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Öğe The correlation between aqueous and serum level of Apolipoprotein A1 and B and diabetic retinopathy(Wichtig Publ, 2015) Timur, I. E. E.; Ornek, K.; Caglayan, O.…Öğe Letter to the editor, in response to the letter entitled: Mean platelet volume in retinal vein occlusions?(Verduci Publisher, 2014) Ornek, K.…Öğe Mean platelet volume in retinal vein occlusion(Verduci Publisher, 2014) Ornek, N.; Ogurel, T.; Ornek, K.; Onaran, Z.OBJECTIVE: The exact pathogenic mechanism underlying the thrombotic tendency in retinal vein occlusion (RVO) is still not fully established. We investigated relationship between platelet indices including mean platelet volume (MPV) and platelet count in RVO patients compared to control group. PATIENTS AND METHODS: Forty six patients (19 female, 27 male) diagnosed as RVO were included in the study. Forty-six subjects (26 female, 20 male) served as controls. Patients were evaluated by careful biomicroscopic examination using a fundus contact lens and fluorescein angiography. Blood samples for total blood count with MPV were obtained after overnight fasting from the antecubital vein. RESULTS: The mean platelet volume was 8.11 +/- 1.15 fl in RVO group. It was 8.68 +/- 0.98 fl in controls. When compared, the mean MPV was significantly lower in RVO patients (p < 0.05). The mean platelet volume was also significantly lower in branch retinal vein occlusion group in comparison to controls (7.92 +/- 1.19 fl. versus 8.68 +/- 0.98 fl.) (p < 0.05). CONCLUSIONS: MPV was significantly lower in patients with RVO than control group. MPV does not seem to be a potentially useful biomarker for prediction of RVO.Öğe Mini mental state exam versus Montreal cognitive assessment in patients with age-related macular degeneration(Verduci Publisher, 2014) Dag, E.; Otrnek, N.; Ornek, K.; Gunay, F.; Turkel, Y.OBJECTIVE: To compare the ability of the MMSE and MoCA to identify cognitive dysfunction in patients with age-related macular degeneration (AMD). PATIENTS AND METHODS: The study included 81 (29 female, 52 male) AMD patients who were recruited from the Ophthalmology Department of Kirikkale University during 2012. Participants were screened for cognitive impairment using the MMSE and MoCA. The scores were recorded for all participants. The primary outcome measure was the proportion of patients with a score less than 21 on either test. RESULTS: The percentage of subjects who scored below a cut off of 21/30 was higher on the MoCA (48.1%) than on the MMSE (18.5%) (p = 0.05). The range and standard deviation of scores was larger with the MoCA (7-30, 5.34) than with the MMSE (19-30, 3.26). There was a more pronounced ceiling effect of the MMSE than of the MoCA. The mean MMSE scores of dry-and wet-type AMD patients was significantly higher than the MoCA scores of the same patients (p = 0.000 and p = 0.000). CONCLUSIONS: The MoCA seems to be more sensitive than the MMSE to early cognitive impairment in AMD patients.Öğe Retinal nerve fiber layer thickness in congenital color vision deficiency(Sage Publications Ltd, 2008) Taner, P. Yilmazbas; Onaran, Z.; Ornek, K.; Gullu, R.PURPOSE. To evaluate the thickness of the retinal nerve fiber layer (RNFL) in subjects with congenital red-green color vision deficiency (CVD). METHODS. This study included 20 healthy subjects with congenital red-green CVD and 22 healthy subjects with normal color vision. After Ishihara test and examinations visual field by automated perimetry, all individuals underwent scanning laser polarimetry to measure the thickness of the RNFL. RESULTS. All scanning laser polarimetry parameters related to RNFL thickness were found to be similar in subjects with congenital CVD and normal color vision (p > 0.05). CONCLUSIONS. This is the first report suggesting normal thickness of the RNFL in subjects with congenital red-green CVD. (Eur J Ophthalmol 2008; 18: 845-7)Öğe Retinal nerve fiber layer thickness in the acute phase of sildenafil treatment(Verduci Publisher, 2015) Ornek, K.; Tuglu, D.; Ogurel, R.; Ornek, N.; Yilmaz, E.; Batislam, E.OBJECTIVE: To evaluate the early effect of sildenafil on the retinal nerve fiber layer (RNFL) thickness. PATIENTS AND METHODS: Sixty eyes of 60 patients were enrolled in the study. The patients underwent RNFL analysis by scanning laser polarimetry (Nerve Fiber Analyzer, GDx VCC: 5.3.3; Laser Diagnostic Technologies, San Diego, CA, USA) before and after a single 100 mg dose of sildenafil. Sixty eyes of 60 volunteers of similar age and sex distribution were taken as the control group. The RNFL thickness parameters evaluated included temporal, superior, nasal, inferior, temporal (TSNIT) average, superior average (SA), inferior average (IA), TSNIT standard deviation (SD), and nerve fiber index (NFI). RESULTS: The mean age of the patients was 53,52 +/- 9,26 years. The mean pre- and post-treatment TSNIT, SA, IA, TSNIT SD, and NFI of the patients were 57.46 +/- 4.94 mu versus 56.90 +/- 4.59 microns (mu), 68.93 +/- 6,12 mu versus 67,79 +/- 5,49 mu, 66,71 +/- 7.10 mu versus 66.31 +/- 6.82 mu, 24 +/- 3.86 mu versus 23.40 +/- 4.05 mu, and 16.50 +/- 6.08 mu versus 14.92 +/- 6.76 mu, respectively. There were no statistically significant differences between pre- and post-treatment RNFL thicknesses (p = 0.527, p = 0.281, p = 0.754, p = 0.416, p = 0.185, respectively). CONCLUSIONS: A single 100 mg dose of sildenafil seems to have no unfavorable effect on RNFL thickness in the acute phase of treatment.
