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Öğe Cellular enzyme values in hunter/jumper and dressage horses with dermatophytosis(Arquivo Brasileiro Medicina Veterinaria Zootecnia, 2009) Ural, K.; Yagci, B.; Ocal, N.…Öğe The efficacy of a combination of azithromycin and toltrazuril for the treatment of calves naturally infected with cryptosporidiosis: a randomised, double-blind, placebo-controlled comparative clinical trial(Czech Academy Agricultural Sciences, 2017) Yagci, B. B.; Ocal, N.; Duru, S. Yasa; Akyol, M.Cryptosporidium spp. are important emerging pathogens that can cause infections in humans, especially in immunosuppressed patients. Treatment of diseased calves that shed the infectious stage of the protozoon is critically important to prevent contamination by Cryptosporidium spp. oocysts. The objective of this study was to determine if a combination of azithromycin and toltrazuril provides a better treatment option for calf crypto-sporidiosis compared to the use of either agent alone. A total of 55 Holstein calves with cryptosporidiosis were randomly assigned into four groups. Group A (n = 15) received azithromycin at a dose of 20 mg/kg/day per os for six days, group T (n = 15) received toltrazuril at a dose of 20 mg/kg per os every other day on a total of three occasions, and group AT (n = 15) received the combination of both drugs. The control group (n = 10) received purified water. A randomised, placebo-controlled, double-blinded clinical study was designed. The number of oocysts in faeces and clinical parameters were followed daily. Selected haematological and biochemical parameters were measured at the beginning and end of the study. The calves receiving the combination of azithromycin and toltrazuril exhibited a better clinical score as well as the lowest number of oocysts at all time-points. In conclusion, the combination of azithromycin and toltrazuril promotes rapid clinical recovery in calves infected with cryptosporidiosis and stops oocyst shedding. Thus, the combination of azithromycin and toltrazuril is an effective alternative treatment option for calf cryptosporidiosis.Öğe Neospora caninum: the First Demonstration of the Enteroepithelial Stages in the Intestines of a Naturally Infected Dog(Elsevier Sci Ltd, 2015) Kul, O.; Atmaca, H. T.; Anteplioglu, T.; Ocal, N.; Canpolat, S.A 1.5-month-old Kangal breed puppy from a dairy cattle farm died after showing severe diarrhoea and incoordination. Necropsy examination revealed multifocal pulmonary consolidation and necrosis and fibrinohaemorrhagic enteritis. Microscopically, there was necrotic and purulent bronchopneumonia, myocarditis and non-purulent encephalitis. In the jejunum and ileum there was villous atrophy and crypt hyperplasia with oocyst-like and schizont-like structures in the epithelia. Immunohistochemically, Neospora caninum antigen was detected in association with the intestinal protozoal structures, degenerative neurons and areas of necrosis in the lungs and heart. Polymerase chain reaction confirmed that the organism was N. caninum and not Toxoplasma gondii. The seroprevalence for N. caninum was 74.2% (49/66 animals) for the cattle and 57.1 A (4/7 animals) for dogs on this farm. This report documents fatal systemic neosporosis and enteroepithelial stages of N. caninum in a naturally infected puppy. To the authors' knowledge, this is the first definition of intestinal neosporosis in a naturally infected dog as well as the first evidence of fatal canine neosporosis in Turkey. (C) 2015 Elsevier Ltd. All rights reserved.Öğe Prevalence of Clinical Dermatophytosis and Oxidative Stress in Cattle(Medwell Online, 2010) Yildirim, M.; Cinar, M.; Ocal, N.; Yagci, B. B.; Askar, S.In this study, skin scrapings and hair samples were collected from 50 cattle with clinically suspected of dermatophytosis in the province of Kirikkale, Turkey. Moreover, blood samples were collected from 10 clinically healthy cattle and 37 cattle with clinically suspected of dermatophytosis to investigate the influence of dermatophytosis on some biochemical profiles, lipid peroxidation and antioxidant system. The collected samples were directly examined for fungal elements by direct microscopy. The isolation was made from clinically diagnosed about 50 cattles belonging to Dermatophytosis by 22 (44%). The distribution of isolates was Trichophyton verrucosum 19/50 (38%), Trichophyton mentagrophytes 3/50 (6%), respectively. The influence of dermatophytosis on plasma Malondialdehyde (MDA), total protein, albumin, uric acid levels, vitamin A and beta-carotene, vitamin C levels on serum Cu, Zn and Fe elements, in the erythrocyte Catalase (CAT) and Superoxide Dismutase (SOD) enzyme activity was investigated. There was no significant difference between the control and dermatophitic groups for total protein, albumin, vitamin A and C values. However, plasma MDA, erytrocyte CAT (p<0.05) levels and SOD (p<0.01) enzyme activity and plasma beta-carotene, uric acid and serum Zn, Cu (p<0.05), Fe (p<0.01) levels in dermatophitic cattles were statistically lower than those of control group. The result of the study revealed that cattle dermatophytosis is highly prevalent in the Central of Anatolia, Kirikkale province. In addition, the effects of lipid peroxidation and antioxidant system have been determined during the pathogenesis of disease.
