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Öğe Dispiro-4-bromobenzylaminophosphazenes: Synthesis reactions, spectroscopic and chromatographic properties, crystal structures, biological, and cytotoxic activities(Amer Chemical Soc, 2019) Kuzey, Nur Guven; Ozgur, Mehtap; Asmafiliz, Nuran; Acik, Leyla; Aydin, Betul; Hokelek, Tuncer; Cerci, Aytuna…Öğe Dispiro-4-bromobenzylaminophosphazenes: Synthesize reactions, spectroscopic properties, crystal structures, biological and cytotoxic activities(Amer Chemical Soc, 2019) Kuzey, Nur Guven; Ozgur, Mehtap; Asmafiliz, Nuran; Acik, Leyla; Aydin, Betul; Hokelek, Tuncer; Cerci, Nebahat Aytuna…Öğe Phosphorus-nitrogen compounds: Part 46. The reactions of N3P3Cl6 with bidentate and monodentate ligands: The syntheses, structural characterizations, antimicrobial and cytotoxic activities, and DNA interactions of (N/N)spirocyclotriphosphazenes with 4-chlorobenzyl pendant arm(Elsevier Science Sa, 2019) Asmafiliz, Nuran; Berberoglu, Ipek; Ozgur, Mehtap; Kilic, Zeynel; Kayalak, Hande; Acik, Leyla; Hokelek, TuncerIn the present study, the partly and fully-substituted monospiro (4-6, 4a-6d), cis-dispiro (7-9), trans-dispiro (10-15) cyclotriphosphazenes were synthesized for the investigations of their chemical, stereogenic and biological properties. The cis/trans phosphazenes (7-12) have two stereogenic P centers. They are expected to be in meso and racemic forms. In addition, the structures of four compounds were evaluated using X-ray crystal-lographic data. Compound 13 was found to be a single enantiomer (RR) in the solid state, as also proved with its CD spectrum. The antibacterial and antifungal activities of the phosphazenes were elucidated for against Gram-positive (G+) and Gram-negative (G-) bacteria, and yeast strains, respectively. Of the compounds, 14 exhibits strong antimicrobial activity against most of the tested organisms, especially B. cereus and E. hirae. MBC and MFC values of compounds on different bacterial and fungal species ranged from < 9.8 mu M to 2500 mu M. Furthermore, the cytotoxic activities of 6, 4c, 10 and 14 were investigated against L929 fibroblast and DLD-1 cells, and 14 was the most cytotoxic compound against DLD-1.
