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    Clinicopathological Evaluation of Clear Cell Hidradenoma (Acrospiroma) Within Multiple Tumor Complex in a Dog
    (Univ Fed Rio Grande Do Sul, 2018) Alcigir, Mehmet Eray; Kutlu, Tuncer; Ergin, Irem; Sonmez, Gonca
    Background: Clear cell hidradenoma (acrospiroma) is adnexal tumors that arise from the distal excretory duct of eccrine sweat glands. It is generally defined in humanbeings. It presents solitary structure in firmness nodule. Most frequently are encountered in head, face, and upper extremities in humans. Hidradenomas are called generally by definition benign. Their malignant transformations and metastasis are seen very rarely. In veterinary literature database, the malignant form of tumor has been defined as an unique report in four dogs. They are extremely rare tumors in dogs. It is not documented within multiple tumor complex up to now. Case: In the case, three tumors were detected in a 9-year-old neutered female German shepherd dog. After clinical examination, a complete surgical resection of all masses was performed and masses were sent to Pathology for diagnosis. A mass on the right last rib was a 8x6 cm in diameters with severe ulceration. The mass had a hard texture, immobility and irregular borders. Other masses were localized on the back and left caudo-abdominal manunary lobe. Tumors on the back and the mammary lobe did not invade muscle layer, but the tumor on the last rib aggressively invaded surrounding tissue and were very difficult to remove surgically After macroscopy, all the masses were stained with hematoxylin-eosin (I I&E), Mayer's mucicarmine and Periodic Acid Shiff (PAS) stainings. In the first mass, there were multilobular epithelial islands between prominent fibrous septa from the upper to deep of dermis. The neoplastic cells were generally round or polyhedral in shape. Some of cytoplasms were eosinophilic at different degree. But cytoplasms were generally finely granular and vesicular or clear in appearance. Some cells had possible glycogen deposits. Nucleus was oval to round and had fine reticular chromatin and a distinct nucleolus. The tumor was diagnosed as clear cell hidradenoma. Others were was belonged to hemangioma on the back and malignant mixed tumor in the mammary gland. Discussion: In our case, two cell types having benign characteristics were also noted. Some clear cells contained PAS (+) material showing glycogen deposits. Additionally, there were some fibrous septa separating those cell islands. Thus, it is thought that the histopathology shows parallelism to many reports described in human beigns. Clear cell hidradenoma described in this case is first documentation as benign counterpart on the basis of veterinary literatures even though a previous report including clear cell hidradenocarcinoma in four dogs. And also, it has been reported to be very rarely seen tumor in human beings. However, any hormonies in terms of its predilection site can not be found among the cases with clear cell hidradenoma in human counterparts, because the tumor is encountered at skin of last right rib. This situation has shown us the tumor does not select any predilection site as described in this case. It has been understood on the basis of literatures that this is the first case report of describing benign tumor of ecrine sweat duct in dogs. Also, there has been no any documentation regarding in this multiple tumor complex.
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    Öğe
    Desmoplastic Small Round-Cell Tumor in a Dog
    (2018) Alçığır, Mehmet Eray; Kutlu, Tuncer; Çolakoğlu, Ekrem Çağatay; Dinç, Ceyda
    A 13-year-old, neutered female Husky dog was brought to the clinic with the complaints of anorexia, vomiting, abdominal distension and respiratory distress. It was suddenly died during intervention. At the necropsy, a mass was seen in the abdominal cavity. The mass had 16x15x9 cm in diameters. Histological examination revealed clusters of cells with slightly eosinophilic and scanty cytoplasm, small round hyperchromatic nuclei, and inconspicuous nucleoli encompassed by hypocellular extensive desmoplastic connective tissue stroma comprising few spindle-shaped connective tissue cells. In immunohistochemical examination the cytoplasms of tumour cells were detected to be mildly positive by nestin. The tumour cells were negative for ?-SMA (Alpha-Smooth Muscle Actin), vimentin and pancytokeratin, but stromal cells were positive for ?-SMA and vimentin. Despite the presence of partially incompatible immunohistochemical findings, the tumor in this case was diagnosed as desmoplastic small round-cell tumor because its aggressiveness, localization, and histopathology was similar to that observed for this tumor in humans. Previously this tumor has not been identified in animals.
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    Effects of incubator oxygen and carbon dioxide concentrations on hatchability of fertile eggs, some blood parameters, and histopathological changes of broilers with different parental stock ages in high altitude
    (Elsevier, 2022) Okur, Nezih; Eratalar, Sabri Arda; Yigit, Ayse Arzu; Kutlu, Tuncer; Kabakci, Ruhi; Ozsoy, Sule Yurdagul
    The effects of incubator carbon dioxide (CO2) and oxygen (O-2) concentrations with parental stock age (PSA) on embryonic deaths (ED), hatchability of fertile eggs (HFE), some blood parameters, and the tissue development of broilers were investigated. Four consecutive repetitions following the similar materials and methods were carried. From 3 different aged ROSS 308 broiler parental flocks 7,680 hatching eggs were obtained and classified as young (Y; 29 wk), middle (M; 37 wk) and old (O; 55 wk) as regards PSA, and randomly distributed. Four different incubator ventilation programs (IVP) as control (C; 0.67% CO2 and 20.33% O-2), high CO2 (HC; 1.57% CO2 and 20.26% O-2), high O-2 (HO; 0.50% CO2 and 21.16% O-2), and high CO2 + O-2 (HCO; 1.17% CO2 21.03% O-2) were applied with oxygen concentrator, and ED and HFE were investigated. Lung and heart tissues, hemoglobin value, packed cell volume, and red blood cell count, triiodothyronine, thyroxine, adrenocorticotropic hormone (ACTH) values of the chicks were analyzed. It was found that IVP affected ED and HFE. Higher rate of early ED (EED) was obtained from the HC than HCO, and higher middle+late stage +pipped but unhatched ED (MLPED) with a lower rate of HFE was observed in the C group than HO and HCO (P < 0.05). Association was found between PSA and IVP (P < 0.05), being more evident in EED for young PSA, in MLPED with HFE for Y and O PSA. From hematological values, no statistical difference in RBC, PCV, and Hb values were found among the treatment groups, ACTH concentration known as a response to stress was found to be higher than C in all groups, triiodothyronine concentration was higher in the HO group than C. In the histopathological examination, used IVPs were found to have negative effects on the lung and heart such as vacuolization, hemorrhage in all PSA groups except for C. Conclusively, PSA and IVP affected some hatching, blood and tissue development parameters of the broiler chicks.