Yazar "Orbak, Zerrin" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim
    Öğe
    Body hair scores and total hair diameters in healthy women in the Kirikkale Region, of Turkey
    (Yonsei Univ College Medicine, 2004) Sağsöz, Nevin; Kamacı, Mansur; Orbak, Zerrin
    It was aimed to determine the normal hair scores of women of Kirikkale region according to the Ferriman-Gallwey scale and to investigate the relationship between the hair shaft diameter and hair scores. Hair scores were calculated in 204 healthy women, and hair shaft diameters were measured from the hair samples collected from 60 patients. Body mass index, waist to hip ratio, insulin resistance and blood androgen levels were determined. Neutral, hormonal and total hair scores were 2.1 +/- 1.4, 3.1 +/- 2.7 and 5.2 +/- 3.6, respectively. The average total hair diameter and hormonal hair diameter were 191.93 +/- 90.49 mum and 121.8 +/- 75.9 mum respectively. The correlation between total hair diameter and total hair score was statistically significant (r = 0.704 p < 0.001). Also, the correlation between hormonal hair diameter and hormonal hair score was statistically significant (r = 0.724 p < 0.001). While hair scores and diameters show meaningful positive correlation with androgen levels, they show negative correlation with age. In our population, 95% value of total hair score was 11, and for the hormonal score, it was 9. Hair diameters increase with hair score, regardless of total or hormonal of hair scores. Hair scores and hair diameters may be affected by blood androgens in healthy women.
  • Küçük Resim
    Öğe
    The effects of oral contraceptives including low-dose estrogen and drospirenone on the concentration of leptin end ghrelin on polycystic ovary syndrome
    (Elsevier Science Inc, 2009) Sağsöz, Nevin; Orbak, Zerrin; Noyan, Volkan; Yücel, Aykan; Uçar, Banu; Yıldız, Leyla
    Objective: To evaluate short-term leptin and ghrelin concentrations in women with polycystic ovary syndrome (PCOS) who use low-dose oral contraceptives containing drospirenone. Design: Prospective study. Setting: Department of obstetrics and gynaecology in a university hospital. Patient(s): Twenty women with PCOS were enrolled in the study. Intervention(s): A low-dose oral contraceptive containing ethinyl estradiol and drospirenone was given for three cycles. Main Outcome Measure(s): Serum androstenedione, free T, T, dehydroepiandrosterone sulphate, sex hormone-binding globulin, FSH, LH, E-2, lipid profiles, leptin, and ghrelin levels were measured in each subject. Insulin resistance was estimated by the homeostasis model assessment-insulin resistance (HOMA-IR). Result(s): While leptin concentrations did not change with therapy, ghrelin levels increased statistically. Baseline leptin concentrations were correlated positively with body mass index, waist-to-hip ratio, insulin, and HOMA-IR and negatively with ghrelin. After controlling for body mass index and waist-to-hip ratio in a partial correlation analysis, leptin levels were not correlated with these parameters. Ghrelin was inversely correlated with body mass index, waist-to-hip ratio, insulin, HOMA-IR, and free T. Conclusion(s): In patients with PCOS, an oral contraceptive containing ethinyl estradiol and drospirenone increases ghrelin levels but not leptin levels in a 3-month period. Ghrelin might be related to the metabolic and androgenic changes in patients with PCOS. (Fertil Steril (R) 2009;92:660-6. (C)2009 by American Society for Reproductive Medicine.)
  • [ X ]
    Öğe
    Serum kisspeptin, leptin, neuropeptide Y, and neurokinin B levels in adolescents with polycystic ovary syndrome
    (Walter De Gruyter Gmbh, 2022) Guzelkas, Ismail; Orbak, Zerrin; Doneray, Hakan; Ozturk, Nurinnisa; Sagsoz, Nevin
    Objectives Polycystic ovary syndrome (PCOS) is characterized by ovarian dysfunction, clinical and/or biochemical hyperandrogenism, and polycystic ovaries. Its pathogenesis is still unclear. This study aimed to investigate the relationship between kisspeptin, leptin, neuropeptide Y (NPY), and neurokinin B (NKB) levels for evaluating the pathogenesis of PCOS. Methods Levels of these parameters were analyzed in 20 patients with PCOS, and 16 healthy adolescents. Results Serum NPY levels were significantly higher in the obese and non-obese PCOS group (p<0.01). There was a negative correlation between the kisspeptin and the NKB levels (p<0.01) in the PCOS group but not in the control group. This negative correlation was also found in both PCOS groups (p<0.01). In the obese PCOS group, serum kisspeptin levels were significantly lower than the control and non-obese PCOS groups (p<0.05) although serum leptin and NPY levels were significantly higher in the obese PCOS group (p<0.01). Conclusions The high NPY levels in both obese and non-obese patients with PCOS indicate that NPY plays a role in the pathogenesis independently from obesity. Significantly high leptin and low kisspeptin levels in the obese PCOS group suggested that they may be associated with obesity rather than PCOS.