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    Expression of glutathione-S-transferases isoenzymes and p53 in exfoliated human bladder cancer cells
    (Elsevier Science Inc, 2011) Oguztuzun, Serpil; Sezgin, Yasemin; Yazici, Sertac; Firat, Pinar; Ozhavzali, Muzeyyen; Ozen, Haluk
    Objectives: This study investigates the usefulness of glutathione-S-transferases (GST) isoenzymes and p53 immunostaining as a marker of malignancy in urinary cytology, and evaluates their potential effect in increasing diagnostic accuracy in a series of urine cytologic samples. They are also correlated with cytopathology diagnosis and histopathologic diagnosis. Materials and methods: In this study, the slides from 124 bladder carcinoma patients prepared by the cytocentrifugation method were observed. The cytomorphologic properties of these cancer cells were determined. Moreover, the immunocytochemical distributions of GST alpha (GSTA), pi (GSTP), mu (GSTM4), theta (GSTT1) isoenzymes and p53 protein were studied for the patients. Results: The urothelial cancer cells had small cytoplasm and rough nuclear membrane. The chromatin granules were heterogeneously distributed in each malignant cell's nucleus. There was a pleomorphism of the malignant cells' nuclei. According to immunocytopathologic observations, the urothelial cancer cells had stronger staining intensity than the benign cells had in 48% of cases for GSTA, 46% of cases for GSTP, 38% of cases for GSTM4, and 42% of cases for GSTT1. For all papillary cases, the malignant cells were stained negative, while the benign cells were positive. For 83% of patients, the malignant cells were stained positive for p53. There was a significant difference in GSTA (P = 0.006), GSTT1 (P = 0.004), GSTP (P = 0.000) and p53 (P = 0.000) expressions for benign cells whereas, a non-statistical difference in the malignant cells for GSTA, GSTT1, GSTP, GSTM4, and p53 expressions (P > 0.05). Conclusions: GST isoenzymes and p53 immunostaining were not found to be markers of malignancy in urinary cytology. (C) 2011 Elsevier Inc. All rights reserved.
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    The expression of GST isoenzymes and p53 in non-small cell lung cancer
    (Via Medica, 2010) Oguztuzun, Serpil; Aydin, Mehtap; Demirag, Funda; Yazici, Ulku; Ozhavzali, Muzeyyen; Kilic, Murat; Iscan, Mesude
    This study investigated the immunohistochemical staining characteristics of glutathione-S-transferase alpha, pi, mu, theta and p53 in non-small cell lung carcinoma and normal lung tissue from 50 patients. The relationships between expressions of the Glutathione-S-transferase isoenzymes and some clinicopathological features were also examined. Expression of glutathione-S-transferase pi, mu, alpha, theta and p53 was assessed by immunohistochemistry for primary lung carcinomas of 50 patients from the Sanitarium Education and Research Hospital, Ankara lung cancer collection. The relationships between expression of the glutathione-S-transferase isoenzymes, p53 in normal and tumor tissue by Student T test and the clinicopathological data were also examined by Spearman Rank tests. When the normal and tumor tissue of these cases were compared according to their staining intensity and percentage of positive staining, glutathione-S-transferase alpha, pi, mu, theta expressions in tumor cells was significantly higher than normal cells (p<0.05). There was no significant difference in the expression of p53 between normal and tumor cells (p>0.05). When the immunohistochemical results of glutathione-S-transferase isoenzymes and p53 were correlated with the clinical parameters, there were no significant associations between glutathione-S-transferases and p53 expressions and tumor stage, tumor grade and smoking status (p>0.05).
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    On Approximation Properties of Two Variables of Modified Kantorovich-Type Operators
    (Ankara Univ, Fac Sci, 2019) Ozhavzali, Muzeyyen; Olgun, Ali
    In the present paper, we introduce certain modification of Szasz-Mirakyan-Kantorovich-type operators in polynomial weighted spaces of continuous functions of two variables. Then we research some approximation properties of these operators. We give some inequalities for the operators by means of the weighted modulus of continuity and also obtain a Voronovskaya-type theorem. Furthermore, in the paper we show that our operators give better degree of approximation of functions belonging to weighted spaces than classical Szasz-Mirakyan operators.