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Öğe Anti-Mullerian hormone predicts affected sisters of patients with PCOS(Oxford Univ Press, 2012) Cil, A. P.; Guler, Z. B.; Kisa, U.…Öğe Apelin 13: A promising biomarker for multiple sclerosis.(Sage Publications Ltd, 2016) Alpua, M.; Turkel, Y.; Dag, E.; Kisa, U.…Öğe Determination of oxidant and antioxidant levels in children with thrombocytosis(Pergamon-Elsevier Science Ltd, 2018) Albayrak, M.; Demirkol, N.; Kisa, U.…Öğe Dietary fatty acid pattern and preferences are not associated with fatty acid transporter CD36 in diabetic patients(Wiley-Blackwell, 2016) Sakioglu, E. M.; Kisa, U.; Durmaz, S. Arikan; Unal, R. Nergiz…Öğe Effect of synbiotics in the treatment of smokers and non-smokers with gingivitis: randomized controlled trial(WILEY, 2020) Ercan, N.; Olgun, E.; Kisa, U.; Yalim, M.Background To evaluate the efficacy of synbiotic tablets on the clinical and biochemical parameters of smokers and non-smokers with gingivitis. Methods Eighty patients with gingivitis [40 smokers (+), 40 non-smokers (-)] were randomly assigned to test (T) or control (C) groups. Four groups were defined: T(+), T(-), C(+) and C(-). The subjects daily chewed a synbiotic or placebo tablet for 30 days. The gingival crevicular fluid levels of interleukin (IL)-6, IL-8 and IL-10 were determined as the primary outcome variables. Results The clinical and biochemical parameters for all groups significantly reduced compared with the baseline (P < 0.05). While there were no significant differences between the groups for gingival index, the plaque index was significantly higher in both smoker groups than that in the T(-) group during the second month (P < 0.05). IL-8 levels in C(-) and IL-6 levels in both control groups were significantly higher than those in the T(+) group. The IL-10 levels in both control groups were significantly higher than those in the T(-) group during the second month (P < 0.05). Conclusions Adjunctive synbiotic tablets significantly reduce subclinical therapeutic outcomes for both smokers and non-smokers compared with placebo according to the biochemical parameters.Öğe Effect of Titanium-prepared Platelet-rich Fibrin Treatment on the Angiogenic Biomarkers in Gingival Crevicular Fluid in Infrabony Defects of Patients with Chronic Periodontitis: A Randomized Controlled Clinical Trial(Wolters Kluwer Medknow Publications, 2018) Pirebas, H. G.; Hendek, M. K.; Kisa, U.; Yalim, M.; Erdemir, E. O.Aim: The aim of this double-blinded, randomized, controlled clinical study was to investigate the effect of titanium-prepared platelet-rich fibrin (T-PRF) treatment on the angiogenic biomarkers in gingival crevicular fluid (GCF) in infrabony defects of patients with chronic periodontitis. Materials and Methods: Twenty five systemically healthy participants who complied with inclusion criteria with periodontal infrabony defects were recruited. In each patient, the infrabony defect of one side of arch was designated as control group (allograft), whereas the infrabony defect on the contralateral side of same arch was designated as test group (allograft + T-PRF). The therapy methods (test or control) were randomly decided. GCF samples were collected at baseline (presurgery) and then the 3rd, 7th, 14th, and 30th days after surgery. Platelet-derived growth factor (PDGF)-BB, vascular endothelial growth factor (VEGF)-A, fibroblast growth factor (FGF)-2, anjiogenin (ANG), angiostatin (ANT) in the GCF samples were measured using human enzyme-linked immunosorbent assay kits. Results: In both groups, total amounts of PDGF-BB, VEGF-A, FGF-2, ANG, and ANT peaked in the GCF samples obtained at the early postoperative day (day 3) and decreased over time in the samples obtained at the 7th, 14th, and 30th days postsurgery. There were no significant differences between groups for the total amounts of PDGF-BB, VEGF-A, FGF-2, ANG, and ANT at all evaluation periods. Conclusion: Application of T-PRF combined with allograft in infrabony defects of patients with chronic periodontitis had no significant effects on angiogenic biomarkers in GCF.Öğe The effects of ozone therapy on cavernosal damage due to ischemia / reperfusion injury induced priapism in rat models(Wiley-Blackwell, 2011) Basar, M.; Aydos, T.; Kul, O.; Atmaca, T.; Uzunalioglu, T.; Kisa, U.…Öğe Effects of the sulphasalazine to the cerebral hypoxia reperfusion injury in rat(Wiley-Blackwell, 2016) Cetin, C.; Erdogan, A. M.; Dincel, G. C.; Bakar, B.; Kisa, U.…Öğe Effects of thyroid hormone supplementation on oxidative stress after sleeve gastrectomy(Wiley-Blackwell, 2016) Basok, B. Isbilen; Orman, S.; Kisa, U.; Kahraman, N. Genc; Isman, F. K.…Öğe The impact of iron deficiency on blood cell volume(Pergamon-Elsevier Science Ltd, 2019) Yorguc, M.; Kisa, U.; Yorguc, E.; Albayrak, M.…Öğe Leptin resistance and genetic predisposition as potential mechanisms in the development of skin tags(Medcom Ltd, 2011) Erkek, E.; Kisa, U.; Bagci, Y.; Sezikli, H.Background and objective: The cause of skin tags (ST) remains elusive. The present study was designed to elucidate the role of leptin and to unravel other potential aetiological factors in the pathogenesis of ST. Methods: The study population comprised 58 patients with ST and 24 control individuals. Demographic and other variables were recorded. A detailed laboratory evaluation including serum leptin was performed. Results: Statistical analysis revealed significant differences between the two groups in terms of body weight, body mass index (BMI), family history of ST, triglyceride, cholesterol, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) and serum leptin levels. A family history of ST was the most important predictor of ST development by logistic regression analysis. Conclusions: These findings indicate that ST correlate with serum leptin levels and that leptin resistance may be involved in the pathogenesis of ST in susceptible individuals.Öğe Nesfatin-1 and caspase-cleaved cytokeratin-18: Promising biomarkers for Alzheimer's disease?(Comenius Univ, 2019) Alpua, M.; Kisa, U.OBJECTIVES: To investigate the use of nesfatin-1 and caspase-cleaved cytokeratin-18 serum levels as biomarkers in Alzheimer's disease. METHODS: The study group consisted of 39 patients with Alzheimer's disease (AD) and 39 controls. Demographic characteristics including gender, age, body mass index, mini-mental status examination (MMSE) and duration of disease were recorded. The ELISA method was used to measure serum nesfatin-1 and CCCK-18 levels in serum samples. RESULTS: Serum nesfatin-1 levels were statistically significantly higher in the AD patient group than in controls. There was no significant difference between the groups with regards to serum CCCK-18 levels. Pearson analysis showed no significant correlation between serum nesfatin-1, serum CCCK-18 levels, mini-mental status examination and disease duration. CONCLUSION: This study proved that serum nesfatin-1 levels can be used as a biomarker in Alzheimer's disease by showing a statistically significant high level of serum nesfatin-1 in patients with Alzheimer's disease. This is the first study to suggest that nesfatin-1 can be used as a biomarker in Alzheimer's disease. In addition, our study showed that CCCK-18 can be used as a prognostic biomarker for Alzheimer's disease. Further comprehensive studies should be done to clarify the use of serum nesfatin-1 and CCCK-18 levels as biomarkers for Alzheimer disease (Tab. 3, Fig. 2, Ref. 25).Öğe Pathological, clinical and biochemical investigation of naturally occuring pregnancy toxemia of sheep(Veterinary Faculty, 2003) Kabakci, N.; Yarim, G.; Yarim, M.; Duru, O.; Yagci, B.B.; Kisa, U.A sick ewe in late pregnancy presented with clinical incoordination, lipping, amaurosis, head tilt gait and nervous symptoms such as circling movements. A smell of ketones on the breath was detected. The sick animal died during clinical examination and, together with three more dead animals belonging to the same flock, was submitted to the laboratory for necropsy. The uteri of all pregnant animals contained late-term twin fetuses. The most prominent lesion was extensive fatty infiltration of the liver Massive lipidosis and lipid vacuoles were seen in sections of the livers. In three brains, there was prominent vacuolation in the white matter Urine analysis revealed ketonuria in most of the suspected sheep from the same flock. Serum glucose, cholesterol, high density lipoprotein cholesterol, and blood urea nitrogen concentrations were lower (pless than or equal to0.05) and serum triglycerides, aspartate aminotransferase and alanine aminotransferase activities were higher (pless than or equal to0.05) in these sheep than in the controls. After a change of diet and treatment, with glucose and dexamethasone serum glucose levels significantly increased (pless than or equal to0.001) and urine ketone bodies decreased but the other biocemical differences remained.Öğe Relationship between food sensitization and serum leptin levels with local airway inflammation in allergic rhinitis(Wiley-Blackwell, 2015) Kalpaklioglu, A. F.; Baccioglu, A.; Yildirim, E.; Kisa, U.…Öğe The effect of initial periodontal treatment on gingival crevicular fluid galectin-3 levels in participants with periodontal disease(Wiley, 2021) Karsiyaka Hendek, M.; Olgun, E.; Kisa, U.Background: The aim of study was to evaluate galectin-3 levels in gingival crevicular fluid (GCF) from periodontally healthy (H) patients and those with periodontitis (P), gingivitis (G) and the effect of initial periodontal treatment on GCF galectin-3 level. Methods: A total of 75 participants, 25 patients with periodontitis, 25 with gingivitis and 25 periodontally healthy subjects were included into the study. Patients with periodontal disease received initial periodontal treatment. GCF galectin-3 level was assessed at baseline and at the 6th-8th weeks after completion of periodontal treatment. GCF galectin-3 level was evaluated by enzyme-linked immunosorbent assay. Results: GCF galectin-3 level was the lowest in the H group (102.31[63.07] mu g/30 s), followed by the G group (241.45[145.89] mu g/30 s) and the highest in the P group (338.27[219.37] mu g/30 s). These differences were statistically significant between H and the other groups (P < 0.001). After initial periodontal treatment, GCF galectin-3 level significantly decreased in the G and P groups compared to baseline values (P < 0.01). Conclusion: The results of this study suggest that GCF galectin-3 level is a potential biomarker for the evaluation of gingival inflammation and initial periodontal treatment is effective in decreasing GCF galectin-3 level.
