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    Left atrial function index and left atrial electromechanical functions in anxiety disorders
    (Taylor & Francis Ltd, 2024) Ozturk, Hayriye Mihrimah; Erdogan, Mehmet; Turan, Yasar; Celik, Ibrahim Etem; Ozturk, Selcuk
    BackgroundThere is a close linkage between anxiety disorders (ADs), and development of cardiovascular disease (CVD) and atrial fibrillation (AF). We aimed to investigate left atrial function index (LAFI) and its components, LA mechanical functions and atrial conduction times in AD patients and age- and gender-matched control group patients for the first time in the literature.MethodsA total of 48 AD patients and 33 healthy subjects were enrolled to the study prospectively. Echocardiographic parameters including two-dimensional conventional echocardiography, diastolic functions, LA mechanical functions, LAFI, atrial conduction times and atrial electromechanical delay (AEMD) were calculated.ResultsThe velocity-time integral of the LV outflow tract (LVOT-VTI), LAFI and LA conduit volume were significantly lower in AD patients. Atrial electromechanical coupling as established from lateral mitral annulus (PA lateral) was significantly higher in AD group than control group. Inter-AEMD and left intra-AEMD were also higher in AD group compared to control group. Age, gender, body surface area (BSA), conduit volume, LVOT-VTI and LAFI were significant factors associated with AD in univariate analysis. However, only BSA and LVOT-VTI (Odds ratio [OR]: 0.79, 95 CI%: 0.66-0.95, p = 0.013) were independently associated with AD in multivariate analysis. Age, gender, conduit volume and LAFI (OR: 0.25, 95 CI%: 0.03-2.12, p = 0.204) were not found to be independent associates of AD.ConclusionLAFI is impaired in patients suffering from AD compared to their age- and gender-matched counterparts but this impairment originates from lower levels of LVOT-VTI calculations in AD patients. Thus, LVOT-VTI, but not LAFI, is independently associated with AD.
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    Reply to Letter to the Editor: Factors Influencing the Risk of No-Reflow Development
    (Kare Publ, 2024) Celik, Ibrahim Etem; Yarlioglu, Mikail; Barutcu, Ozan; Akgun, Onur; Duran, Mustafa; Yorulmaz, Suekrue; Ozturk, Selcuk
    [Abstract No tAvailable]
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    The Association Between Atherogenic Index of Plasma and No-Reflow Phenomenon in Acute Coronary Syndrome
    (Kare Publ, 2023) Celik, Ibrahim Etem; Ozturk, Selcuk; Yarlioglu, Mikail; Barutcu, Ozan; Akgun, Onur; Duran, Mustafa; Yorulmaz, Sukru
    Background: The atherogenic index of plasma (AIP) is a biomarker of plasma atherogenicity. Elevated AIP is linked with adverse cardiac events. We sought to examine the association of admission AIP and no-reflow phenomenon (NRP) in acute coronary syndrome (ACS) patient population treated with percutaneous coronary intervention (PCI).Methods: Eight hundred eight-four ACS patients were included to statistical tests retrospectively and classified according to the occurrence of NRP: NRP (-) (n = 662) and NRP (+) (n = 186). AIP levels were calculated through the formula log10 (trig lycer ide-t o-hig h-den sity lipoprotein cholesterol ratio).Results: AIP levels were higher in NRP (+) patients compared to NRP (-) group patients. The receiver operating characteristic (ROC) curve analysis for AIP to predict NRP yielded an area under the ROC curve value 0.643 [95% confidence interval (CI): 0.596-0.690, P < .001]. AIP was associated with NRP in univariate logistic regression analysis [Odds Ratio (OR): 2.46; P = .001; CI: 1.44 (lower limit)-4.21 (upper limit)]. However, AIP did not emerge as a significant prognostic factor of NRP in multiple logistic regression analysis [OR: 2.11; P = .422; CI: 0.34 (lower limit)-13.11 (upper limit)]. On the other hand, peak troponin T (log10) was an independent prognostic factor for NRP [OR: 0.13; P < .001; CI: 0.10 (lower limit)-0.37 (upper limit)] occurrence.Conclusion: The AIP level on admission is not a statistically significant prognostic factor of NRP. However, peak troponin T (log10) is an independent prognostic parameter of NRP.
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    The association between total cholesterol and cognitive impairment in chronic obstructive pulmonary disease patients
    (Elsevier Science Inc, 2023) Ozturk, Hayriye Mihrimah; Ogan, Nalan; Erdogan, Mehmet; Akpinar, Evrim Eylem; Ilgar, Ceren; Ozturk, Selcuk
    Aim: Chronic obstructive pulmonary disease (COPD) is primarily a respiratory system disorder associated with extrapulmonary conditions. Cognitive impairment (CoI) is very common among COPD patients This study sought to investigate the association between CoI and clinical parameters, inflammatory markers and lipid profiles in a COPD patient population.Methods: The study population included 111 stable COPD patients. COPD was diagnosed according to Global Initiative for Chronic Obstructive Lung Disease guideline. Total complete blood count test and biochemical measurements including lipid profile were performed. Afterwards, all patients underwent neuropsychological assessment including Hospital Anxiety and Depression Scale (HADS), Pittsburgh Sleep Quality Index and Mon-treal Cognitive Assessment (MoCA) tests.Results: The patients were categorized into two groups according to their MoCA test score: MoCA score & LE; 21 (CoI) (n = 69) and MoCA score > 21 (normal cognition) (n = 42). Total cholesterol (TC) levels were significantly lower in patients with CoI compared to patients with normal cognition. Inflammation related parameters including C -reactive protein were similar among groups. Multivariate logistic regression analysis yielded education, HADS score and TC (OR:1.02, 95% CI:1.00-1.04, p = 0.025) as independent predictors of MoCA score.Conclusion: TC independently associates with CoI in COPD patients. There is comparable inflammatory status in COPD patients with CoI compared to COPD patients with normal cognition.
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    Traditional and nontraditional lipid parameters in Helicobacter pylori infection
    (Taylor & Francis Ltd, 2024) Ozturk, Selcuk; Dursun, Muhammed A.; Yildirim, Tekin; Sargin, Fatih; Sargin, Zeynep G.; Ozan, Zeynep T.
    Aims: This study sought to evaluate the relationship between Helicobacter pylori infection and traditional and nontraditional lipid parameters, including atherogenic index of plasma, cardiogenic risk ratio, atherogenic coefficient and remnant cholesterol. Methods: After the application of exclusion criteria, 309 patients were allocated according to the absence (n = 52) or presence (n = 257) of H. pylori infection. Results: Total cholesterol, low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) levels were nonsignificantly higher, and HDL-C levels were nonsignificantly lower, in the H. pylori-infected patient group. Triglyceride-to-HDL-C ratio, LDL-C-to-HDL-C ratio, atherogenic index of plasma, cardiogenic risk ratio, atherogenic coefficient and remnant cholesterol were comparable among groups. Conclusion: There was no significant association between H. pylori infection and traditional and nontraditional novel lipid parameters and indices.