Yazar "Lale M." seçeneğine göre listele

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    Controlled release of Aldicarb from carboxymethylcellulese microcapsules
    (1997) Arica M.Y.; Yiğtoğlu M.; Lale M.; Kök F.N.; Hasirci V.
    Sodium carboxymethyl cellulose was converted into microspheres by crosslinking with aluminum chloride. Various microsheres with different amounts of crosslinker, biopolymer of various concentrations and molecular weights, and with different pesticide (Aldicarb) contents and pesticide to polymer ratios were prepared. The pesticide encapsulation efficiencies and aldicarb release kinetics of the resultant microcapsules were investigated. It was possible to modify the release behaviour by varying the above parameters and to have drug release with half-lives longer than 100 hours in aqueous media. The release kinetics were described by first order and zero order kinetics.
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    The effects of Ara-C, simvastatin and combo therapy on energy metabolism of HL-60 promyolocytic leukemia cell lines
    (Turkish Biochemistry Society, 2013) Boyunağa H.; Günnur Dikmen Z.; Kenar L.; Saygun O.; Keleş H.; Ugur Ural A.; Lale M.
    Objective: Cancer cells choose their metabolic pathway depending on the oxygen content and substrate concentration of the medium. A wide spectrum of therapeutic agents regulating the energy metabolism of cancer cells are in still in use. Cytosine arabinoside (Ara-C) is a pyrimidine analogue used in the treatment of acute myeloid leukemia (AML) and simvastatin is an inhibitor of HMG-CoA (3-hydroxy-3-methyl-glutaryl-CoA) reductase, which regulates cholesterol biosynthesis. Thus, this study aimed to assess the energy metabolism of HL-60 promyelocytic leukemia cells and healthy white blood cells, additionally to determine the effects of simvastatin and Ara-C, alone or in combination on the energy metabolism of these cells. Materials and Methods: Healthy white blood cells, untreated and treated HL-60 promyolocytic leukemia cell lines were incubated for 4 hours with radiolabelled glucose. Following incubation, lactate, which is one of the end products of the carbohydrate catabolism, and radiolabelled CO2 produced by cells were collected and measured by the liquid scintillation device. In addition, glycogen consumption per hour was determined in each group. Results and Conclusion: We found that untreated HL-60 promyolocytic cells use anaerobic glycolytic pathway whereas healthy white blood cells use aerobic glycolysis for energy gain. It was concluded that combined use of Ara-C and Simvastatin might lead to significant increase in the rate of aerobic glycolysis of HL-60 promyelocytic cells and the metabolism of these leukemia cells become more similar to the metabolism of healthy white blood cells which they originate from. © TurkJBiochem.com.
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    Herbicide penetration through isolated periderm and cuticular membranes
    (1996) Ersoz M.; Duncan H.J.; Lale M.; Ucan H.I.
    The penetration of three herbicides through isolated potato periderm (PM) and pear fruit cuticular membranes (PFCM) as their commercial formulations was examined in two separate experimental methods involving infinite and finite dose systems. The permeability of the three herbicides was found to follow the order of their water solubility re. amitrole> glyphosate> asulam. The results obtained using the infinite and finite dose systems are in general agreement. All three herbicides penetrated rapidly through the PM and PFCM during the initial 1 h treatment period then decreased. The results showed that the penetration for three herbicides under examination depends on water solubility, and also is significantly affected by pH. © Publications Division Selper Ltd., 1996.