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    Effects of Pinealectomy and Melatonin Application on Serum Melatonin, Nesfatin-1 and Ghrelin Levels
    (Pera Yayincilik Hizmetleri, 2023) Sönmez, Saadet; Menevşe, Esma; Baltacı, Saltuk Buğra; Ünal, Ömer; Moğulkoç, Rasim; Baltaci, Abdulkerim Kasım
    Objective: In this study, it was aimed to investigate the relationship between the pineal gland and ghrelin and nesfatin-1 hormones in rats. Methods: A total of 36 male rats were used in the study, and the animals were divided into 4 groups. Group 1, Control; Group 2, Pinealectomy (Px); Group 3, Px+Melatonin; Group 4 Melatonin. After the end of the experimental applications, melatonin, ghrelin and nesfatin-1 levels (ELISA) were determined in the blood samples taken from the animals. Results: While pinealectomy resulted in suppression of melatonin levels, melatonin supplementation led to a significant increase in blood melatonin levels (p<0.01). Melatonin supplementation suppressed ghrelin levels, while pinealectomy increased ghrelin levels (P<0.01). On the other hand, Nesfatin-1 levels, which increased with melatonin support, were significantly suppressed by pinealectomy (p<0.01). Conclusion: The findings of the study draw attention to an important relationship between the endocrine activity of the pineal gland and the hormones ghrelin and nesfatin-1, which play a critical role in nutrition. Consequently, administration of melatonin inhibits ghrelin but increases nesfatin-1.
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    Hippocampal ZnT3 (SLC30A3) Levels Reflect Hippocampal Tissue Damage in Chronic Exercising Diabetic Rats
    (Pera Yayincilik Hizmetleri, 2024) Baltacı, Abdulkerim Kasım; Yaslı, Mehmet; Baltacı, Saltuk Buğra; Moğulkoç, Rasim; Menevşe, Esma; Ünal, Ömer
    Objective: In this study, it was investigated how chronic exercise affects hippocampus tissue damage and ZnT3 levels in diabetic rats. Methods: The 40 adult rats were used in the study were divided into 4 equal groups: Control (G1), Exercise Control (G2), Diabetes (G3), Diabetes+Exercise (G4). Diabetes was induced in animals in G3 and G4 by injecting intraperitoneal streptozotocin (STZ) twice, 24 hours apart. The animals in G2 and G4 were runed on the rat treadmill for 45 minutes daily for 4 weeks. MDA (spectrophotometric method) and ZnT3 (ELISA method) levels were determined in hippocampus tissue samples obtained from animals sacrificed at the end of the experimental procedures.Results: In the current study, the highest MDA and lowest ZnT3 levels in the hippocampus tissue were obtained in the diabetes group (G3) (P<0.05). Chronic exercise prevented increased hippocampal tissue damage in diabetic rats and reversed decreased ZnT3 levels (P<0.05). Conclusion: The results of our study showed that 4 weeks of chronic exercise could be prevent increased tissue damage in the hippocampus tissue of diabetic rats and ameliorate the decreased ZnT3 levels. The data obtained in this study indicate that ZnT3 levels in diabetic rats may be an indicator of hippocampal tissue damage.
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    Plasma Leptin, Nesfatin 1, NPY, and Zinc Levels in Obese and Metabolic Syndrome Children
    (Pera Yayincilik Hizmetleri, 2023) Aydoğdu, Adnan; Ünal, Ömer; Baltacı, Saltuk Buğra; Menevşe, Esma; Moğulkoç, Rasim; Erdem, Said Sami; Büyükinan, Muammer
    Objective: The aim of this study is to investigate the relationship between leptin, nesfatin 1 and NPY hormones and zinc in boys and girls diagnosed with metabolic syndrome and obesity. Methods: This study included a total of 6 groups. Group 1 Boy Control, Group 2 Girl Control, Group 3 Obese Boys, Group 4 Obese Girls, Group 5 Boys with Metabolic Syndrome, Group 2 with Girls with Metabolic Syndrome. Plasma leptin, nesfatin-1, NPY (by ELISA method) and serum zinc (by AA method) levels were determined in blood samples obtained from the subjects. Results: Leptin and zinc levels were significantly higher both in boy and girl patients with metabolic syndrome than in obese and control children. Nesfatin-1 and NPY levels were significantly lower both in girl and boy obese and metabolic syndrome children compared to their control groups. Conclusion: In the current study a significant increase in plasma leptin and serum zinc levels and a significant decrease of plasma nesfatin-1 and NPY levels were observed in boys and girls with metabolic syndrome. The findings of our study show that leptin, nesfatin-1 and NPY levels may be important biomarkers in the assessment of metabolic syndrome risk in both girls and boys.
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    Relationship of Dietary Zinc Status with Pubertal Parameters and Cognitive Functions in Male Offspring of Pregnant Rats Fed a Zinc-Deficient Diet
    (Wiley, 2023) Ünal, Ömer; Baltacı, Saltuk Buğra; Mutlu, Elif Gülbahçe; Ünal, Nilüfer Akgün; Moğulkoç, Rasim; Baltacı, Abdulkerim Kasım
    [Abstract No tAvailable]
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    Resveratrol Supplementation is Associated with Elemental Metabolism in Some Tissues of Acute Swimming Rats
    (2023) Baltacı, Abdulkerim Kasım; Arslangil, Dilek; Baltacı, Saltuk Buğra; Moğulkoç, Rasim; Ünal, Ömer
    The aim of this study was to investigate how resveratrol administration affects element metabolism in some tissues in rats undergoing acute swimming exercise. In the study, 28 adult male Wistar rats were used and the animals were divided into 4 groups in equal numbers. Group 1, Control; Group 2, Swimming: The group fed a standard diet and had 30 minutes of acute swimming exercise. Group 3, Resveratrol: The group receiving 10 mg/kg resveratrol supplement for four weeks. Group 4, Resveratrol + Swimming: The group that received 10 mg/kg resveratrol supplement for four weeks and also had 30 minutes of acute swimming exercise. At the end of the four-weeks diet, group 2 and group 4 animals were given 30 minutes of acute swimming exercise. Animals were sacrificed immediately after swimming practices, and testis, kidney, heart and liver tissue samples were taken. Elemental analyzes in tissue samples were determined by atomic emission method. Elements measured in testicular tissue were not affected by exercise and resveratrol applications. Both resveratrol administration and acute swimming exercise resulted in changes in zinc, iron, magnesium, selenium, molybdenum levels in kidney tissue, iron and calcium levels in heart tissue, and zinc, iron and molybdenum levels in liver tissue (p<0.05). The results of study, which revealed that resveratrol administration caused changes in element metabolism in some tissues of rats both during and independently of exercise, can be presented as the first and original finding based on med-line scans.
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    The Effect of Dietary Zinc Status on ZEB1 Levels in Muscle and Bone Tissue in Maternal Zinc Deficiency Rats
    (Wiley, 2023) Alcay, Osman; Mutlu, Elif Gülbahçe; Ünal, Ömer; Baltacı, Saltuk Buğra; Moğulkoç, Rasim; Baltacı, Abdülkerim Kasım
    [Abstract No tAvailable]
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    The Effects of Resveratrol and Melatonin on Cardiac Dysfunction in Diabetic Elderly Female Rats
    (Acad Sciences Czech Republic, Inst Physiology, 2023) Akgün-Ünal, Nilüfer; Özyıldırım, Serhan; Ünal, Ömer; Baltacı, Saltuk Buğra; Moğulkoç, Rasim; Baltacı, Abdulkerim Kasım
    We aimed to investigate the effects of melatonin and resveratrol on diabetes-related papillary muscle dysfunction and structural heart disorders. The protective effect of resveratrol and melatonin supplementation on cardiac functions was investigated in a diabetic elderly female rat model. 16-month-old rats (n=48) were allocated into 8 groups. Group1: Control, Group2: Resveratrol Control, Group3: Melatonin Control, Group4: Resveratrol and Melatonin Control, Group5: Diabetes, Group6: Diabetes Resveratrol, Group7: Diabetes Melatonin, Group8: Diabetes Resveratrol and Melatonin. Streptozotocin was injected intraperitoneally to the rats for experimental diabetes induction. Thereafter, resveratrol (intraperitoneal) and melatonin (subcutaneous) were administered for 4 weeks. Resveratrol and melatonin had a protective effect on the contractile parameters and structural properties of the papillary muscle, which was impaired by diabetes. it has been presented that diabetes impairs the contractile function of the papillary muscle for each stimulus frequency tested and the responses obtained as a result of Ca+2 uptake and release mechanisms from the Sarcoplasmic reticulum, and it has been observed that these effects are improved with resveratrol and melatonin injection. The decrease in myocardial papillary muscle strength in the diabetic elderly female rat can be reversed with the combination of resveratrol, melatonin and resveratrol+melatonin. Melatonin+resveratrol supplementation is no different from melatonin and/or resveratrol supplementation. Resveratrol and melatonin supplementation may have a protective effect on cardiac functions in a diabetic elderly female rat model.
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    The relationship between beta cell activation and SLC30A8/ZnT8 levels of the endocrine pancreas and maternal zinc deficiency in rats
    (Elsevier Gmbh, 2023) Göktepe, Emre; Baltaci, Saltuk Bugra; Ünal, Ömer; Unlukal, Nejat; Moğulkoç, Rasim; Baltaci, Abdulkerim Kasim
    Objectives: Zinc, which is found in high concentrations in the 13-cells of the pancreas, is also a critical component for the endocrine functions of the pancreas. SLC30A8/ZnT8 is the carrier protein responsible for the transport of zinc from the cytoplasm to the insulin granules. The aim of this study was to investigate how dietary zinc status affects pancreatic beta cell activation and ZnT8 levels in infant male rats born to zinc-deficient mothers.Methods: The study was performed on male pups born to mothers fed a zinc-deficient diet. A total of 40 male rats were divided into 4 equal groups. Group 1: In addition to maternal zinc deficiency, this group was fed a zinc -deficient diet. Group 2: In addition to maternal zinc deficiency, this group was fed a standard diet. Group 3: In addition to maternal zinc deficiency, this group was fed a standard diet and received additional zinc sup-plementation. Group 4: Control group. Pancreas ZnT8 levels were determined by ELISA method and insulin -positive cell ratios in 13-cells by immunohistochemistry.Results: The highest pancreatic ZnT8 levels and anti-insulin positive cell ratios in the current study were obtained in Group 3 and Group 4. In our study, the lowest pancreatic ZnT8 levels were obtained in Group 1 and Group 2, and the lowest pancreatic anti-insulin positive cell ratios were obtained in Group 1.Conclusion: The results of the present study; in rats fed a zinc-deficient diet after maternal zinc deficiency has been established shows that ZnT8 levels and anti-insulin positive cell ratios in pancreatic tissue, which is significantly suppressed, reach control values with intraperitoneal zinc supplementation.