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THE EFFECT OF ACROMEGALY ON OLFACTORY FUNCTIONS
(2021) Akkoca, Özlem; Kavuzlu, Ali; Omma, Tülay; Öçal, Ramazan; Şimşek, Gökce; Kaytez, Selda; Çelik, Hatice
Objective: The aim of this study is to compare the olfactory functions of patients with active acromegaly and patients in biochemical remission. Meterials and Methods: The study was conducted by forming 2 groups of patients diagnosed with acromegaly and a control group. Group 1 consisted of active acromegaly patients. Group 2 included patients who were determined to have biochemical remission. Group 3 were healthy volunteers. The olfactory functions were evaluated with the Brief Smell Identification Test(BSIT). Results: A total of 69 patients were included in the study. The median value of blood insulin-like growth factor 1 (IGF-1) in Group 1 was statistically significantly higher than in Group 2(p <0.001). A statistically significant difference was found between the groups in respect of the BSIT scores(p <0.001). BSIT scores in Group 1 were observed to be significantly lower than both Group 2 and Group 3 (p = 0.001). There was no significant difference between Group 2 and Group 3(p = 1.000). A negative correlation was determined between the BSIT scores and IGF-1 values in Group 1(r = -0.983, p <0.001), (r = -0.629, p <0.01). Conclusions: Active acromegaly causes a decrease in olfactory functions compared to the patients in biochemical remission and this function loss is negatively correlated with IGF-1 levels.