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Öğe The effect of extracorporeal shock wave treatment (ESWT) on bone defects: An experimental study(1999) Uslu, Murad M.; Bozdoğan, Önder; Güney, S.; Bilgili, Hasan; Kaya, Ü.; Olcay, B.; Korkusuz, FezaThe aim of this study was to investigate the effects of extracorporeal shock wave therapy (ESWT) on the formation of callus in bone defects created in rabbit radii. This study searches for an answer to whether ESWT may have a therapeutic effect on bone defects. A bone defect with a radius of 1 cm was created in both forelimbs of 20 rabbits. At the 7th, 14th, and 21st days ESWT treatment was applied to the forming callus in the right radius under fluoroscopic control. At the 6th and 12th weeks, the animals were sacrificed and callus analysis was performed by computerized scan, dual energy x-ray absorptiometer. Histological analyses were also performed. The results revealed that the average callus area in the right (ESWT applied) radial defect was greater in both groups and statistically significant at the 12th week (p < 0.05). There was no difference in bone density between defects. Histologically the callus area was greater on the right side (ESWT applied side) in both groups. However in the first group trabeculae were occupying less space on the right side. Granulation tissue areas and chondroid areas were greater on the right side. We conclude that ESWT has a disorganizing and dispersing rather than a direct osteoinductive effect on forming callus. This effect may play a therapeutic role in bone defects and in situations like callus lengthening where a greater amount of callus is necessary.Öğe The Effects of Rhythm Training on Tennis Performance(De Gruyter Poland Sp Zoo, 2012) Söğüt, Mustafa; Kirazcı, Sadettin; Korkusuz, FezaRhythm training is an integral part of sports. The purposes of the study were to analyze the effects of rhythm training on tennis performance and rhytmic competence of tennis players, to compare the improvement levels of tennis specific and general rhythm training and to examine the effects of shorter and longer tempos on rhythmic competence. Thirty university students whose mean score of International Tennis Number (ITN) was 7.3 (+/- 0.9) were divided randomly into three sub-groups: Tennis Group, General Rhythm Training Group and Tennis-Specific Rhythm Training Group. The experimental procedure lasted 8 weeks. During this period, all groups had the same tennis training twice a week. The Tennis Group had regular tennis training sessions. In addition to regular tennis training sessions, the General Rhythm Training Group followed the general rhythm training sessions and the Tennis-Specific Rhythm Training Group had tennis-specific rhythm training. The measurement instruments were ITN, Rhythmic Competence Analysis Test and Untimed Consecutive Rally Test. The results indicated that participation in tennis-specific or general rhythm training resulted in progress in tennis playing levels, forehand consistency performance and rhythmic competence of the participants. On the other hand, attendance to the regular 8-week tennis training was enough to solely increase the tennis playing level but not sufficient to develop forehand consistency performance and rhythmic competence. Although the participants in the TRTG had better improvement scores than the ones in the GRTG, no significant difference was found between the rhythm training groups. The results also revealed that participants exhibited higher rhythmic competence scores on fast tempo compared to slow tempo.Öğe The future of treatment for chondral and osteochondral lesions(2007) Cırpar, Meriç; Korkusuz, FezaThe population of patients with symptomatic focal or generalized cartilage lesions is growing due to prolongation of life expectancy and to increasing frequency of sports injuries. Cartilage tissue lesions which were defined as untreatable in the past have now become treatable thanks to advances in basic scientific research. With the development of technologies regarding biomaterial, cell and local regulators, and with the introduction of new surgical techniques, it is estimated that, in the near future, clinical applications of cartilage tissue engineering will also receive particular attention in our country. Currently, all alternatives used in the treatment of cartilage lesions have merits and demerits, including arthroscopic debridement and lavage, mesenchymal stem cell stimulation, osteochondral replacement techniques, and autologous chondrocyte transplantation. Preliminary results of experimental cartilage tissue engineering are encouraging for the replacement of disrupted tissue with that having mechanical properties of hyaline cartilage. Clinical applications of cartilage tissue engineering include bioabsorbable scaffolds as extracellular collagen, hyaluronic acid matrices, and genetically engineered bioactive materials.Öğe Histological alterations after irradiation of cartilage using Ho: YAG laser(Mary Ann Liebert Inc Publ, 2003) Atik, OS; Erdoğan, Deniz; Ömeroğlu, Suna; Korkusuz, Feza; Uslu, Murad M.; Eksioglu, FatihThe authors carried out an experimental study to evaluate the histological alterations after irradiation of cartilage using Holmium:YAG (Ho:YAG) laser VersaPulse Select 60 watts and Infra. Tome Delivery Systems 30degrees Handpiece (spot size at fiber tip 0.4 mm; Coherent Medical, Palo Alto, CA). Background Data: Recently, some authors reported cases with articular cartilage damage following arthroscopic laser surgery in the knee joint for the treatment of articular cartilage or meniscal pathology. Materials and Methods: The cartilage specimens immersed in saline were exposed to Ho:YAG laser irradiation. The laser wavelength was 2.1 mum, and pulse duration was 250 musec. Power settings were 0.2-1 joules per pulse and 10-15 Hz. Total laser energy used in these procedures was 1.5 K joules. During the procedures, the handpiece was used at an angle of 30degrees and at a distance of 1 mm. Results: Electron microscopic evaluation demonstrated that the ultrastructure of the cartilage is preserved in both experiment and control groups. Conclusion: When Ho:YAG laser is used in optimal dosage (optimal joule and Hertz) with optimal technique (keeping the handpiece at an appropriate angle and distance) and avoiding overtreatment, it does not cause cartilage damage.Öğe In vivo human brain biochemistry after aerobic exercise: preliminary report on functional magnetic resonance spectroscopy(Elsevier Science Inc, 2005) Çağlar, Ertunga; Sabuncuoğlu, Hakan; Keskin, Tülay; Işıklı, Sedat; Keskil, Semih; Korkusuz, FezaBackground: Our aim was to disclose whether the positive psychological changes observed after a single bout of aerobic exercise have a biochemical correlate that can be visualized by proton magnetic resonance spectroscopy (MRS) of the human brain. Methods: Right-handed male volunteers underwent psychological testing and MRS of the frontal lobe of the left hemisphere, both before and after 20 minutes of jogging at about 70% of their maximal aerobic capacity. Results: Although there was a significant decrease on the postexercise anxiety test scores (z = -2.201, P <.05), there was no significant difference between the preexercise and postexercise scores of positive and negative affect. Considering both "amplitude" and "area under the curve" values calculated for the peaks of metabolites N-acetylaspartate (NAA), creatine, and choline, none were found to be significantly changed (P >.05) after the exercise. Conclusion: This is, to our knowledge, the first study to report on a functional application of MRS to mood states. Because it offers the ability to directly measure metabolic changes in the brain during neuronal activation, "functional MRS" may be a potential new tool that may be used as an adjunct to functional magnetic resonance imaging. (c) 2005 Elsevier Inc. All rights reserved.Öğe Joint angles during successful and unsuccessful tennis serves kinematics of tennis serve(Turkish Joint Diseases Foundation, 2009) Goktepe, Ayhan; Ak, Emre; Sogut, Mustafa; Karabork, Hakan; Korkusuz, FezaObjectives: The aim of this study was to investigate the joint angle differences in successful and unsuccessful tennis serves of junior tennis players. Patients and methods: Nine healthy junior tennis players (5 girls, 4 boys; mean age 11.8 +/- 0.8 years; height 153.6 +/- 7.2 cm; body mass index 42.3 +/- 4.1 kg; playing experience 6.2 +/- 1.5 years) volunteered to participate in this study. They were asked to perform tennis serves as fast as they can as if they were in an actual game. Successful and unsuccessful serves were recorded using two high speed cameras and then analyzed using Pictran software. Angle changes in pre-impact, impact and post-impact phases were compared. Results: The results of paired sample t-tests revealed nosignificant differences between successful and unsuccessful tennis serves in all three phases. Conclusion: This study failed to show differences between successful and unsuccessful tennis serves in pre-impact, impact and post-impact phases. However, future research with more detailed analyses would be needed to reveal the possible changes in the joints while serving.Öğe Segmenter kemik defektlerinde şok dalgalarının etkisi: Tavşan radiusunda deneysel çalışma(1999) Uslu, M. Murad; Bozdoğan, Önder; Güney, Şefik; Korkusuz, Feza; Bilgili, Hasan; Kaya, Ümit; Olcay, BurhanettinBu çalışmanın amacı şok dalgalarının (SD) tavşan radiustında oluşturulan kemik defektlerinde oluşan kalkışa etkilerinin araştırılmasıdır. Bu çalışmada şok dalgalarının kemik defektlerine tedavi edici bir etkisinin olup olamıyacağı sorusuna bir cevap aranmaktadır. Yirmi adet Yeni Zelanda tavşanının lıeriki radiıısunda 10 milimetrelik birer defekt oluşturuldu. 7., 14. ve 21 günlerde floroskopik kontrol altında sağ taraftaki defektlere şok dalgaları uygulandı. Altıncı ve onikinci haftalarda tavşanların her iki radi ustaki defektlerine bilgisayarlı tomografi, ve dual enerji X-ray absorbsiometresi (DEXA) kullanarak kallus analizi gerçekleştirildi. Histolojik analiz yapıldı. Sonuç olarak her iki grupta da, şok dalgaları uygulanan sağ taraftaki defektde kalkış alanı, uygulanmayan tarafa göre daha büyük bulundu. Bu fark onikinci haftada istatiksel olarak anlamlı idi (p<005). Kemik yoğunluğu ölçümleri arasında anlamlı fark yoktu. Histolojik olarak sağ tarafta kallus alanı daha genişdi. Trabekuler yapı daha az alan kaplıyordu, granulasyon dokuları ve kondroid alanlar sağ tarafta daha yoğun izleniyordu. Son yıllarda pseudoartroz tedavisinde başarılı klinik sonuçlar yayınlanan şok dalgalarının osteoindüktif etkisi tartışmalıdır. Bu çalışmada izlenen etki, oluşmakta olan kalkıştı dağıtıcı ve yayıcı bir etkidir. Bu çalışma ışığında şok dalgalarının callus uzatma ameliyatları, kemik defektleri gibi kallus hacmında artışa ihtiyaç duyulan dururmlarda kullanılması gündeme gelebilir.Öğe Skeletal muscle fatigue does not affect shooting accuracy of handball players(Ios Press, 2019) Akyuz, Beyza; Avsar, Pinar Arpinar; Bilge, Murat; Deliceoglu, Gokhan; Korkusuz, FezaBACKGROUND: Shooting accuracy and ball speed are important factors relating to scoring in handball that could be affected by skeletal muscle fatigue. OBJECTIVE: To explore the effects of muscle fatigue on male handball players' shooting accuracy and ball speed. METHODS: Sixteen elite handball players (M-age = 17.1 +/- 1.7 years) participated in the laboratory and the field-testing sessions. Running speeds equal to 75% of participants' maximal oxygen uptake (VO2max) values from laboratory tests were used as the initial velocity for the 30-15 intermittent fitness test (30-15(IFT)) in the fatigue protocol. Participants shot to the target at random visual signals placed behind the target before and after fatigue. In order to measure wrist acceleration and ball speed, an accelerometer and a radar gun are used respectively and numbers of accurate and inaccurate shots also recorded. RESULTS: There were no significant differences between pre-fatigue and post-fatigue protocols in terms of accurate and inaccurate shots, and ball speed. Only wrist acceleration in the Y axis (M-pre(-fatigue) = 33.12, SD = 1.17msec; M-post - fatigue = 34.50, SD = 1.21msec) was affected by the fatigue protocol in inaccurate shots (p = 0.042). CONCLUSIONS: Muscular fatigue does not affect shooting accuracy and ball speed in male handball players.Öğe Zor kaynayan kemik kırıklarının tedavisine yönelik kemik morfojenik proteini içeren biyobozunur polimerik salım sistemleri tasarlanması(2003) Hasırcı, Vasıf; Korkusuz, Feza; Tezcaner, Ayşen; Keskin, Esra DilekKemik morfojenetik proteinler (KMP) kemik oluşumunu uyarıcı özellikleri nedeniyle çeşitli kemik hastalıkları üzerinde klinik araştırmaları yoğun bir şekilde sürmekte olan proteinlerdir. Kemik oluşumundaki güçlü etkileri nedeniyle tedavide lokal olarak sadece hasarlı kemik bölgesine uygulanmaları gerekmektedir. Bu amaçla son yıllarda KMP içeren değişik birçok polimer ilaç salım sistemi araştırılmıştır. Bu klinik ihtiyacı düşünerek KMP yüklü disk şeklinde çözülebilir Kollajen ve kondroitin sülfat içeren taşıyıcı bir sistem tasarlanmıştır. İn situ salım deneyleri model olarak seçilen bir protein (floresan işaretli protein A) ile yapılmış ve bunların sonucunda çok yüksek salım hızı (hemen hemen bütün malzemenin 24 saatte salındığı) gözlenmiştir. Çözünebilir kollajenin yüksek su bağlanma kapasitesiyle açıklanabilen bu problem sistemin poli(L-laktit), (PLLA) ve sükroz asetat izobutirat (SAIB) polimerlerinin karışımıyla kaplanması ile çözülmüştür. Böylece model ilaç için salım süresi 12 güne uzatılabilmiştir. Aynı sistemin KMP ile yapılan in situ salım deneyleri KMP ye özel ELISA kitleri ile yapılmış ve model ilaçtan daha yavaş salım ele edilmiştir. KMP sahraları ilacın yarısının 15 günde salındığını göstermiştir. Osteoblast hücreleri ile yapılan in vitro deneylerde 2 $\\mu$g KMP içeren impantların ALP enzim aktivitesinde anlamlı farklılıklar bulunmuştur. KMP salım sistemini in vivo uygulamalar sırasında kemikte hasarlı bölgede sabit tutabilmek ve aynı zamanda kemiğe de destek sağlamak amacıyla, Vicryl ameliyat ipliklerinin örülüp, daha sonra poli(L-laktit-ko-glikolit) (PLGA) ile fiber bağlanma yöntemi ile bağlanması ile bir ağ yapı hazırlanmıştır. Bu ağ yapı ile Kemikteki iyileşme düzeyi iki zaman süreci (1 hafta ve 3 hafta) için değerlendirilmiştir. KMP taşıyıcı sistemin kemik oluşumunu indükleyici (osteoinductive) etkisi histolojik skorlama, x-ışınları (röntgen analizleri) ile değerlendirilmiştir. İn vitro deneyler KMP yüklü PLLA-SAIB kaplanmış kollajen, kondroitin sülfat disklerinin iyi biyouyumluluk ve optimum osteojenik uyarıcı etkisi olduğunu göstermiştir. Histoloji mikrograflarındaki l hafta sonundaki yapısal değişiklikler doza bağlı periostta kemikleşme göstermektedir. 3 hafta sonundaki histolojik bulgularda ise her iki dozda da (1 ve 2$\\mu$ g) sonuçlar yaklaşık aynıdır.
