Yazar "Leventoglu, Alev" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • [ X ]
    Öğe
    Assessment of ovarian reserve and Doppler characteristics in patients with multiple sclerosis using immunomodulating drugs
    (Galenos Yayincilik, 2009) Cil, Aylin Pelin; Leventoglu, Alev; Sonmezer, Murat; Soylukoc, Rabia; Oktay, Kutluk
    Objective: There is limited data about fertility in multiple sclerosis (MS) patients using immunomodulating drugs and no data exists regarding the ovarian reserve of these patients. Therefore, we aimed to evaluate,the ovarian reserve and doppler characteristics of MS patients using irnmunomodulating drugs. Material and Methods: MS patients using immunomodulating drugs (interferon (1M) beta and glatiramer acetate) and age-matched healthy controls were included in the study. Subjects were examined in the early follicular phase of the menstrual cycle with transvaginal ultrasound to evaluate ovarian volume, antral follicle count (AFC) and ovarian stromal artery Doppler. On the same da blood was taken for determining serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2) levels. A subgroup analysis was also carried out between MS patients using only IFN p and controls to compare the same parameters. Results: Mean ovarian volume and total AFC were lower in MS patients using immunomodulating drugs than in the controls. FSH and E2 levels did not show any differences between the groups, but LH levels were, significantly higher in MS patients. All the Doppler parameters of the ovarian stromal artery were higher in MS patients but not significantly. In the subgroup analysis, the same significant differences were found for ovarian volume, AFC and LH levels. In addition, MS patients showed significantly higher mean pulsatility index measurement than the controls. Conclusion: The findings of this study demonstrated diminished ovarian volume and follicular reserve in MS patients using immunomodulating drugs compared to age matched healthy controls. However, further studies are required to elucidate whether compromised ovarian reserve in MS patients is due to drugs or the disease itself.
  • Küçük Resim
    Öğe
    Dorsal Sural Nerve Conduction Study in Early Diabetic Polyneuropathy Patients and Relationship of Adiponectin and High Sensitive-C Reactive Protein Levels
    (Journal Neurological Sciences, 2009) Kokoglu, Fatma; Leventoglu, Alev; Erdemoglu, A. Kemal
    Objective: In this study, we aimed to investigate the change in dorsal sural nerve (DSN) conduction studies in early diabetic neuropathic patients and to evaluate whether high sensitive C-reactive protein (hs-CRP), inflammatory marker, and adiponektin, important role in insulin resistance and diabetes, have any effect on DSN studies or not. Material and Method: Forty-six patients with early stages (Dyck classification N1)diabetic neuropathy and age-sex matched forty-four control subject were included in the study. Informed consent was obtained after approval of ethical committee. In all subject DSN conduction studies were performed with conventional electrophysiological studies. DSN electrophysiological parameters of diabetics were compared with controls. The relationship between plasma adiponectin and hs-CRP levels and DSN conduction study parameters were analyzed. Results: In diabetic patients, DSN parameters were significantly different than controls. The level of adiponectin was found to be lower in diabetic (p:0.01) but not statistically significant for hs-CRP levels (p:0.40). There was not any relationship between DSN parameters and the level of adiponectin or hs-CRP (p>0.05). Sixty-three % of diabetics, whom routine electrophysiological studies were in normal limits, had abnormal DSN parameters. Fifty% of diabetics had bilateral abnormalities. However, there was no difference in hs-CRP and adiponectin levels between patients with abnormal and normal DSN studies (p>0.05). Conclusion: DSN studies are useful methods to detect subclinical early diabetic polyneuropathy according to the results of our study. Although adiponectin level was found lower in early diabetic neuropathic patients, both adiponectin and hs-CRP do not have any relationship with DSN studies.
  • Küçük Resim
    Öğe
    Migraine-like headache in cerebral venous sinus thrombosis
    (Termedia Publishing House Ltd, 2015) Tan, Funda Uysal; Tellioglu, Serdar; Koc, Rabia Soylu; Leventoglu, Alev
    A 20-year-old female, university student presented with severe, throbbing, unilateral headache, nausea and vomiting that started 2 days ago. The pain was aggravated with physical activity and she had photophobia. She had been taking contraceptive pills due to polycystic ovary for 3 months. Cranial computed tomography was uninformative and she was considered to have the first attack of migraine. She did not benefit from triptan treatment and as the duration of pain exceeded 72 h further imaging was done. Cranial MRI and MR venography revealed a central filling defect and lack of flow in the left sigmoid sinus caused by venous sinus thrombosis. In search for precipitating factors besides the use of contraceptive pills, plasma protein C activity was found to be depressed (42%, normal 70-140%), homocystein was minimally elevated (12.7 mu mol/L, normal 0-12 mu mol/L) and anti-cardiolipin IgM antibody was close to the upper limit. (C) 2015 Polish Neurological Society. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
  • Küçük Resim
    Öğe
    Temporal lobe ictal behavioral patterns in hippocampal sclerosis and other structural abnormalities
    (2005) Kutlu, Gülnihal; Bilir, Erhan; Erdem, Atilla; Gömceli, Yasemin B.; Leventoglu, Alev; Kurt, G.Semiha; Karataş, Ayşe
    Ictal behavioral characteristics may provide clues in determining the nature of the epileptic focus. We defined ictal behavioral characteristics in patients with intractable temporal lobe epilepsy (TLE) who underwent anterior temporal lobectomy (ATL) and lived seizure-free for 2 years of follow-up. Video/EEG data on 282 seizures observed in 48 patients who suffered from TLE and underwent ATL were analyzed. All patients were seizure-free after surgery. We divided the patients into two groups on the basis of the pathological examination. Two hundred and two seizures in 35 patients with hippocampal sclerosis (Group 1) and eighty seizures in 13 patients with other pathological findings, such as tumors, cavernoma, and hamartoma (Group 2), were analyzed. Ictal behavior characteristics were evaluated for each of the seizures recorded in the two groups. Behavioral arrest, bilateral hand automatisms, oral and leg automatisms, and ictal aggression were significantly more frequent in Group 2 (P < 0.05), whereas contralateral dystonia of the upper extremity (P < 0.05), ipsilateral hand automatisms (P < 0.05), ipsilateral hand automatisms in the presence of contralateral dystonia of the upper extremity (P < 0.001), contralateral forced head deviation (P < 0.05), and secondary generalization (P < 0.05) were more significant in Group 1. There was no significant difference in vocalization and ipsilateral nonforced head deviation between the two groups (P > 0.05). The number of seizures observed during ictal speech, crying, and postictal nose wiping was not large enough, so differences could not be analyzed. It was concluded that although ictal behavioral characteristics differed between the two groups, certain behavioral patterns may be helpful in differentiating between hippocampal sclerosis and other pathology. © 2005 Elsevier Inc. All rights reserved.