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    Association of physical activity and obesity status for individuals between the ages of 18-30 via bioelectrical impedance analysis device and metabolic holter measurements
    (Mattioli 1885, 2017) Aksoy, Aziz; Selen, Halime; Ozdemir, Fethi Ahmet; Arikan, Funda Bulut
    Obesity, according to its simplest definition, is excessive accumulation of fat in the body. Obesity is a health problem that is observed commonly in almost all societies and it is starting to become a global epidemic. In this study, physical activity and obesity statuses for individuals between the ages of 18-30 with different body types were tried to be associated via bioelectrical impedance analysis device and metabolic holter measurements. It was determined according to the results of the study that body fat ratio increases and number of steps decreases with increasing age, that there are statistically significant differences between gender and AEC, TEC, muscle weight and total body water and that this ratio is greater in men in comparison with women. Statistically significant differences (P<0.05) were determined between the muscle weight and total body water, BMI,waist/hip ratio, TEC, AEC; between total body water and BMI, waist/hip ratio, TEC and AEC; between the body mass index of individuals and their body fat ratio, waist/hip ratio, TEC and AEC; between body fat ratio and waist/hip ratio and TEC; betwen waist/hip ratio and TEC and BMR; total energy consumption and physical activity duration, AEC, number of steps, PAL, time spent with moderate intensity movement and time spent with very high intensity movement; physical activity levels and AEC, number of steps, PAL, time spent with moderate intensity movement and time spent with high intensity movement; between active energy consumption and number of steps, PAL, time spent with moderate intensity movement, time spent with high intensity movement and time spent with very high intensity movement; number of steps and PAL, time spent with moderate intensity movement, time spent with high intensity movement and time spent with very high intensity movement; PAL values of individuals who participated in the study and the time spent with moderate intensity movement, time spent with high intensity movement and time spent with very high intensity movement.
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    Protein Tyrosine Phosphatase Non-receptor 22 Gene C1858T Polymorphism in Patients with Coexistent Type 2 Diabetes and Hashimoto's Thyroiditis
    (Galenos Yayincilik, 2014) Bulut, Funda; Erol, Deniz; Elyas, Halit; Dogan, Halil; Ozdemir, Fethi Ahmet; Keskin, Lezan
    Background: A protein tyrosine phosphatase non-receptor type 22 (PTPN22) C1858T gene polymorphism has been reported to be associated with both Type 2 diabetes mellitus (T2DM) and Hashimoto's thyroiditis (HT) separately. However, no study has been conducted to explore the C1858T polymorphism in T2DM and HT coexistent cases up to now. Aims: The study aimed to determine whether a relationship exists or not between the PTPN22 C1858T polymorphism and this coexistent patient group. Study Design: Case-control study. Methods: Peripheral blood samples from 135 T2DM patients, 102 patients with coexistent T2DM+HT, 71 HT patients and 135 healthy controls were collected into ethylenediaminetetraacetic acid (EDTA) anticoagulant tubes and genomic DNA was extracted. The PTPN22 C1858T polymorphism was analyzed using polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) methods. Results: Statistically significant differences were not observed between the patient and control groups. This study demonstrated a statistically significant association between both the CT genotype and the T allele in the female patient group with coexistent T2DM+HT (CT genotype: p=0.04; T allele: p=0.045) with a statistically significant association between the CT genotype and the mean values of body mass index (BMI) and free T3 levels (FT3) (BMI: p=0.044 and FT3: p=0.021) that was detected in the patient group with coexistent T2DM+HT. The minor genotype TT was observed in none of the groups in this study. The CT genotype frequency was [number (frequency): 5 (3.8%), 7 (6.86%), 5 (7.04%), 3 (2.22%), while the T allele frequency was 5 (1.86%), 7 (3.44%), 5 (3.53%) and 3 (1.12%)] in the T2DM, T2DM+HT, HT and control groups, respectively. Conclusion: Our data suggest that the PTPN22 1858T allele and the CT genotype are associated with increased risk in female patients for coexistent T2DM+HT. The CT genotype was associated with high mean BMI and free T3 values in the patient group with coexistent T2DM+HT. These results demonstrate that T allele carriers were more often in the T2DM+HT group than in the T2DM group. Therefore, the combination of T2DM and HT with female gender may have higher T allele carriage in comparison to the T2DM only and male groups.
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    Vitamin A And E Levels In Patients With Chronic Kidney Disease
    (Parlar Scientific Publications (P S P), 2018) Aksoy, Aziz; Gozel, Nevzat; Bulut-Arikan, Funda; Kucuksu, Mehmet; Ozdemir, Fethi Ahmet
    Chronic kidney disease (CKD) is a disease that manifests itself with abnormalities in kidney structure or function. Inflammation and oxidative stress increase in kidney disease in parallel with the advancement of the disease. In addition, vitamin synthesis metabolism is also disrupted as a result of the decrease in kidney functions. Vitamins A and E are strong anti-inflammatories and antioxidants which protect the body against oxidative stress. Hence, the activation of these vitamins in CKD patients is of significant importance. The study was carried out with the participation of 139 people comprised of 79 volunteer patients diagnosed with Stage-5 CKD and 60 healthy volunteers (control). Demographic measurements of the participants were carried out and their biochemical parameters (glucose, urea, creatinin, AST, ALT, and LDL etc.) were determined via ELISA and spectrophotometric analyses. Serum A and E vitamin levels were determined via HPLC analysis. No statistically significant difference was determined (p=0,56) in this study between the groups even though the vitamin A level of the patient group was lower, while vitamin E levels were determined to be lower at a statistically significant level in the patient group in comparison with the control group (about half) (p=0,000).Statistically significant differences were determined between the patient and control groups when; BMI, glucose, urea, creatinin, AST, ALT, LDL, triglyceride, HDL, albumin, hemoglobin, platelet, RBC, HCT, MCH and Diastolic blood pressure averages were compared (p > 0,005). A positive and statistically significant correlation was determined in the patient group between Vitamin A and E and urea (r=0,325 p=0,003; r=0,278, p=0.013). The decrease in vitamins A and E levels in CKD may be increasing oxidative stress and inflammation in these patients. It can be concluded as a result of this study that a low dose of vitamin A and a strong dose of vitamin E work as strong antioxidants in chronic kidney disease as strong antioxidant and anti-inflammatory molecule.