar M.A.
    Ischemia/reperfusion (I/R) causes formation of Reactive Oxygen Species (ROS) in tissues, in response to which injured cells improve a number of defense mechanisms including Glutathione S-Transferases (GSTs). The aim of this study was to investigate the expressions of GSTA1 and GSTP1 following Thioredoxin (Trx) and N-nitro-L-arginine methyl ester (L-NAME) treatment in a rat model of hepatic I/R model. A total of 50 Wistar rats were randomly allocated into 5 groups: sham (n = 10), control (I/R) (n = 10), Trx (n = 10), L-NAME (n = 10), and Trx+L-NAME (n = 10). With an exception to those in sham group, all rats were subjected to a hepatic ischemia process for an hour and then subsequent reperfusion. GSTA1 and GSTP1 expressions in the liver tissues were determined by immunohistochemical method. The GSTA1 expression was absent in sham group while varying degrees of expression occurred in other groups. The GSTA1 expression was significantly higher in Trx/L-NAME group compared to other groups (p <0.05). GSTP1 expression was no difference between groups (p >0.05). As a result, we think that GSTA1 expression may have increased in response to I/R as a part of the liver oxygen radical scavenging process.
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    Öğe
    Measuring the surface roughness values of european hop-horn beam (Ostrya carpinifolia scop.) wood
    (Statny Drevarsky Vyskumny Ustav, 2018) Kiliç M.; Pürlusoy I.; Kurnali M.
    In this study, the samples obtained from European hop-horn beam (Ostrya carpinifolia Scop.) wood has been subject to cutting with circular saw, planing with a thickness machine and sanding with a caliber sanding machine (with no: 80 sand). After the specimens were processed in the machines in radial and tangential surfaces, their surface roughness values (Ra, Ry, Rz) have been determined in accordance with the ISO 4288 standard. According to the statistical results, the lowest roughness values have been achieved with the thickness machine. Similarly, the roughness values of tangentially cut surfaces have been found to be lower than the radially cut surfaces. © 2018 Statny Drevarsky Vyskumny Ustav. All rights reserved.