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    Öğe
    A New Predictor for Insulin Resistance in Polycystic Ovary Syndrome: InsuTAG
    (Bentham Science Publ Ltd, 2024) Omma, Tülay; Gökçe, Aksanur; Çelik, Mustafa; Karahan, İrfan; Çulha, Cavit; Gülçelik, Neşe Ersöz
    Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among women of reproductive age. PCOS leads to metabolic dysfunction such as dyslipidemia, obesity, and glucose intolerance based on hyperandrogenemia, hyperinsulinemia, and dysregulated adipokine secretion.Objective: The aim of this study was to investigate whether a new marker, InsuTAG (fasting insulinxfasting triglycerides) could predict insulin resistance (IR) in patients of PCOS.Methods: In this study, retrospective data of 300 female patients diagnosed with PCOS were analyzed. The relationship between InsuTAG and HOMA-IR, TyG, and TG/HDL-C scores related to insulin resistance was evaluated. In addition, the distribution of the cases according to the cut-off values was determined.Results: Log-transformed forms of InsuTAG and HOMA-IR, TyG and TG/HDL-C results were positively correlated, respectively. (r = 0.85, p < 0.001; r = 0.78, p < 0.001; r = 0.72, p < 0.001). Sensitivity, specificity, positive predictive value and negative predictive values for InsuTAG were calculated as 85%, 85%, 82% and 88%, respectively.Conclusion: This study is the first to compare the InsuTAG, another predictor of insulin resistance, with other IR markers in women with PCOS. InsuTAG is a novel biomarker based on plasma sampling of insulin and triglyceride, with minimally invasive, inexpensive and orientally accessible features.
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    Öğe
    THE EFFECT OF ACROMEGALY ON OLFACTORY FUNCTIONS
    (2021) Akkoca, Özlem; Kavuzlu, Ali; Omma, Tülay; Öçal, Ramazan; Şimşek, Gökce; Kaytez, Selda; Çelik, Hatice
    Objective: The aim of this study is to compare the olfactory functions of patients with active acromegaly and patients in biochemical remission. Meterials and Methods: The study was conducted by forming 2 groups of patients diagnosed with acromegaly and a control group. Group 1 consisted of active acromegaly patients. Group 2 included patients who were determined to have biochemical remission. Group 3 were healthy volunteers. The olfactory functions were evaluated with the Brief Smell Identification Test(BSIT). Results: A total of 69 patients were included in the study. The median value of blood insulin-like growth factor 1 (IGF-1) in Group 1 was statistically significantly higher than in Group 2(p <0.001). A statistically significant difference was found between the groups in respect of the BSIT scores(p <0.001). BSIT scores in Group 1 were observed to be significantly lower than both Group 2 and Group 3 (p = 0.001). There was no significant difference between Group 2 and Group 3(p = 1.000). A negative correlation was determined between the BSIT scores and IGF-1 values in Group 1(r = -0.983, p <0.001), (r = -0.629, p <0.01). Conclusions: Active acromegaly causes a decrease in olfactory functions compared to the patients in biochemical remission and this function loss is negatively correlated with IGF-1 levels.