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    Association of Low Serum Maresin-1 Levels with Hepatocellular Carcinoma in Cirrhotic Liver
    (Verlag Klinisches Labor GmbH, 2024) Ergül, Bilal; Gül, Özlem; Kisa, Üçler; Erdal, Harun; Tekin, Ercan; Oğuz, Dilek
    Background: Maresin-1 (MaR1) is a macrophage-derived antiinflammatory lipid mediator that negatively regulates oxidative and proinflammatory cytokines and also restores integrity in various tissues after inflammation. Non-resolving inflammation is known to have an important role in the pathogenesis of hepatocellular carcinoma (HCC). The aim of the present study was to evaluate the role of MaR1 in pathogenesis and early diagnosis of HCC. Methods: The study was conducted in 102 participants, including 30 volunteers with no hepatic disease, 39 patients with hepatic cirrhosis, and 33 patients with HCC that developed additionally to cirrhosis. Serum MaR1 levels of all participants were measured by enzyme-linked immunosorbent assay (ELISA). Results: There was a significant difference between the circulating MaR1 levels of the three groups. MaR1 level was found to be significantly lower in the HCC group compared to the cirrhotic group (p < 0.001) and in the cirrhotic group compared to the healthy control group (p < 0.001). MaR1 level was independently associated with cirrhosis (vs. controls, OR: 0.995, p = 0.025) and with HCC (vs. controls, OR: 0.962, p = 0.035; and vs. cirrhotic patients, OR: 0.987, p = 0.006). ROC analyses demonstrated that MaR1 levels of < 311.66 had 72.73% sensitivity and 100% specificity for HCC differentiation from controls, while a < 428.08 cutoff had 96.97% sensitivity and 38.46% specificity for differentiation from cirrhotic patients. Conclusions: Serum MaR1 levels were significantly decreased in patients with HCC, compared to those with normal or cirrhotic hepatic tissue. Therefore, MaR1 may possibly be a valuable biomarker in the early diagnosis of HCC and in the differential diagnosis of HCC from cirrhosis. ©Copyright.
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    Öğe
    Could maternal serum MFG-E8 level predict adverse first trimester pregnancy outcome? A preliminary study
    (Turkiye Klinikleri, 2023) Elçi, Bircan; Yalçinkaya, Zeynep; Tekin, Ercan; Bakirci, Şükrü; Dayangan Sayan, Cemile; Kisa, Üçler; Kurdoğlu, Mertihan
    Background/aim: Milk fat globule-epidermal growth factor 8 (MFG-E8) is expressed in the endometrial epithelium and its expression increases during the implantation process. Due to this knowledge, we aimed to investigate the maternal serum MFG-E8 levels on both healthy pregnant women in the first trimester and pregnant women complicated with missed abortion and threatened abortion in the first trimester. Materials and methods: This prospective, cross-sectional study was conducted in a tertiary referral hospital, department of obstetrics between July 2020 and February 2021 after ethical committee approval. The study population was consisted of 30 healthy pregnant women (HP) in the first trimester, 30 pregnant women suffering from threatened abortion (TA) in the first trimester and 30 pregnant women suffering from missed abortion (MA) in the first trimester. Maternal serum MFG-E8 levels were analyzed with enzyme linked immunosorbent assay. Delivery and neonatal outcomes of the study population was evaluated. The continuous variables were compared among three groups with variance analysis with post hoc tests. The categorical variables were compared with chi-square and Fisher’s exact tests where applicable. Results: The mean age of the study population was 29.36 ± 5.31 years. There was no significant difference among three groups for parameters of age, body mass index, parity number, and gestational week. Despite being within normal ranges, the mean neutrophil and international normalized ratio values of the three groups showed statistically significant difference (p < 0.05). The mean maternal serum MFG-E8 levels of MA, TA, and HP groups were 270 ± 152.3, 414.7 ± 236.7, and 474 ± 222.5 ng/mL, respectively (p = 0.001). It was found that mean of MFG-E8 of the MA group was statistically significantly lower than those of the other two groups (p < 0.05). Conclusion: Although maternal serum MFG-E8 level seems to be a parameter that differ between live and nonlive pregnancies, studies with large number of cases are needed to discuss our results and to determine a cut-off value for prediction. © TÜBİTAK.