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    Impact of Exercise on High-Density Lipoprotein Cholesterol in Adults with Overweight and Obesity: A Narrative Review
    (Annals Applied Sport Science, 2024) Al-mhanna, Sameer Badri; Leao, Cesar; Ghazali, Wan Syaheedah Wan; Mohamed, Mahaneem; Batrakoulis, Alexios; Afolabi, Hafeez Abiola; Abubakar, Bishir Daku
    Background. Sedentary lifestyles and insufficient physical activity contribute significantly to the rising global epidemic of obesity, fostering an environment where excess calories are stored as adipose tissue. Lack of regular physical activity and diminished cardiorespiratory fitness are key factors in the emergence of obesity-related illnesses, leading to cardiovascular and metabolic complications. However, the extent to which low levels of physical activity and obesity directly cause low HDL-C levels is uncertain, and the specific impact of obesity on reducing HDL-C as well as the associated risks are not well clarified. The influence of different types of exercise on HDL function is intricate and depends on various factors, including exercise intensity and individual characteristics. Objectives. This study aims to investigate the effect of exercise on HDL-C levels in overweight and obese adults, as well as review the mechanisms and pathways by which various exercise types influence HDL-C metabolism in this population. Methods. A literature search was conducted using the PubMed, Scopus, and Google Scholar databases. Studies were included if they were published in English. Results. A sequential moderate-tohigh-intensity exercise regimen resulted in sustained or gradual improvements in HDL-C levels. For increased HDL-C levels, frequent moderate-to-high-intensity, long-duration exercise at an aerobic threshold in conjunction with body mass reduction and dietary modification is observed from the reviewed studies. Conclusion. Regular exercise can improve HDL-C levels in overweight and obese individuals. A combination of moderate-to-high-intensity, long-duration exercise at an aerobic threshold with body mass reduction and dietary modification is most effective. Overweight and obese individuals should engage in regular exercise to improve their HDL-C levels and overall health.