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Öğe Comparison of uterine artery Doppler sonography, saline infusion sonography and endometrial biopsy in premenopausal patients with abnormal uterine bleeding who were found to have endometrial polyps(2010) Koç H.; Noyan V.; Yücel A.; Sağsöz N.Objective: The aim of this study was to compare uterine artery doppler sonography, saline infusion sonography and endometrial biopsy results in premenopausal patients with abnormal uterine bleeding. Material and Methods: This study was performed on 60 premenopausal patients who had abnormal uterine bleeding and whose endometrial thickness were ? 5 mm. Transvaginal ultrasonography, uterine artery Doppler sonography and saline hydrosonography were performed for each patient. Afterwards, endometrial biopsies were performed and sent to the pathology department. After the pathology results were delivered, 25 patients were included in the endometrial polyp group. Patients with abnormal uterine bleeding, who didn't have any intracavitary lesions were considered as the control group. The result for transvaginal ultrasonography, uterine artery doppler sonography and saline hydrosonography were compared with pathology results. Results: The mean uterine artery resistance index value in the endometrial polyp group was 0.63 ± 0.2 and in the control group it was 0.66 ± 0.17 (p= 0.48). The mean uterine artery pulsatility index in the endometrial polyp group was 1.75 ± 0.74 and in the control group it was 1.95 ± 0.63 (p= 0.31). The sensitivity, specificity, positive predictive value and negative predictive value of saline hydrosonography in directly visualizing endometrial polyps were 96%, 84.6%, 95.7% and 85.7%, respectively (p< 0.05). Conclusion: Uterine artery doppler sonography dose not have any additive value to conventional ultrasonography and salin hydrosonography, in differentiating endometrial polyps from patients with abnormal uterine bleeding who do not have any intracavitary lesions. Copyright © 2010 by Türkiye Klinikleri.Öğe Plasma antioxidant enzyme levels in smoker and non-smoker pregnant women and their correlation with uterine arterial doppler parameters(Scientific Publishers of India, 2018) Celikel O.O.; Noyan V.; Caglayan O.Introduction: Cigarettes contain many free radicals and cause oxidative stress in the body. Its contents decrease blood fluidity and blood stream by affecting the vascular endothelium; further, they directly or indirectly impair placental perfusion. Material and method: Catalase (CAT), malondialdehyde (MDA) and total sulfhydryl (SH) levels were analysed in venous blood specimens obtained from 49 smoker and 35 non-smoker pregnant women (age, 18-35 y) who were in the second trimester. Uterine arterial Doppler ultrasonography was performed to evaluate uterine perfusion. Pulsatile index (PI), resistance index (RI) and systole/diastole ratio (S/D) was measured. The smoker group was further subdivided into two groups: 1. those who smoked for <5 y and 2. Those who smoked for >5 y. Obtained data were analysed using the SPSS 11 statistical programme. Results: No significant differences were observed between the smoker and non-smoker groups in terms of demographic parameters and right–left uterine arterial Doppler parameters. The mean S/D ratio was significantly higher in the smoker group (P=0.01). The mean PI, mean RI and plasma MDA, CAT and total SH levels were similar in both groups. Although not statistically significant, the mean PI, RI and S/D ratio values of the smoker pregnant women who smoked for ? 5 y was found to be higher than of those who smoked for <5 y. Conclusion: There is no correlation between plasma antioxidant enzyme levels and uterine artery Doppler parameters; however, the duration of smoking may affect uterine perfusion. © 2018, Scientific Publishers of India. All rights reserved.Öğe Plasma apelin levels in patients with polycystic ovary syndrome(2012) Gören K.; Sağsöz N.; Noyan V.; Yücel A.; Çağlayan O.; Bostanci M.S.Objective: The aim of the study was to evaluate plasma apelin levels in patients with polycystic ovary syndrome (PCOS) and healthy controls. Material and Methods: Plasma apelin levels, serum lipid levels, serum hormone levels, and homeostasis model assessment-insulin resistance (HOMA-IR) values of 32 patients with PCOS and 31 healthy women forming the control group were checked. Results: Plasma apelin levels of the PCOS group (0.350±0.083 ng/ml) were significantly higher than those of the control group (0.246±0.045 ng/ml) (p<0.001). No significant correlation was detected between apelin levels and biochemical or clinical data in PCOS group. Conclusion: Plasma apelin levels were significantly higher in PCOS patients. © Copyright 2012 by the Turkish-German Gynecological Education and Research Foundation.Öğe Total and lipid bound sialic acid levels in patients with polycystic ovary syndrome(AVES, 2012) Özcan A.; Yücel A.; Noyan V.; Sağsöz N.; Çağlayan O.Objective: To evaluate serum total and lipid bound sialic acid (TSA&LBSA) levels in patients with polycystic ovary syndrome (PCOS). Material and Methods: Forty women with PCOS and 35 healthy controls were enrolled in the study. Serum TSA, LBSA, follicle stimulating hormone, lutenizing hormone, estradiol, thyroid stimulating hormone, prolactin, dehydroepiandrosterone sulphate, androstenedione, free testosterone, total testosterone, 17-OH progesterone, sex hormone binding globulin, cortisol, total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein were measured in each subject. Insulin resistance was estimated by fasting insulin level, fasting glucose: insulin ratio and 75-g glucose tolerance test for 2 hours. Results: Serum TSA levels were not significantly different between the groups. Serum LBSA levels were higher in patients with PCOS compared to the control group. TSA was correlated with androstenedione and HOMA-IR in the PCOS group. Positive correlations were found between LBSA and dehydroepiandrosterone sulphate in patients with PCOS. After correction for BMI, the only existing significant correlation was between LBSA and follicle stimulating hormone. Conclusion: Serum LBSA levels, which has previously been found to be higher in cardiovascular diseases and diabetes mellitus, are elevated in PCOS. © 2012 by the Turkish-German Gynecological Education and Research Foundation.
