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Öğe A Case of Brucellosis Presenting With Widespread Maculopapular Rash(Lippincott Williams & Wilkins, 2009) Ayaslioglu, Ergin; Kocak, Mukadder; Bozdogan, OnderHuman brucellosis is a multisystemic infectious disease with a broad spectrum of clinical manifestations. Severe complications involving musculoskeletal, nervous, genitourinary, and cardiovascular systems may be encountered during the course of the disease; however, cutaneous complications have been reported rarely. We report a patient with brucellosis in whom the main presenting clinical feature was a maculopapular rash and fever. He was initially diagnosed as brucellosis based on the standard tube agglutination test and blood culture positivity. Histopathologic examination of these maculopapular lesions showed perivascular and periadnexal inflammation with loose granuloma formation including giant cells. We emphasize that brucellosis is an infectious disease that should always be kept in mind in the differential diagnosis of a patient with rash and fever, especially in endemic areas.Öğe Increased tumor necrosis factor alpha (TNF-α) and interleukin 1 alpha (IL1-α) levels in the lesional skin of patients with nonsegmental vitiligo(Blackwell Publishing, 2006) Birol, Ahu; Kisa, Ucler; Kurtipek, Gulcan Saylam; Kara, Fatma; Kocak, Mukadder; Erkek, Emel; Caglayan, Osman…Öğe Is it Subungual Melanoma? Fungal Melanonychia due to Phoma Glomerata(Cukurova Univ, Fac Medicine, 2015) Sari, Elif; Iseri, Latife; Kocak, Mukadder; Yildiz, DilaraA 32-years-old female patient referred to our clinic with melanotic color change at her right thumb nail. It was suspected from subungual melanoma. Therefore a full thickness biopsy and an excavation example was taken from the nail for the histologic and microbiologic examination. The lesion was reported as fungal melanonychia which was occured by Phoma Glomerata. As far as we know this is the first case that occured by Phoma Glomerata. Also the case could be misdiagnosed as subungual melanoma. Therefore we aimed to share this case with our colleagues.Öğe Markers of Endothelial Dysfunction and Evaluation of Vascular Reactivity Tests in Behcet Disease(Sage Publications Inc, 2014) Ozuguz, Pinar; Karabulut, Ayse Anil; Tulmac, Murat; Kisa, Ucler; Kocak, Mukadder; Gunduz, OzgurWe assessed endothelial dysfunction (ED) in patients with Behcet disease (BD; n = 40) and healthy controls (n= 20). Serum lipid, homocysteine, asymmetric dimethylarginine (ADMA) and high-sensitivity C-reactive protein (hsCRP) levels, erythrocyte sedimentation rates (ESRs), and ultrasonographic flow-mediated dilatation (FMD) were measured. Mean hsCRP, ESR, homocysteine, and ADMA were significantly higher in the BD group (P <.001 for all). Patients with active BD had higher serum levels of hsCRP, homocysteine, and ESR compared with those in remission (P <.001, P <.001, and P =.005, respectively). Flow-mediated dilatation was significantly lower in patients with BD than in controls (P =.001). Flow-mediated dilatation correlated negatively with BD duration and serum ADMA levels (P <.001, r =-.745 and P <.001, r = -.682); a positive correlation was seen between serum ADMA levels and BD duration (P <.001, r =.552). Only stepwise multivariate regression analysis revealed BD duration to have a significant effect on FMD. Flow-mediated dilatation, in conjunction with markers of inflammation, may evaluate ED in patients with BD.Öğe PCR investigation of Panton-Valentine leukocidin, enterotoxin, exfoliative toxin, and agr genes in Staphylococcus aureus strains isolated from psoriasis patients(Tubitak Scientific & Technical Research Council Turkey, 2015) Gocmen, Julide Sedef; Sahiner, Neriman; Kocak, Mukadder; Karahan, Zeynep CerenBackground/aim: Staphylococcus aureus colonization is a determiner of disease activation in psoriasis patients. Here we evaluate the presence of genes encoding Panton-Valentine leukocidin (PVL), enterotoxins, TSST-1, exfoliative toxins, and the accessory gene regulatory locus by polymerase chain reaction (PCR) in S. aureus isolates obtained from healthy and diseased skin regions and anterior nares of psoriasis patients and healthy controls. Materials and methods: The presence of PVL and toxin genes was investigated, and agr typing was performed by PCR. Results: Eighteen of the isolated strains carried the sei, 1 carried the seb-sec, and 1 carried the seg enterotoxin gene. Eight of the strains carrying enterotoxin genes were isolated from nasal swabs, 6 from diseased skin swabs, and 4 from healthy skin swabs. None of the strains isolated from the control group carried the agr locus. On the other hand, 11 of the S. aureus strains isolated from the patients carried type 1, 7 carried type 1 + 3, 4 carried type 2, 4 carried type 3, and 1 carried type 1 + 2 agr loci. Conclusion: Enterotoxin production and the carried accessory gene regulatory locus may be important in the aggravation of psoriasis.Öğe Scleredema Diabeticorum in a Patient with Type 2 Diabetes Mellitus(Galenos Yayincilik, 2016) Sari, Isilay Kalan; Durmaz, Senay Arikan; Bozdogan, Onder; Kocak, MukadderScleredema is a rare skin disease and clinically presents as diffuse, painless induration and thickening of the skin. Scleredema diabeticorum is usually slowly progressive and characterized by insidious onset and tends to be persistent. This type of scleredema primarily affects middle-aged and obese adults. Typically, affected area is the upper part of the body including the posterior neck, interscapular region and the chest. It usually develops in subjects with diabetes mellitus of long duration and poor metabolic control. We discussed a case of scleredema in a 54-year-old woman with a history of diabetes mellitus.Öğe Tangier disease in a Turkish family(Wiley-Blackwell, 2014) Sahiner, Neriman; Kocak, Mukadder; Demirceken, Fulya; Kisa, Ucler; Ayva, Sebnem; Kazkayasi, MustafaIn this report we describe the upper gastrointestinal tractus involvement in a rare genetic disease of lipid metabolism. A 12-year-old boy presented with sore throat and fever. On physical examination, orange-yellow tonsils and adenoid tissue were noted. Mild hepatosplenomegaly was present. Lipid profile was compatible with Tangier disease (TD). Endoscopy of the upper gastrointestinal tract showed white-yellowish fatty deposits on the gastric mucosa. Microscopically, biopsy specimens contained numerous histiocytes with a foamy cytoplasm packed in the lamina propria of the gastric mucosa and at the crypt basement of the duodenum. His sister, 8 years old, was also diagnosed with TD based on abnormal lipid profile and orange-yellow tonsils. TD is a rare familial disorder of lipid metabolism, characterized by deposition of cholesteryl esters, probably involving the entirety of the gastrointestinal tract from the mouth to the anus.
