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Öğe Apoptosis in testicular tissue of rats after vasectomy: Evaluation of eNOS, iNOS immunoreactivities and the effects of ozone therapy(AVES Ibrahim Kara, 2014) Alpcan S.; Başar H.; Aydos T.R.; Kul O.; Kısa Ü.; Başar M.M.Objective: We aimed to investigate the changes in endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) expression and apoptotic index in rat testicular tissue, as well as serum and seminal plasma sex hormone levels after vasectomy, and the effect of ozone therapy (OT).Material and methods: Adult male Wistar rats were used (n=6 per group). Control (G1), sham for 4 weeks (G2) or 6 weeks (G3), orchiectomy at the 4th (G4) or 6th (G5) week after left vasectomy, orchiectomy at the 4th (G6) or 6th (G7) week after bilateral vasectomy, orchiectomy after 6 weeks OT following left (G8) or bilateral (G9) vasectomy, orchiectomy after 6 weeks OT (G10).Results: In the left testes, while there were increases in eNOS and iNOS immunoreactivity and apoptotic indexes in G4 and G5, no changes were observed in contralateral testis. These values increased in G6 and G7, while OT inhibited these parameters in the left testis of G8 and both testes of G9. Sex hormone levels did not show any changes after vasectomy and ozone therapy.Conclusion: While OT was found to be protective against some parameters mentioned above under stress conditions, it seemed to cause some harmful effects when used in healthy conditions. © 2014 by Turkish Association of Urology.Öğe Examination of epithelial tissue cytokine response to natural peste des petits ruminants virus (PPRV) infection in sheep and goats by immunohistochemistry(2012) Atmaca H.T.; Kul O.In this study, we aimed to evaluate expression of IL-4, IL-10, TNF-?, IFN-? and iNOS in lingual, buccal mucosa and lung epithelial tissue using immunoperoxidase technique and to compare with the tissues of control animals. The tissues used in the study were collected from 17 PPRV-affected and 5 healthy sheep and goats. In PPRV positive animals, the lungs, lingual and buccal mucosa had significantly higher iNOS, IFN-? and TNF-? expressions compared to control group animals. There was no significant difference between PPRV positive and control groups for IL-4 and IL-10 expressions of epithelial tissues. In conclusion, the epithelial tissues infected by PPRV showed significant iNOS, IFN-? and TNF-? expressions and they might play an important role in the initiation and regulation of cytokine response, as they take place in the first host barrier to be in contact with PPRV. It is suggested that the more epithelial damage produced by PPRV the more cytokine response may result in the infected epithelial cells. The first demonstration of iNOS expression and epithelial cytokine response to PPRV in natural cases is important because it may contribute to an early initiation of systemic immunity against PPRV infection, in addition to direct elimination of the virus during the initial epithelial phase of the infection.Öğe Modification of animal products for fat and other characteristics(Springer Berlin Heidelberg, 2015) Saeed A.; Abubakar M.; Kul O.This chapter includes information about modification of animal products using biotechnology and the importance of different modifications on the natural composition. The species considered for modified products include beef and dairy cattle, sheep, goats, poultry, and a wide variety of fishes. Moreover, the discussion includes the importance of animal food, nongenetically engineered animal modified food products, genetically engineered animal modified food items primarily for meat, milk, or egg and genetically engineered animal food along the transgenic approach for animal welfare. Modern biotechnology can improve productivity, consistency, and quality of alter animal food, fiber, and medical products. The transgenic technology is potentially valuable to alter characters of economic importance in a rapid and precise way. The food safety issue related to genetic engineering is also included in this chapter. The harm of such modified food and transgenic strategy should also be understood by the reader along with its advantages. In this context, transgenic approaches in animal biotechnology are under discussion that ranges from animal food production to their adverse effects. © Springer-Verlag Berlin Heidelberg 2015.Öğe Pathology of peste des petits ruminants virus infection in small ruminants and concurrent infections(Springer Berlin Heidelberg, 2015) Kul O.; Atmaca H.T.; Munir M.Peste des petits ruminant (PPR) is a systemic viral disease of goats and sheep characterized by gastrointestinal and respiratory system lesions with high rate of mortality. Rhinitis, conjunctivitis, serous-mucopurulent naso-ocular discharge, pneumonia, coughing, dispnea, erosive-ulcerative oral lesions, and diarrhea are the most prominent clinicopathological features of the disease. Histopathologically, pseudomembraneous stomatitis, necrotic tonsillitis, fibrinohemorrhagic enteritis, and proliferative interstitial pneoumonia are seen. Syncytial cells and cytoplasmic and/or nuclear eosinophilic inclusion bodies are considered as pathognomonic. Like the other morbilli viruses, PPR virus can also cause lesions in the kidney, brain, and abomasum. The PPRV tropism can be explained by the mechanism in which PPRV binds to receptors on the cell surface. The PPR in small ruminants often shows coassociation with secondary viral, bacterial, and parasitary infections. © Springer-Verlag Berlin Heidelberg 2015.Öğe The role of biotechnology in improvement of livestock: Animal health and biotechnology(Springer Berlin Heidelberg, 2015) Abubakar M.; Saeed A.; Kul O.This book examines how biotechnology can improve livestock breeding and farming, and thereby also animal products. In the first chapters the reader will discover which techniques and approaches are currently used to improve animal breeding, animal health and the value of animal products. Particular attention is given to reproduction techniques, animal nutrition and livestock vaccines that not only enhance animal health but also have a significant effect on human health by ensuring safe food procurement and preventing zoonotic diseases. In addition, modern biotechnology can increase not only productivity but also the consistency and quality of animal food, fiber and medical products. In the second part of the book, issues such as how animal biotechnology could affect the environment and the important topic of animal waste management are explored. In the concluding chapter, the authors discuss future challenges related to animal biotechnology. This work will appeal to a wide readership, from scientists and professionals working in animal production, to those in farm animal management and veterinary science. © Springer-Verlag Berlin Heidelberg 2015.
