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  • Küçük Resim
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    Characterization of Leiurus abdullahbayrami (Scorpiones: Buthidae) venom: peptide profile, cytotoxicity and antimicrobial activity
    (Biomed Central Ltd, 2014) Erdes, Efe; Dogan, Tugba Somay; Cosar, Ilhan; Danisman, Tarik; Kunt, Kadir Bogac; Seker, Tamay; Ozen, Can
    Background: Scorpion venoms are rich bioactive peptide libraries that offer promising molecules that may lead to the discovery and development of new drugs. Leiurus abdullahbayrami produces one of the most potent venoms among Turkish scorpions that provokes severe symptoms in envenomated victims. Methods: In the present study, the peptide profile of the venom was investigated by electrophoretic methods, size-exclusion and reversed-phase chromatography and mass spectroscopy. Cytotoxic and antimicrobial effects were evaluated on a breast cancer cell line (MCF-7) and various bacterial and fungal species. Results: Proteins make up approximately half of the dry weight of L. abdullahbayrami crude venom. Microfluidic capillary electrophoresis indicated the presence of 6 to 7 kDa peptides and proved to be a highly practical peptidomics tool with better resolution when compared to conventional polyacrylamide gel electrophoresis. Mass spectroscopy analysis helped us to identify 45 unique peptide masses between 1 to 7 kDa with a bimodal mass distribution peaking between molecular weights of 1 to 2 kDa (29%) and 3 to 4 kDa (31%). L. abdullahbayrami crude venom had a proliferative effect on MCF-7 cells, which may be explained by the high concentration of polyamines as well as potassium and calcium ions in the arachnid venoms. Antimicrobial effect was stronger on gram-negative bacteria. Conclusions: This work represents the first peptidomic characterization of L. abdullahbayrami venom. Considering the molecular weight-function relationship of previously identified venom peptides, future bioactivity studies may lead to the discovery of novel potassium and chloride ion channel inhibitors as well as new antimicrobial peptides from L. abdullahbayrami venom.
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    DESCRIPTION OF THE HITHERTO UNKNOWN FEMALE OF PELECOPSIS TOPCUI (TURKES ET. AL. 2015), COMBN (ARANEAE, LINYPHIIDAE)
    (Amer Entomol Soc, 2020) Danisman, Tarik; Cosar, Ilhan; Ozkutuk, Recep Sulhi; Kunt, Kadir Bogac
    In this study, Abacoproeces topcui Turkes et. al. 2015 is shown to be an inappropriate generic assignment. The male and hitherto unknown female are redescribed and the species is transferred to Pelecopsis comb.n.
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    Three new Genus Records of the Spider Fauna of Turkey (Araneae: Salticidae)
    (Florida Entomological Soc, 2013) Cosar, Ilhan; Elverici, Mert; Danigman, Tarik; Kunt, Kadir Bogac
    New records of 3 genera and 3 species of Salticidae from Turkey are presented for Bianor albobimaculatus (Lucas, 1846), Dendryphantes rudis (Sundevall, 1833) and Hyllus insularis Metzner, 1999. Their morphology is briefly described and illustrated. Current knowledge on diversity of Salticidae in Turkey is also reviewed. Total number of Salticidae species recorded from Turkey now is 102.