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Öğe A comparison of four intravenous sedation techniques and Bispectral Index monitoring in sinonasal surgery(Australian Soc Anaesthetists, 2003) Büyükkoçak, Ü.; Özcan, S.; Daphan, C.; Apan, A.; Koc, C.This study was performed to investigate the quality of different intravenous sedation techniques, and the correlation between the Bispectral Index (BIS) values and the Observer's Assessment of Alertness/Sedation (OAA/S) scores. Eighty patients undergoing sinonasal surgery were randomly assigned to one of four groups. Group MF received midazolam and fentanyl, group PF received propofol and fentanyl, group MR received midazolam and remifentanil, and group PR received propofol and remifentanil. Heart rate and mean arterial pressuure values were not different among the groups. SpO(2) decreased only after intravenous medication in groups MF and MR (P<0.017). Emesis was less common with propofol. A positive relationship existed between the BIS values and OAA/S scores during the operation in all groups and the strongest correlation was observed in group PR (r=0.565 and P<0.001). In conclusion, these four intravenous sedation techniques did not change mean arterial pressure, heart rate or SpO(2) clinically and produced a similar level of light sedation. The BIS was useful for monitoring of sedation during sinonasal surgery under local anaesthesia with intravenous sedation.Öğe The effects of ropivacaine infiltration on post-tonsillectomy pain(Lippincott Williams & Wilkins, 2004) Arykan, O.; Ozcan, S.; Koc, C.; Akpynar, S.…Öğe Localization of T cells and subtypes in the paranasal sinus and turbinate mucosa in patients with chronic sinusitis(B C Decker Inc, 2004) Muluk, N.B.; Koc, C.; Atasoy, P.The aim of this study was to quantitate total T lymphocytes (total CD3+ cells) and T-lymphocyte subtypes (CD4+ [T helper] and CD8+ [T suppressor] cells) in patients with chronic sinusitis, who were treated with functional endoscopic sinus surgery (FESS) and to investigate the pathophysiology of persistent inflammation in chronic sinusitis. This prospective study was conducted in study and control groups. The study group consisted of 32 patients (20 male, 12 female) with chronic sinusitis who underwent FESS. The control group consisted of 8 nonsinusitis patients (5 male, 3 female) who underwent septoplasty. Specimens from the study group were excised from five regions: the uncinate process, maxillary and ethmoid sinuses, and middle and inferior turbinates. The specimens were examined with x10 magnification by light microscopy, and the slides with a severe inflammatory process were included. Punch biopsy of the control group was taken from the inferior turbinate with patients' written approval. The surgical specimens from the study and control groups were examined with an immunohistochemical staining technique with monoclonal antibodies against CD3, CD4, and CD8 surface antigens of T lymphocytes. In every specimen, the numbers of CD3+, CD4+, and CD8+ cells were-calculated in 3 to 4 high magnification field on light microscopy, and the mean number of these cells in the epithelium, subepithelial layer of the lamina propria, and deep paraglandular layer of the mucosa was determined. Statistical analysis by Kruskal-Wallis analysis of variance and the Mann-Whitney U test with Bonferroni correction revealed that the CD3 epithelial layer value of the inferior turbinate (p = .030) and the CD4 deep layer value of the middle turbinate (p = .048) were significantly higher than the corresponding values of the control group. In the epithelial (p = .018) and subepithelial (p = .012) layers of the uncinate process group, in the epithelial (p = .050) and subepithelial (p = .012) layers of the ethmoid sinus group, and in the subepithelial (p = .018) and deep paraglandular (p = .012) layers of the middle, turbinate group, the difference between the CD4+ and CD8+ cell counts was found to be statistically significant by the Wilcoxon signed rank test. The number of CD4+ cells was higher than the number of CD8+ cells. In conclusion, T cells play a role in the pathophysiology of chronic sinusitis. CD4+ T helper cells, in particular, are predominant at the initiation and regulation of inflammation. The uncinate process, ethmoid sinus, and middle and inferior turbinates have the main roles by T cells and subtypes in the defense system in chronic sinusitis.Öğe Minnesota Multiphasic Personality Inventory Profile of patients with allergic rhinitis(B C Decker Inc, 2003) Muluk, N.B.; Oguzturk, O.; Koc, C.; Ekici, A.The aim of this study was to investigate the relationship between allergic rhinitis and personality traits in a nonpsychiatric population of proven allergic status. Subjects were assigned to the allergic group (n = 29) and the nonallergic group (n = 29) on the basis of the medical examination, allergic prick tests, and self-reported allergic status. Analysis of Minnesota Multiphasic Personality Inventory Profile (MMPI) profiles showed that male subjects with allergic rhinitis had significantly higher scores on depression, paranoia, and social introversion. Depression, hypochondriasis, and hysteria scores were significantly higher in female subjects. It may be concluded that patients with allergic rhinitis have poorer psychological function compared with the nonallergic subjects.
