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    Effects of Meloxicam on oxidative deterioration due to exercise in horses
    (Ecole Nationale Veterinaire Toulouse, 2011) Gunes, V.; Cinar, M.; Onmaz, A. C.; Atalan, G.; Yavuz, U.
    In this study, the effects of meloxicam, a not steroidal anti-inflammatory drug (NSAID), on the oxidative status were evaluated in exercised horses. Sixteen healthy horses were normally trained for 2 hours and immediately after, the half of them were intravenously injected by a single dose of meloxicam (0.6 mg/kg) whereas the 8 others were treated with NaCl 0.9% in the same way. Physical parameters (rectal temperature, heart and respiratory frequencies) and eventual inflammatory clinical signs, venous blood gas, serum biochemical markers such as glucose and protein concentrations, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) activities and plasma malondialdehyde (MDA) concentrations and superoxide dismutase (SOD) activities were investigated before (-2 hours), immediately after the exercise and 1, 3, 5 and 7 hours after. Immediately after the exercise which has induced a transient CO2 accumulation coupled to a high and prolonged O-2 consumption, the physical parameters, the serum AST activities and the plasma MDA concentrations significantly increased whereas the plasma SOD activities were greatly reduced. Compared to the control horses, the meloxicam treated horses exhibited a more rapid clinical recovery associated to a more efficient CO2 elimination and tissue O-2 delivery, less prolonged AST variations and marked increases in the SOD activities in the post-exercise period. These results demonstrate that a strenuous exercise induced an oxidative stress in horses and that meloxicam affects the oxidative status by strengthening the SOD activity.
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    Oxidative stress in horses after a 12-hours transport period
    (Ecole Nationale Veterinaire Toulouse, 2011) Onmaz, A. C.; Van den Hoven, R.; Gunes, V.; Cinar, M.; Kucuk, O.
    The purpose of this study was to evaluate some oxidative stress indicators of horses exposed to transport stress. The study was carried out on 10 healthy mixed breed adult horses, transported by road on 538 km. Physical (rectal temperature, respiratory and heart rates), haematological, biochemical and oxidative stress (Malonedialdehyde (MDA) and superoxide dismutase (SOD)) parameters were determined before and after transportation. The transportation has induced significant (P < 0.05) increases in respiratory and heart rates, in haematocrit and in glycaemia, the other clinical, haematological and biochemical parameters remaining unchanged. The occurrence of an oxidative stress induced by a 12 hour transport period was evidenced by a marked and significant increase of the plasma MDA concentrations coupled to a significant reduction in the plasma SOD activity compared to baseline values. In conclusion, the long-distance transport has negatively affected the oxidant/antioxidant status in horses.