Yazar "Poyraz, Merve" seçeneğine göre listele
Listeleniyor 1 - 10 / 10
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe A Rare Presentation of Coeliac Disease; Intractable Itching with Recurrent Heart Attack and Dermatitis Herpetiformis(Bilimsel Tip Yayinevi, 2021) Alan Yalim, Sumeyra; Dumanoglu, Betul; Poyraz, Merve; Alpagat, Gulistan; Baccioglu, Ayse; Kalpaklioglu, Ayse FusunCoeliac disease (CD) is a systemic disease of the unwarranted immune reaction to gluten and is associated with a 10% increased risk of cardiovascular disease. Here we present a patient with recurrent myocardial ischemia and intractable itching who was eventually diagnosed with CD. A 53-year-old man presented to the allergy department due to intractable itching that was resistant to antihistamine therapy. In addition, despite successful percutaneous intervention with stent implantation to the right coronary artery, there was an ST segment elevation with myocardial infarction (MI) in the lower wall that had occurred three times. After dermatitis herpetiformis was reported as a result of the biopsy performed from the lesions, duodenal biopsy confirmed the diagnosis of CD. Diagnosis of CD with atypical presentation can be difficult. Cardiovascular risk is increased in patients with celiac disease compared to the normal population. Itching is an important symptom that needs to be evaluated in detail, even without the typical gastrointestinal manifestations of CD.Öğe Allergic Contact Dermatitis due to Medical Mask; A Case Report(BILIMSEL TIP YAYINEVI, 2020) Alpagat, Gulistan; Dumanoglu, Betul; Poyraz, Merve; Alan Yalim, Sumeyra; Baccioglu, Ayse; Kalpaklioglu, Ayse FusunAllergic contact dermatitis occurs as a result of delayed hypersensitivity reaction caused by various exogenous substances. Here, a case of allergic contact dermatitis due to medical mask use is presented. A 39-year-old female patient was admitted to Allergy outpatient clinic with complaints of red and itchy maculopapular lesions, and small blisters on the cheeks, nasolabial folds, chin and neck under the chin that started three days ago. She had no chronic illness, massive sunshine exposure, history of systemic and topical medication intake and cosmetic use. The patient has been using washable masks for the whole COVID-19 pandemic period, however she used medical masks instead of washable ones 15 days ago once and for the last two days before the beginning of her complaints. Even though there was no reaction in her first contact, the above dermatitis lesions restricted to mask area developed 24-48 hrs after starting to use it for the second time. Allergic contact dermatitis was diagnosed due to skin lesions suitable with dermatitis and occurrence of the reaction after the second contact to a suspicious substance. She was recommended to stop using medical masks, and a treatment of oral antihistamine and topical steroid was prescribed. After her complaints resolved completely, a challenge with a different brand of medical mask was performed, and no reaction was observed. As a result, this case implicates that allergic contact dermatitis may occur due to using medical masks, and it is important to use masks with standardized approval since they are essential in preventing airborne infections including corona virus.Öğe Anaphylaxis After Consumption of Guar Gum-Containing Food: A Report of Two Cases(Springernature, 2022) Dumanoglu, Betul; Alpagat, Gulistan; Poyraz, Merve; Yalim, Sumeyra Alan; Baccioglu, AyseGuar gum is a food additive that acts as a thickening agent. Although the relationship between guar gum and occupational rhinitis/asthma has already been established, only very few cases of anaphylaxis were associated with guar gum ingestion. We present two examples of anaphylaxis induced by guar gum. Both cases were successfully treated with adrenaline. Moreover, serum-specific immunoglobulin E (IgE) with the culprit agent was detected in blood samples. To the best of our knowledge, here we present the first case of class 6 guar gum-specific IgE-positive anaphylaxis. This report aims to raise awareness of rare food additive allergies such as guar gum.Öğe Characteristics of Adverse Reactions and Compliance in Patients who Underwent Allergen-Specific Subcutaneous Immunotherapy; Ten-Year Real-Life Data(Bilimsel Tip Yayinevi, 2022) Baççıoğlu, Ayşe; Kalpaklıoğlu, Ayşe Füsun; Poyraz, Merve; Alan Yalım, Sümeyra; Dumanoğlu, Betül; Alpagat, GülistanObjective: Allergen-specific subcutaneous immunotherapy (SCIT) is known as the best therapeutic method that may alter the natural course of allergic diseases, compared to pharmacological and avoidance options. However, some problems such as adverse reactions (ARs), inconvenience, and high costs of a prolonged course of therapy may prevent patients from completing the therapy. The objective of this study was to evaluate the evidence for the potential barriers against the benefits of SCIT in adult patients. Materials and Methods: An observational study between 2009 and 2019 was performed at the Allergy Clinic of a tertiary hospital. The data of 166 adult patients who underwent SCIT for allergic rhino-conjunctivitis (ARC), and/or asthma or hymenoptera venom anaphylaxis using conventional schedules with standard allergen extracts were evaluated. Results: SCIT indications were ARC (63%), ARC and asthma (19.3%), and venom anaphylaxis (17.5%). The standardized allergen extracts used were grass pollen (59%), house dust mite (19.9%), and hymenoptera venom (17.5%). The frequency of SCIT-related ARs was 7.4% per injection, and 42.2% per patient. Local ARs were more frequent than systemic ARs (SAR)s. The majority of the SARs were composed of anaphylaxis and generalized urticaria, which were mostly of moderate severity with no deaths. SARs were more common in women, in patients with high injection numbers, and in patients under SCIT with cat allergen or multiple allergens. Most of the SARs occurred immediately after injection, and in the initial phase, whereas the delayed-type of SARs was common in patients with pollen SCIT. Three patients under cat SCIT discontinued treatment due to SARs of immediate and moderate/severe type. Ratios of SARs of venoms were insignificantly higher than aeroallergens. SARs with house dust mite SCIT were rare. Rates of patients' compliance to SCIT were similar between the allergen extracts, with an average of 70%. The most common causes of non-compliance were non-adherence, leaving the current residence, difficulty in obtaining the allergen extracts, and ARs. The frequencies of local and moderate ARs were higher in compliant patients, whereas systemic and severe ARs were higher in non-compliant ones. In the regression model, it was found that ARs increased and patient compliance decreased as the number of injections increased. Conclusion: This study in the real-life setting for a decade showed that less than half of the patients that underwent SCIT had developed ARs, which were generally local and of moderate severity. In conclusion, these results indicated that each allergen of SCIT had different characteristics of ARs, and the moderate incidence of ARs was not a problem regarding compliance with SCIT. Therefore, SCIT may be preferred in indications of allergy, and has a tolerable balance of ARs and safety.Öğe Evaluation of systemic inflammation markers in patients with rhinitis(Springer Heidelberg, 2024) Yalim, Suemeyra Alan; Kalpaklioglu, Ayse Fuesun; Baccioglu, Ayse; Poyraz, Merve; Alpagat, Gulistan; Dumanoglu, BetulBackground: Rhinitis affects the majority of the population. It may generate localized nasal mucosal inflammation via allergic (AR) or nonallergic (NAR) processes, but it is unknown if this might also result in systemic inflammation, which can raise morbidity and death. Using current serum inflammatory markers, we sought to investigate systemic inflammation in patients with chronic rhinitis. Methods: In this retrospective case-control study, we included 439 patients with newly diagnosed AR (n = 179), NAR (n = 157), and 103 healthy individuals. Inflammation-related blood parameters were collected as lymphocyte/monocyte ratio (LMR), neutrophil/lymphocyte ratio (NLR), eosinophil/neutrophil ratio (ELR), and systemic immune inflammation index (SII). Results: All groups were similar in terms of age, gender, and body mass index. Neutrophil counts were significantly higher both in AR and NAR groups compared to controls (4.51 +/- 0.09, 4.54 +/- 0.1 vs. 3.73 +/- 0.1, p < 0.001). NLR (1.91 +/- 0.56, 1.89 +/- 0.61, 1.61 +/- 0.59, p < 0.001), LMR (5.76 +/- 0.17, 5.93 +/- 0.17, 5.1 +/- 0.15, p = 0.005), ELR (0.1335 +/- 0.007, 0.0999 +/- 0.006, 0.12 +/- 0.009, p = 0.003), SII (533.3 +/- 16.6, 558.1 +/- 20.9, 479.9 +/- 22.2, p = 0.035), and CRP (1.44 +/- 0.09, 1.67 +/- 0.09, 0.87 +/- 0.04, p < 0.001) were significantly higher in AR and NAR groups than the controls, respectively. SII (r = 0.146, p = 0.007) and ELR (r = 0.254, p < 0.001) were correlated with the presence of asthma. Conclusion: We found that systemic circulation of inflammatory cells was significantly increased in rhinitis with/without allergy compared to the control group. This study showed that not only AR, but also NAR triggers a systemic increase of inflammation which supports the link between rhinitis and comorbid conditions such as asthma. Therefore, effective treatment may be suggested for local inflammation and its systemic manifestations.Öğe Hypereosinophilia of undetermined significance in a rheumatoid arthritis patient(Wiley, 2022) Dumanoglu, Betul; Alpagat, Gulistan; Poyraz, Merve; Baccioglu, Ayse; Kalpaklioglu, Ayse Fusun[Abstract No tAvailable]Öğe Rare Interstitial Pneumonia Due to the Use of Aripiprazol: A Case Report(2022) Alpagat, Gulistan; Baccıoğlu, Ayse; Yalim, Sumeyra Alan; Poyraz, Merve; Dumanoğlu, Betul; Kalpaklıoğlu, Ayse FusunIt is accepted that 2–3% of interstitial lung diseases (ILD) are due to drugs, and that 70% of drug-induced lung diseases are due to ILD. We present here the case of a 51-year-old female patient who had been taking aripiprazole for bipolar disorder for 3 years and had been undergoing asthma treatment for 2 years. ILD was considered based on the patient's clinic, a restrictive pattern in the pulmonary function test (PFT), a decreased carbon monoxide diffusion test, laboratory results, radiological findings and biopsy. The possible etiologies of infection, aspiration, heart failure, pet feeding status and exposure to haz-ardous respiratory substances were excluded. The suspected drug was discontinued and oral cortico-steroid treatment was started. Lung toxicity can devel-op with drug treatments, and so drug history should be questioned in detail and discontinued immediately in case of any doubt. ILD is rare, and if the drug is not suspected and continued, the disease may be-come chronic and progress to respiratory failure. We present this case to increase awareness of the disease.Öğe Starting as cold-induced anaphylaxis but following as urticaria(Wiley, 2022) Poyraz, Merve; Alpagat, Gulistan; Dumanoglu, Betul; Yalim, Sumeyra Alan; Baccioglu, Ayse; Kalpaklioglu, Ayse Fusun[Abstract No tAvailable]Öğe The Effect of Internet Addiction on Asthma Control and Medication Adherence(Bilimsel Tip Yayinevi, 2022) Kalpaklıoğlu, Ayşe Füsun; Baccıoğlu, Ayşe; Dumanoğlu, Betül; Poyraz, Merve; Yalım, Sümeyra Alan; Alpagat, GülistanObjective: Internet addiction has recently become a prevalent health problem. Although many studies indicate a link between internet addiction and various diseases, no studies have examined its consequences on asthma control or medication adherence. The purpose of this study was to determine how internet addiction affects asthma control and medication adherence. Materials and Methods: Study participants were grouped as asthmatics and healthy controls whom were aged between 18 and 77. Asthma control test (ACT) and medication adherence report scale (MARS-5) were fulfilled by asthma patients, whereas short version of Young Internet Addiction Test (s-IAT) was applied to all participants. Pulmonary function test was performed to all subjects. Results: Forty-nine healthy volunteers and 54 asthmatic subjects were enrolled. Age and gender profiles within the study groups were similar. There was no significant difference in means of problematic and pathological (s-IAT >= 31) s-IAT scores between asthma and control groups (24.1% and 20.4%, p=0.41), as well as between asthma patients with controlled and uncontrolled ACT scores (24.1% and 24%, p=0.99), and those with and without medication adherence (16.7% and 27.8%, p=0.50). s-IAT scores were found to be linked to higher educational level (p=0.01, r=0.37), and better FEV1 (p=0.04, r=0.27) in asthmatic patients. In addition, MARS-5 was correlated with older age (p=0.02, r=0.29), and low FEV1 (p=0.01, r= -0.35). Conclusion: Internet addiction did not seem to directly affect asthma control or medication adherence. However, it appeared to be associated with a high level of education and FEV1.Öğe Vitamin D Levels in Patients with Allergic and Non-Allergic Rhinitis(Bilimsel Tip Yayinevi, 2022) Kalpaklıoğlu, Ayşe Füsun; Alpagat, Gülistan; Baççıoğlu, Ayşe; Alan Yalim, Sümeyra; Dumanoğlu, Betül; Poyraz, MerveObjective: Allergic and non-allergic rhinitis are quite similar from a clinical viewpoint and allergen sensitivity seems to be the important relevant difference between them. However, the role of vitamin-D (vit-D) as an immunomodulator hormone and on rhinitis phenotypes is not clear. We aimed to investigate the relation between vit-D levels and patients with rhinitis as allergic (AR) and non- allergic (NAR). Materials and Methods: This was a retrospective research of 228 patients whom were diagnosed at a tertiary hospital between 2012 and 2016. Rhinitis was diagnosed as AR if nasal symptoms were accompanied with skin prick test (SPT) positivity, and NAR if they were relevant with negative SPT. The clinical history of the patients and the symptoms were recorded. Serum total IgE tests were performed using an allergen detection system (UniCAP, Phadia, Uppsala, Sweden), and vit-D levels were measured with the 25-hydroxy-vit-D (25-OH vit-D) kit in the Elecsys 2010 analyzer (Roche Diagnostics, Germany). Results: A total of 228 patients (AR=170 and NAR=58) with a mean age of 31.06 +/- 11.58 yrs were included. The mean age and ratio of female gender were significantly higher in NAR (p=0.03), whereas obesity was significantly higher in AR patients (p=0.01). Duration of rhinitis in NAR was longer than in AR (p=NS). Serum total IgE levels were significantly higher in AR than NAR, whereas mean levels and ratio of vit-D deficiency were similar between the groups. Levels of vit-D were significantly lower in females than males only in the AR group (p<0.001). Patients with NAR had mostly severe vit-D deficiency (<10 ng/mL), and those with AR had mostly non-severe vit-D deficiency (11-19 ng/mL). There was no relationship between vit-D deficiency and allergen sensitization, but there was a negative correlation of vit-D levels and female gender in the AR group (p<0.001). Conclusion: The present study showed no association between serum vit-D level and allergen sensitization in adult patients with allergic and nonallergic rhinitis.
