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    Ghrelin and orexin levels in infertile male: Evaluation of effects on varicocele pathophysiology, relationship seminal and hormonal parameter
    (De Gruyter Open Ltd, 2020) Kisa Ü.; Murad Basar M.; Sipal T.; Ceylan Ö.D.
    Objective: The aim of the present study was to investigate serum ghrelin and orexin levels in patients with varicocele and compare these levels with idiopathic infertile male and healthy control cases. Methods: This study enrolled 24 men with varicocele, 24 males having idiopathic infertility, and 21 fertile men as the control group. Hormonal analyses, ghrelin and orexin levels were measured samples. Semen was analyzed after 3 and 5 days of sexual abstinence. Results: Serum ghrelin levels were statistically different among the three groups (p=0.015), and it was due to a statistically lower level in group-1 than the level in the control cases (p=0.012). On the other hand, serum orexin levels were lower than healthy subjects in infertile groups with/without varicocele, but there was no difference (p=0.685) among three groups. Serum ghrelin level showed a negative and significant correlation only with sperm motility (r=-0.646, p=0.022), there was no correlation with other parameters. On the other hand, serum orexin levels did not show a significant correlation with seminal parameters. Conclusion: Both new investigated peptides ghrelin and orexin have regulatory effects on testicular function. However, ghrelin has a more obvious and complex effect on spermatogenesis. Impaired seminal parameters, especially motility was associated with increased serum ghrelin levels in infertile patients, especially with varicocele. © 2020 De Gruyter. All rights reserved.
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    Quercetin, a powerful antioxidant bioflavonoid, attenuates renal dysfunction in long-term experimental diabetes mellitus
    (2011) Edremitlioğlu M.; Andiç M.F.; Sayin D.B.; Korkut O.; Kisa Ü.
    Objectives: Diabetes mellitus (DM) can cause serious complications such as nephropathy in long term. One of the factors of diabetic nephropathy pathogenesis is the increase of oxidant stress. The aim of this study is to examine the effect of quercetin, a powerful antioxidant agent, on renal functions in streptozotocin-induced diabetes mellitus and the change in balance of oxidantantioxidant capacity in this process. Methods: Five groups of rats were used: Control, DM 8 and 16-week (DM8, DM16), DM 8 and 16-week + quercetin (QUER8, QUER16). Rats in QUER8 and QUER16 were treated with IP quercetin (15 mg/kg/day) until the end of the experiment. Results: Malondialdehyte increased in the DM8 and DM16 groups. On the contrary, it decreased in the groups which were given quercetin. Accordingly, increase in NADPH oxidase activity, and decrease in superoxide dismutase and catalase activities in diabetic rats were determined. In the QUER8 and QUER16 groups, NADPH oxidase activity decreased while antioxidant enzyme activities increased. Functional kidney parameters were considerably corrupted in the diabetic rats. Sodium and water excretion via urine and plasma creatinine level in the QUER16 group were lower than in the DM16 group. Conclusion: These findings suggest that the administration of quercetin attenuated renal dysfunction and totally prevented the increase of kidney oxidant damage in DM.