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Öğe Farkli yönleriyle NETosis(Refik Saydam National Public Health Agency (RSNPHA), 2017) Sürsal N.; Yildiz K.Autoimmune and autoinflammatory diseases have dramatically increased in both developed and developing countries. The etiology of these diseases is complex and developed due to multifactorial causes. It is tought that autoantigens are the basis of systemic autoimmune diseases in organism. Recent studies have revealed that NETosis can triggered some autoimmune and autoinflammatory diseases, so this defence mechanism has begun to attract great interest. A better understanding of this complex mechanism is believed to have a promising and critical prescription for the identification of new treatment modalities for these diseases with the development of important tools in the diagnosis of autoimmune diseases. In this review, information has been given on NETosis which is participate in some pathologies in the organism.Öğe Seroprevalence of Neospora caninum in Dairy Cattle Raised in Çiçekdaği District of Kırşehir Province(2017) Yıldız K.; Gökpınar S.; Sürsal N.; Değirmenci R.OBJECTIVE: Neospora caninum is one of the most important causes of abortion in cattle worldwide and causes significant economic losses in the meat and dairy industries. This study aimed to determine the seroprevalence of N. caninum in dairy cattle raised in Çiçekdağı district of Kırşehir province.METHODS: One hundred sixteen serum samples collected from dairy cattle were analyzed for N. caninum antibodies by a commercial Enzyme-Linked ImmunoSorbent Assay (ELISA) kit (VMRD c-ELISA).RESULTS: The seropositivity rate was 18.1% in the cattle examined. The seroprevalence of N. caninum was 23.4% in dairy cattle with fertility problems, 33.3% in cattle with a history of abortion, and 7.8% in clinically healthy dairy cattle (p=0.006). Cattle breeds with highest seropositivity rates were Holstein, Simmental, and Brown Swiss (p=0.008).CONCLUSION: Control measures should be taken for both dogs as final host of the parasite cattle to prevent the spread of neosporosis in cattle in Çiçekdağı district.