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  • Küçük Resim
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    The Effects Of Bisphosponates Therapy In Patients With Postmenapousal Rheumatoıd Arthritis
    (2018) Taşkın, Sühan; Çakıt, Mehmet Onat; Vural, Secil Pervane; Okumuş, Müyesser; Nacır, Barış; Çakıt, Burcu Duyur; Genç, Hakan
    INTRODUCTION: Bisphosphonates therapy may be potentialadjunctive therapy agents of synthetic disease modifying antirheumaticdrugs in rheumatoid arthitis patients who have contraindications andwho are intolerant to biologics. The aim of this retrospective study wasto evaluate the effects of adjunctive Bisphosphonates on disease activityof our patients with rheumatoid arthitis who underwent the syntheticdisease modifying antirheumatic drugs therapy.MATERIAL AND METHOD: Retrospective data were collectedfrom patient records of our Rheumatology department outpatientclinic. Files of 207 patients who are over 45 years old and whose bonemineral density were evaluated in the previous year were screened forthe study. Patients demographics, medications, disease duration, theage of disease onset, anti-Cyclic Citrullinated Peptid, Rheumatoid factorpositivily, Disease activity scores positivity were recorded. Bone mineraldensitometry analyses were performed in patients by Dual EnergyX-ray Absorptiometry. 106 patients (89 women, 17 men) who receivedbisphosponates therapy for 1 year constituted group1 and 101 patients (81women 20 men) who did not receive bisphosponates constituted group 2.RESULTS: The mean age of group 1 was 65.02 11.14 years and group2 was 63.649.1 years (p 0.05). There was no statistically significantdifference between groups in terms of age, gender and disease durationparameters. There were no statistically significant difference according todisease modifying antirheumatic drugs type and dosages between groups(p 0.05) but in group 1, prednisolone users were more than group 2(p 0.001). The mean tender joint count changes were -0.640.63 ingroup 1 and 0.420.62 in group 2 (p0.001). There were no significantdifference according to bone mass density values of prednisolone usersand nonusers at baseline and after 1 year.DISCUSSION: For patients who cannot be treated with biological agents,effective prevention of focal bone damage and generalized bone losswill require new treatment strategies, like concomitant administrationof drugs with specific effects on bone metabolism. Bisphosponates canprevent generalized bone loss and therapies may yield both medical andeconomic benefits in patients with rheumatoid arthritis.CONCLUSION :We think that adjunctive bisphosponates may provideadditional benefits in older rheumatoid arthritis patients with systemicand regional bone loss. However, further studies are needed to determinewhether bisphosphonate therapies must be administered routinely with thedisease modifying antirheumatic drugs and biologics.
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    EVALUATION OF THE EFFECTIVENESS OF ALPHA LIPOIC ACID IN THE TREATMENT OF BELL'S PALSY
    (2022) Taş, Burak Mustafa; Şimşek, Gökce; Okumuş, Müyesser; Tozar, Mesut
    Objective: This study aims to evaluate the efficacy of alpha-lipoic acid in the treatment of Bell’s palsy by using the House-Brackmann grading system and electromyography.Material and Methods: A total of 33 patients were included in this retrospective study. Patients were divided into two groups. Group 1 included 18 patients who received 300 mg daily alpha-lipoic acid in addition to Bell’s palsy treatment. Group 2 included 15 patients who only received Bell’s palsy treatment. House-Brackmann grading score at admission, 21st day and at 3rd month were noted in both groups. The results of electromyography performed at 21st day were also scanned. Patients were classified as good prognosis (neuropraxia) and poor prognosis (axonotmesis and neurotmesis) according to electromyography results. The two groups were compared according to House-Brackmann grades and electromyography results.Results: Group 1 consisted of 10 women and 8 men, while Group 2 consisted of 6 women and 9 men. There was no difference between the two groups according to whether Bell’s palsy was on the right or left side. House-Brackmann grading score of the groups at 21st day and 3rd month were significantly lower than House-Brackmann grading score at admission. There was no significant difference between the two groups according to House-Brackmann grades. There was no difference between the groups in terms of compound muscle action potential ratio and prognosis.Conclusion: Although alpha-lipoic acid is used for nerve regeneration in various diseases, it did not demonstrate a significant effect on Bell’s palsy treatment in our study.
  • Küçük Resim
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    Kupa Tedavisi ve Hacamat
    (2016) Okumuş, Müyesser
    Antik çağlardan bu yana, tamamlayıcı ve geleneksel tedavi, insan sağlığı için önemli bir rol oynamıştır.Tamamlayıcı ve geleneksel tedavi uygulamalarından olan kupa (yaş veya kuru kupa tedavisi) tedavisikonvansiyonel tedaviye cevap vermeyen birçok bozukluklarda terapötik etkiye sahip olduğu iddiaedilmektedir. Bu derleme, ilgili literatürün ışığında kupa tedavisi tanımlamasını, tarihçesini, uygulamatekniklerini, mekanizmasını, uygulama bölgelerini ve yan etkilerini özetlemektedir.
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    Prolotherapy Versus Corticosteroid Injections and Phonophoresis for the Treatment of Plantar Fasciitis: A Randomized Controlled Trial
    (Wiley-Blackwell, 2015) Demir, Gülseren; Okumuş, Müyesser; Karagöz, Aynur; Kültür, Turgut
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    The Effect of Lower Urinary Tract Dysfunction on Quality of Life and Caregiver Burden in Stroke Patients
    (2023) Agir, Hatice; Okumuş, Müyesser; Keskin, Dilek
    ABSTRACT Objective: Lower urinary tract dysfunction (LUTD) is an important burden factor for patients and their caregivers. In this study, we aimed to investigate the impact of LUTD on caregiver burden and quality of life of stroke patients. Material and Methods: The study included 75 stroke patients and their caregivers followed in the physical medicine and rehabilitation clinic. Zarit Caregiver Burden Scale (ZCBS) was used to evaluate the caregiver burden, and the Incontinence Quality of Life (I-QOL) Scale was used to evaluate the effect of urinary symptoms on patients' quality of life. Urinary symptoms of the patients were evaluated with Danish Prostatic Symptom Score (DAN-PSS-1), functional status and activities of daily living were evaluated with Functional Independence Measure (FIM) and Barthel Index (BI). The patient's mood status was questioned with Hospital Anxiety and Depression Scale (HADS). Results: A total of 75 stroke patients, 38 (50.7%) women, and 37 (49.3%) men, with a mean age of 61.76±10.6 (37-80) years, and 75 caregivers participated in the study. A statistically significant difference was observed regarding FIM, BI, I-QOL and subgroups, DAN-PSS-1 scores between low/moderate and severe/overburden caregivers (p<0.001). The ZCBS scores of the caregivers of the patients whose HADS were higher than normal were significantly higher (p<0.01 and p<0.001, respectively). A statistically significant correlation was observed between the patients' DAN-PSS-1 and I-QOL-total and subgroups, BI, FIM total, and sub-scores (p<0.01). Conclusion: We found that LUTD in stroke patients reduces the patient's quality of life and increases the caregiver burden.
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    Öğe
    THE EFFECTS OF BISPHOSPONATES THERAPY IN PATIENTS WITH POSTMENAPOUSAL RHEUMATOID ARTHRITIS
    (2018) Taşkın, Sühan; Çakıt, Mehmet Onat; Vural, Secil Pervane; Okumuş, Müyesser; Nacır, Barış; Çakıt, Burcu Duyur; Genç, Hakan
    INTRODUCTION: Bisphosphonates therapy may be potentialadjunctive therapy agents of synthetic disease modifying antirheumaticdrugs in rheumatoid arthitis patients who have contraindications andwho are intolerant to biologics. The aim of this retrospective study wasto evaluate the effects of adjunctive Bisphosphonates on disease activityof our patients with rheumatoid arthitis who underwent the syntheticdisease modifying antirheumatic drugs therapy.MATERIAL AND METHOD: Retrospective data were collectedfrom patient records of our Rheumatology department outpatientclinic. Files of 207 patients who are over 45 years old and whose bonemineral density were evaluated in the previous year were screened forthe study. Patients demographics, medications, disease duration, theage of disease onset, anti-Cyclic Citrullinated Peptid, Rheumatoid factorpositivily, Disease activity scores positivity were recorded. Bone mineraldensitometry analyses were performed in patients by Dual EnergyX-ray Absorptiometry. 106 patients (89 women, 17 men) who receivedbisphosponates therapy for 1 year constituted group1 and 101 patients (81women 20 men) who did not receive bisphosponates constituted group 2.RESULTS: The mean age of group 1 was 65.02 ± 11.14 years and group2 was 63.64±9.1 years (p > 0.05). There was no statistically significantdifference between groups in terms of age, gender and disease durationparameters. There were no statistically significant difference according todisease modifying antirheumatic drugs type and dosages between groups(p > 0.05) but in group 1, prednisolone users were more than group 2(p < 0.001). The mean tender joint count changes were -0.64±0.63 ingroup 1 and 0.42±0.62 in group 2 (p<0.001). There were no significantdifference according to bone mass density values of prednisolone usersand nonusers at baseline and after 1 year.DISCUSSION: For patients who cannot be treated with biological agents,effective prevention of focal bone damage and generalized bone losswill require new treatment strategies, like concomitant administrationof drugs with specific effects on bone metabolism. Bisphosponates canprevent generalized bone loss and therapies may yield both medical andeconomic benefits in patients with rheumatoid arthritis.CONCLUSION :We think that adjunctive bisphosponates may provideadditional benefits in older rheumatoid arthritis patients with systemicand regional bone loss. However, further studies are needed to determinewhether bisphosphonate therapies must be administered routinely with thedisease modifying antirheumatic drugs and biologics.
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    Öğe
    The Relationship Between Fear of Movement, Balance and Fear of Falling in Stroke Patients with Shoulder Pain
    (2021) Demirci, Cevher Savcun; Sertel, Meral; Önal, Birol; Arslan, Saniye Aydoğan; Yümin, Eylem Tütün; Okumuş, Müyesser
    Objective: Shoulder pain is a common problem after stroke and causes functional limitations in patients. Pain leads to keep away from the movement and physical activities. The aim of this study was to evaluate the fear of movement in stroke patients with shoulder pain and to investigate its relationship with balance and fear of falling. Material and Methods: Forty six stroke patients were included in the study and divided into two groups, with and without shoulder pain. Fear of movement was evaluated by the Tampa Scale for Kinesiophobia, functional balance was by the Berg Balance Scale and fear of falling was by the Tinetti’s Falls Efficacy Scale. Results: The mean age of patients with and without pain were 65.60±11.37 years and 60.56±14.18 years respectively. In the shoulder painful group, it was determined that there was a negative correlation between balance and the fear of movement (r=-0.417; p=0.048) and that there was a positive correlation between the fear of falling and the fear of movement (r=0.429; p=0.041). In the shoulder painless group, there was no significant correlation (p>0.05). There was a statistically significant difference between the kinesiophobia values of two groups (p?0.05). Conclusion: When balance problems and falls observed in stroke patients are combined with pain and fear of movement, it becomes important to take into account and evaluate the fear of movement in rehabilitation practices.