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Öğe Candida colonisation within a silicone tissue expander(Churchill Livingstone, 2002) Saray, A.; Kaygusuz, S.; Kisa, Ü.; Kilic, D.The fungal contamination of tissue expanders is rarely reported. There are, however, occasional reports of fungi in association with inflatable mammary implants. We describe the colonisation of a tissue expander with Candida albicans, resulting in the fluid becoming a turbid brown colour. The possible modes of inoculation and survival of the microorganism within the expander shell were investigated by means of biochemical and microbiological analyses of the fluid. The colonisation of silicone implants by opportunistic fungi is probably more common than has been reported, and precautions that can be taken to avoid this complication are emphasised. (C) 2002 The British Association of Plastic Surgeons.Öğe Neopterin levels in nonreplicative HBV carriers(Elsevier Sci Ireland Ltd, 2002) Kilic, D.; Boyunaga, H.; Kaygusuz, S.; Akgul, E.O.; Al Rashed, M.; Kenar, L.; Kutluay, T.The aim of this study was to determine the existence of immune activation by measuring neopterin in HBV (Hepatitis B virus) carriers with viral load (HBV DNA) less than 5 pg/ml. Forty-three subjects and 56 healthy controls were included in the study. Neopterin levels of were compared. ALT and ALP levels in one patient and AST levels in two patients were found minimally higher than upper limit, and GGT levels were within the reference range in all patients. Neopterin levels in the patient group and in the controls were 159.97 +/- 13.39 and 84.10 +/- 11.45 nmol/l, respectively (P < 0.0001). The difference between the two groups was statistically significant (P < 0.0001). In conclusion, the increased neopterin levels of HBV carriers might be the indicators of the effect of cellular immunity. This increase might also implicate a background inflammation based on mainly cellular immunity that exists within the liver. (C) 2002 Elsevier Science B.V. All rights reserved.Öğe Prognostic implications of microscopic proximal bronchial extension in non-small cell lung cancer(Elsevier Science Inc, 2002) Kara, M.; Dikmen, E.; Kilic, D.; Sak, S.D.; Orhan, D.; Köse, S.K.; Kavukcu, S.Background. The loss of approximately one third of early stage lung cancer patients undergoing complete resection by the end of 5 years implies the existence of unknown or undetected factors at the time of operation. We investigated the possible correlation between microscopic proximal bronchial extension (MPBE) and survival with clinicopathologic features in patients with non-small cell lung cancer. Methods. The bronchial tree with the tumor was dissected and extracted from the lung parenchyma in a total of 62 surgical specimens with non-small cell lung cancer. The tumor-related bronchus was sectioned into serial blocks at a thickness of 5 mm in the transverse plane. Histologically, cut serial sections were examined for MPBE. Results. A total of 15 (24.2%) specimens showed MPBE, whereas 47 (75.8%) specimens showed no evidence of MPBE. The median survival time of MPBE-positive patients was 10.0 months, whereas that of MPBE-negative patients was 42.0 months. The 5-year survival rates of MPBE-positive and MPBE-negative groups were 13.3% and 35.8%, respectively, which was a significant difference (P = 0.0203). Multivariate analysis revealed lymph node status (p = 0.0161), histology (p = 0.0268), and MPBE-positivity (p = 0.0447) as independent prognostic factors. Conclusions. Microscopic proximal bronchial extension has an adverse effect on survival in non-small cell lung cancer.Öğe Seroprevalence of tetanus immunity among noninsulin-dependent diabetes mellitus patients(Elsevier Science Inc, 2003) Kilic, D.; Kaygusuz, S.; Saygun, M.; Cakman, A.; Uzer, H.; Doganci, L.Tetanus is a preventable disease that continues to affect people in both developing and developed countries. The aim of the present study was to evaluate the immunity profile to tetanus in patients with Type II diabetes mellitus (DM) and to compare them with healthy controls. The tetanus antitoxin levels in 310 diabetic patients (104 males and 206 females) and in 200 healthy controls (72 males and 128 females) were measured by ELISA (Virotech, Germany). The mean antitoxin concentration in patient and control groups were 0.8238+/-1.61 and 0.9978+/-1.49 IU/ml, respectively. There was a statistically significant difference between the two groups (z = -3.520, P = .0001 and odds ratio was 2.367). There was a definitive inverse correlation between the duration of diabetes and tetanus antibody titers (Spearman's correlation analysis, r = -.155, P = .006). A gender-dependent difference in the susceptibility to tetanus was present in the diabetic group with antibody titers being significantly higher in males compared with females (z = -2.267, P = .023). For both of control (chi(2) = 20.207, P = .003) and patient (chi(2) = 43.532, P = .0001) groups, there was a significant inverse correlation between the tetanus immunity levels and age. Statistically, a significant drop in antibody titers of both groups was found as the period past from the last immunization increased (Pearson correlation analysis: for patient group r = -.364, P = .0001; for control group r = -.143, P = .044). The tetanus antitoxin levels were significantly increased in individuals who had primary immunization during childhood (for patient group chi(2) = 17.191, P = .0001; for control group chi(2) = 9.911, P = .007). A significant reduction in the level of antitoxin immunity to tetanus in association with an increased susceptibility to infections in patients with diabetes may implicate the need for improving vaccination rates in this patient group. (C) 2003 Elsevier Inc. All rights reserved.
