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    Effects of oral contraceptives with low-dose estrogen and desogestrel on leptin concentrations
    (Sci Printers & Publ Inc, 2002) Sagsöz, N.; Akcay, F.; Bayram, M.
    OBJECTIVE: To evaluate short-term leptin concentrations in women who use low-dose oral contraceptives. STUDY DESIGN: From 15 women without medical problems, venous blood samples were taken: basal, between days 3 and 5 of menstruation, and in the third month. The Human Leptin Radioimmunassay Kit (Linco Reseach, Inc., St. Charles, Missouri) was used for leptin measurement. Statistical analysis was done with the Wilcoxon test. RESULTS: The average patient age was 30.1 +/- 6.7 years. The basal leptin concentrations and leptin concentrations at the third month were 22.17 +/- 8.85 and 23.04 +/- 6.77 ng/mL, respectively. This increase was not statistically significant. CONCLUSION: Oral contraceptives with low-dose estrogen and desogestrel do not affect leptin concentrations in a three-month period.
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    Ischaemia-reperfusion injury of rat ovary and the effects of vitamin C, mannitol and verapamil
    (Oxford Univ Press, 2002) Sagsöz, N.; Kısa, Ü.; Apan, A.
    BACKGROUND: In this prospective controlled study, the aim was to examine the effects of vitamin C, mannitol and verapamil on adnexial ischaemia-reperfusion injury in the rat ovary. METHODS: Thirty-six female Wistar rats were used. In the controls (group 1), only laparotomy was performed. In group 2, ovarian ischaemia was produced and the bilateral ovaries were surgically removed 4 h later. In group 3, an ischaemic period of 4 h was followed by reperfusion for 1 h; the bilateral ovaries were then removed. In groups 4, 5 and 6, after 4 h of ischaemia, either vitamin C, mannitol or verapamil respectively was infused before reperfusion; after 1 h of reperfusion the ovaries were removed. Thiobarbituric acid reactive substance (TBARS) levels were measured in all ovary tissues. RESULTS: TBARS levels of the reperfusion group were significantly higher than those of groups treated with vitamin C or mannitol (P = 0.013 and P = 0.045 respectively), but not of the verapamil group. CONCLUSIONS: Vitamin C and mannitol were found to be effective in reducing ischaemia-reperfusion injury of the ovary during its early stages, but verapamil was ineffective.