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Öğe Can Ondansetron be an Alternative to Cabergoline for Preventing Ovarian Hyperstimulation Syndrome?(Aras Part Medical Int Press, 2023) Bakirci, Sukru; Kurdoglu, Mertihan; Khaki, Arash[Abstract No tAvailable]Öğe Can We Benefit From Ozone to Improve Female Reproductive Health?(Aras Part Medical Int Press, 2022) Kurdoglu, Mertihan[Abstract No tAvailable]Öğe Could maternal serum MFG-E8 level predict adverse fiirst trimester pregnancy outcome? A preliminary study(Tubitak Scientific & Technological Research Council Turkey, 2023) Elci, Bircan; Yalcinkaya, Zeynep; Tekin, Ercan; Bakirci, Sukru; Dayangan Sayan, Cemile; Kisa, Ucler; Kurdoglu, MertihanBackground/aim: Milk fat globule-epidermal growth factor 8 (MFG-E8) is expressed in the endometrial epithelium and its expression increases during the implantation process. Due to this knowledge, we aimed to investigate the maternal serum MFG-E8 levels on both healthy pregnant women in the first trimester and pregnant women complicated with missed abortion and threatened abortion in the first trimester.Materials and methods: This prospective, cross-sectional study was conducted in a tertiary referral hospital, department of obstetrics between July 2020 and February 2021 after ethical committee approval. The study population was consisted of 30 healthy pregnant women (HP) in the first trimester, 30 pregnant women suffering from threatened abortion (TA) in the first trimester and 30 pregnant women suffering from missed abortion (MA) in the first trimester. Maternal serum MFG-E8 levels were analyzed with enzyme linked immunosorbent assay. Delivery and neonatal outcomes of the study population was evaluated. The continuous variables were compared among three groups with variance analysis with post hoc tests. The categorical variables were compared with chi-square and Fisher's exact tests where applicable.Results: The mean age of the study population was 29.36 +/- 5.31 years. There was no significant difference among three groups for parameters of age, body mass index, parity number, and gestational week. Despite being within normal ranges, the mean neutrophil and international normalized ratio values of the three groups showed statistically significant difference (p < 0.05). The mean maternal serum MFG-E8 levels of MA, TA, and HP groups were 270 +/- 152.3, 414.7 +/- 236.7, and 474 +/- 222.5 ng/mL, respectively (p = 0.001). It was found that mean of MFG-E8 of the MA group was statistically significantly lower than those of the other two groups (p < 0.05).Conclusion: Although maternal serum MFG-E8 level seems to be a parameter that differ between live and nonlive pregnancies, studies with large number of cases are needed to discuss our results and to determine a cut-off value for predictionÖğe Diagnosing Polycystic Ovary Syndrome Using Triglyceride-Related Indices: Is It Possible Without Rotterdam Criteria?(Aras Part Medical Int Press, 2023) Keyif, Betul; Yavuzcan, Ali; Kurdoglu, Mertihan[Abstract No tAvailable]Öğe Do We Need Alternative Screening Approaches for Cervical Cancer During Covid-19 Pandemic?(Aras Part Medical Int Press, 2021) Kurdoglu, Mertihan; Khakiid, Arash[Abstract No tAvailable]Öğe Expression of laminin-1 and matrix metalloproteinase-9 in benign and malignant endometrium(Tubitak Scientific & Technological Research Council Turkey, 2023) Kucukaydin, Zehra; Basaran, Mustafa; Unlu, Yasar; Basaran, Ahmet; Kurdoglu, MertihanBackground/aim: Laminin-1 and matrix metalloproteinase (MMP)-9 may play roles in the progression from benign to malignant endometrium, so we aimed to investigate their levels of expression in these tissues.Materials and methods: This case-control study was conducted at a tertiary care center between January 2014 and December 2016. Paraffin blocks of 50 specimens of benign endometrium with proliferative (n = 20), secretory (n = 11), and atrophic (n = 5) endometrium; simple endometrial hyperplasia without atypia (n = 12); and endometrial polyp (n = 2) histology and 49 specimens of malignant endometrium with endometrioid (n = 40), serous (n = 7), clear cell (n = 1), and undifferentiated (n = 1) types were immunostained with laminin-1 and MMP-9 antibodies and assessed for basement membrane continuity for laminin-1 and the percentage and intensity of MMP-9 expression in epithelial cytoplasm.Results: Laminin-1 continuity in the basement membrane was higher in benign (92%) compared to malignant (16.3%) endometrium (p < 0.0001) without any difference between the subgroups within each group (p > 0.05). All atrophic endometria and endometrial polyps and 23.5% of low grade endometrioid and none of the other endometrial cancers showed uninterrupted basement membrane staining with laminin-1. All cases in malignant endometrium expressed MMP-9 with either low or high immunoreactivity while none of the cases in benign endometrium showed a high staining with MMP-9 (p < 0.01). Proliferative and hyperplastic endometrium together with grade 1 endometrioid cancer expressed MMP-9 better than the atrophic endometrium (p < 0.05). The immunoreactivity with MMP-9 increased gradually from secretory to hyperplastic endometrium and serous carcinoma (p < 0.05). MMP-9 expression in all types of cancers except grade 1 endometrioid and clear cell compared to proliferative endometrium was significantly higher (p < 0.05) and increased from proliferative to grade 2 endometrioid, grade 3 endometrioid, serous and undifferentiated endometrial carcinoma.Conclusion: Gradual increments in MMP-9 expression and basement membrane laminin-1 discontinuity may indicate progression from normal to hyperplastic and to low-and high-grade cancerous endometrium.Öğe Laminin Receptor 1: Can It Have a Role in Molecular Classification and Targeted Therapy of Endometrial Cancer?(Aras Part Medical Int Press, 2019) Kurdoglu, Mertihan…Öğe Obituary: Remembering Professor Oktay Kadayifci (1942-2015)(Aras Part Medical Int Press, 2019) Kurdoglu, Mertihan; Khaki, Arash…Öğe Postpartum Bleeding: What Are the Best Criteria for Diagnosis?(Aras Part Medical Int Press, 2023) Kurdoglu, Mertihan; Khaki, Arash[Abstract No tAvailable]Öğe Recurrent Implantation Failure: Is It Time to Redefine It?(Aras Part Medical Int Press, 2022) Kurdoglu, Mertihan[Abstract No tAvailable]Öğe The Nutritional Habits and Relationship Between The Antioxidant Activity and Iron Deficiency Anemia During Pregnancy(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Guven, Suzan; Meral, Ismail; Kurdoglu, Mertihan; Demir, HalitThe aim of this study was to investigate the changes in nutritional habits, and also relationship among oxidative stress, iron deficiency anemia and some antioxidant enzyme activities during pregnancy. Twenty pregnant women in the first trimester, 20 pregnant women in the last trimester and 20 non-pregnant women (control group) were included in the study. The study groups were similar in terms of age and body mass index. None of the participants had any systemic disease or smoked. After having filled out the questionnaire about nutritional habits, the blood samples were collected, and the malondialdehyde (MDA) level and activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) enzymes were measured together with hemoglobin (Hgb), hematocrit (Hct), iron, ferritin and the mean erythrocyte volume (MCV) levels. The most frequent meat consumption was on every other day in controls, but once a week in the first and last trimester groups. In addition, the most frequent egg consumption was on every other day and once a week in contro ls, but rare in the first trimester group, and once a week in the last trimester group. Although iron and vitamin use was 10% and 30% in the first trimester group, it was 50% and 65% respectively in the last trimester group. The MDA level was higher, and t he SOD, CAT and GSH-Px enzyme activities were lower in both pregnant groups than controls. The Hgb and Hct values were lower in the last trimester group compared to the controls and the first trimester group. The first trimester group and the controls were similar in terms of Hgb and Hct levels. There was no significant difference among groups in terms of ferritin, iron or MCV values. It was concluded that; a) the egg and meat consumption might decrease with the progress of pregnancy, b) the oxidative stress increased in pregnancy, c) Hgb and Hct values might be lower in the last trimester group despite increased intake of oral iron and vitamin supplements, and normal serum iron levels due to decreased CAT activity. Therefore, more studies are needed to demonstrate the relationship among oxidative stress, anemia and CAT enzyme activity in pregnancy. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Öğe What Is the Current State of Knowledge About the Novel Coronavirus Infection During Pregnancy?(Aras Part Medical Int Press, 2020) Kurdoglu, Mertihan; Khaki, Arash…
