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    Awareness and Knowledge of Pneumococcal Vaccination in Cardiology Outpatient Clinics and the Impact of Physicians' Recommendations on Vaccination Rates
    (Mdpi, 2023) Ekin, Tuba; Kis, Mehmet; Gungoren, Fatih; Akhan, Onur; Atici, Adem; Kunak, Aysegul Ulgen; Mutlu, Deniz
    Aim: We aimed to evaluate the awareness of pneumococcal vaccination (PCV13, PPSV23) in general cardiology outpatient clinics and impact of physicians' recommendations on vaccination rates. Methods: This was a multicenter, observational, prospective cohort study. Patients over the age of 18 from 40 hospitals in different regions of Turkey who applied to the cardiology outpatient clinic between September 2022 and August 2021 participated. The vaccination rates were calculated within three months of follow-up from the admitting of the patient to cardiology clinics. Results: The 403 (18.2%) patients with previous pneumococcal vaccination were excluded from the study. The mean age of study population (n = 1808) was 61.9 +/- 12.1 years and 55.4% were male. The 58.7% had coronary artery disease, hypertension (74.1%) was the most common risk factor, and 32.7% of the patients had never been vaccinated although they had information about vaccination before. The main differences between vaccinated and unvaccinated patients were related to education level and ejection fraction. The physicians' recommendations were positively correlated with vaccination intention and behavior in our participants. Multivariate logistic regression analysis showed a significant correlation between vaccination and female sex [OR = 1.55 (95% CI = 1.25-1.92), p < 0.001], higher education level [OR = 1.49 (95% CI = 1.15-1.92), p = 0.002] patients' knowledge [OR = 1.93 (95% CI = 1.56-2.40), p < 0.001], and their physician's recommendation [OR = 5.12 (95% CI = 1.92-13.68), p = 0.001]. Conclusion: To increase adult immunization rates, especially among those with or at risk of cardiovascular disease (CVD), it is essential to understand each of these factors. Even if during COVID-19 pandemic, there is an increased awareness about vaccination, the vaccine acceptance level is not enough, still. Further studies and interventions are needed to improve public vaccination rates.
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    Effectiveness and Safety of Same-Day Discharge After Left Atrial Appendage Closure Using Moderate Conscious Sedation: One-Year Follow-Up Outcomes
    (Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc; Cilingiroglu, Mehmet
    [Abstract No tAvailable]
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    EMCAPT Study: Effect of MitraClip Treatment on the Mitral Annulus and Left Atrial Appendage by Transesophageal Echocardiography
    (Elsevier Science Inc, 2023) Ates, Ismail; Inanc, Ibrahim Halil; Mutlu, Deniz; Polat, Fuat; Kaya, Zeynettin; Arslan, Gamze Yeter; Dogru, Mehmet
    [Abstract No tAvailable]
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    Feasibility of Same-Day Discharge Approach After Transcatheter Mitral Valve Repair Procedures: One-Year Follow-Up Outcomes
    (Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc; Cilingiroglu, Mehmet
    [Abstract No tAvailable]
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    Open Radial Artery (ORAS) Study
    (Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc; Cilingiroglu, Mehmet
    [Abstract No tAvailable]
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    Open Radial Artery Study
    (Excerpta Medica Inc-Elsevier Science Inc, 2024) Inanc, Ibrahim H.; Mutlu, Deniz; Efe, Zeynep N.; Kulaksizoglu, Sibel; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail
    Radial artery occlusion (RAO) has been the most common postprocedural complication of transradial artery access. The optimal method of prevention of RAO is still lacking. In our study, we aimed to evaluate the effect of patent hemostasis on early (24 hours) and late (2 weeks) RAO prevention. The Open Radial Artery Study was a single-arm, prospective, and multicenter study. The primary end points were early and late RAO at the vascular access site after transradial coronary procedures. Secondary end points were access site hematoma, pseudoaneurysm formation, arteriovenous fistula, and nerve injury. A total of 2,181 patients were analyzed (67% male, mean age 68 years). The mean interventional duration and hemostatic times were 75.6 +/- 55.6 and 60 +/- 5.6 minutes, respectively. Radial artery spasm occurred in 10% of patients (n = 218). Catheter kinking, radial artery rup-ture, or dissection were not observed during the procedure. RAO, hematoma, pseudoa-neurysm, arteriovenous fistula, or nerve damage was not observed in any of the patients in the early or late period. In patients who undergo coronary diagnostic or interventional procedures through transradial artery access, the patent hemostasis method seems a criti-cal step in the prevention of early and late RAO. (c) 2023 Elsevier Inc. All rights reserved. (Am J Cardiol 2024;211:130-136)
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    Transcatheter mitral valve repair in a liver transplant candidate
    (Wiley, 2022) Ates, Ismail; Mutlu, Deniz; Inanc, Ibrahim Halil; Marmagkiolis, Konstantinos; Iliescu, Cezar A.; Kilic, Ismail Dogu; Cilingiroglu, Mehmet
    Untreated severe mitral regurgitation (MR) is associated with poor outcomes due to the adverse consequences of long-standing volume overload on the left ventricle and left atrium, which leads to pulmonary hypertension and right-sided heart failure. Early intervention results in favorable long-term outcomes making appropriate timing of intervention very critical. We present a 53-year-old male with severe symptomatic MR and right sided-heart failure which progressed to cardiac cirrhosis necessitating enrollment to the liver transplant list. Transcatheter mitral valve repair (TMVR) using MitraClip implantation resulted in impressive clinical improvement and resolution of cirrhosis. Eventually, the patient was taken off the transplant list. Treatment of severe MR may lead to improvements in congestive hepatopathy.
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    Use of IVOCT for Assessment of the Lesion Characteristics as Well as Evaluation of Vascular Healing Effects of Different Technologies in PAD Patients
    (Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc; Cilingiroglu, Mehmet
    [Abstract No tAvailable]
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    Use of SAFARI 2 as Workhorse Wire for Left-Sided Structural Heart Interventions
    (Elsevier Science Inc, 2023) Inanc, Ibrahim Halil; Mutlu, Deniz; Rollefson, William; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Feldman, Marc
    [Abstract No tAvailable]
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    Use of SAFARI 2n° as workhorse wire for left-sided structural heart interventions
    (Elsevier Inc, 2024) Inanc, Ibrahim H.; Mutlu, Deniz; Marmagkiolis, Kostas; Iliescu, Cezar; Ates, Ismail; Cilingiroglu, Mehmet
    Background: With the advances in percutaneous treatment technologies, the left atrial appendage occlusion (LAAO) and the transcatheter mitral valve repair using MitraClip (TMVR) are increasingly being performed today. The SAFARI 2n degrees guidewire is primarily used during transcatheter aortic valve implantation (TAVI), our group has also been using it during MitraClip and LAAO procedures. Our clinical study aimed to share our data on the safety and effectiveness for the use of the SAFARI 2n degrees guidewire during MitraClip or LAAO procedures. Methods: This study included a total of 1730 patients (948 patients of MitraClip and 782 of LAAO). It was designed as single arm, retrospective, and multicenter between July 2016 and August 2022. SAFARI 2n degrees guidewire was used exclusively during all the procedures. Results: A total of 1730 patients (male 55.8 %) were included in the study. There was no guidewire-related complications, stroke/transient ischemic attack, bleeding (minor/major/life-threatening), need for cardiac surgery, pneumonia, and vascular dissection/rupture in patients undergoing LAAO. There were 2 device-related pericardial effusions without tamponade. No stroke/transient ischemic attack, bleeding (minor/major/life-threatening), mortality, need for cardiac surgery, pneumonia, guidewire-related complication, pericardial effusion, vascular dissection/rupture, or clip embolization was observed in patients undergoing MitraClip. Conclusions: By taking advantage of its pre-shaped structure, the SAFARI 2n degrees guidewire seems to offer a reliable and safe device delivery for both MitraClip and LAAO procedures as a regular work horse wire. Our results should be confirmed by larger randomized or prospective trials.