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Öğe Association of body mass index and weight gain patterns with albumin excretion in pregnancy(Wiley, 2018) Tulmac, Ozlem B.; Dag, Zeynep O.; Erdogan, Funda; Sayan, Cemile D.; Sagsoz, NevinAimWe examined body mass index (BMI) and gestational weight gain (GWG) patterns of pregnant women and investigated the impact of these factors on the urinary albumin-creatinine ratio (ACR) during pregnancy. MethodsThe data of 163 women whose basal BMI and ACR were measured during the first trimester were used in this study. Body weight alone between 12-16 weeks and body weight together with ACR after 37 weeks of gestation were measured. ResultsOverall, 46% of women were overweight or obese, 60.7% had excessive weight gain and 16.6% had inadequate weight gain. Only 22.7% of women gained weight within the recommended range. There was no difference in weight gain patterns with respect to BMI. ACR during the third trimester was significantly higher than during the first trimester (7.08 [0.00-1180.90] mg/g vs 4.73 [0.00-275.00] mg/g, respectively; P = 0.001). The ACR of obese women was higher than in normal weight subjects during the third trimester (16.79mg/g [0.01-1180.90] vs 8.07mg/g [0.10-402.14] respectively; adjusted P = 0.015). Both ACR change and third trimester ACR were weakly but significantly correlated with basal BMI (r: 0.228 P: 0.003 and r: 0.301 P<0.001, respectively) but not with GWG or GWG rate. Basal BMI was not associated with first-trimester ACR. ConclusionObesity is associated with an increase in urinary albumin excretion during the course of pregnancy. Distinction of this relationship during pregnancy offers an opportunity for further research on pathophysiological mechanisms. The alarmingly high rate of non-compliance with IOM guidelines in pregnant women is a concern. Prompt measures for counseling of women before and during pregnancy in order to maintain healthy weight are needed.Öğe Attention-Deficit Hyperactivity disorder in adult primary dysmenorrhea patients(Ondokuz Mayis Universitesi, 2021) Sagsoz, Nevin; Oguzturk, Omer; Aktulum, FatmaThe aim of this study is to evaluate attention-deficit hyperactivity disorder in adult primary dysmenorrhea patients. 62 primary dysmenorrhea patients and 52 control group members are included in the study. Demographic characteristics such as education level and age were noted. Attention-deficit hyperactivity disorder symptoms were identified by the Adult Attention-Deficit/Hyperactivity Disorder Self-Report Scale, Short Form-36 and also Hospital Anxiety and Depression Scale were conducted. According to the Adult Attention-Deficit/Hyperactivity Disorder Self-Report Scale scores primary dysmenorrhea patients had a significantly higher rate compared to the control group. In bivariate analysis, Adult Attention-Deficit/Hyperactivity Disorder Self-Report Scale scores were found to have an association with Short Form-36 physical and mental component scores, anxiety and depression scores. Symptoms of attention-deficit hyperactivity disorder may be confronted in primary dysmenorrhea patients. © 2021 Ondokuz Mayis Universitesi. All rights reserved.Öğe Can We Use Placental Growth Factor-Based Tests to Assess Women With Suspected Pre-eclampsia?(Aras Part Medical Int Press, 2019) Sagsoz, Nevin…Öğe Comparison of Epidural Ropivacaine 0.2% and Ropivacaine 0.2% in Combination with Sufentanil 0.75 ?g mL-1 for Postcaesarean Analgesia(Kare Publ, 2008) Kaya, Tahsin; Buyukkocak, Unase; Basar, Hulya; Sagsoz, NevinAnalgesic techniques after c-section must be effective producing early mobilisation to enable mothers to care effort their babies. In this study, the comparison of ropivacaine 0.2% alone, with ropivacaine 0.2%+sufentanil 0.75 microg mL-1 for patient controlled epidural analgesia (PCEA) was aimed. Fifty women (ASA-I) were enrolled in the study. All patients had combined spinal-epidural anaesthesia. Infusion of analgesic solutions was started when sensory level decreased by two dermatome levels. The patients randomly assigned, into two groups (n=25). In Group-I, ropivacaine 0.2% and sufentanil 0.75 microg mL-1, in Group-II, ropivacaine 0.2% alone were applied (bolus 1.25 mL, lockout 30 min, with 2.5 mL h-1 background infusion). Pain (Visual Analog Scale), motor blockage (Bromage scale) and sedation (Four point scale) were evaluated during 24 hours after Caesarean, using the scales of visual analogue, bromage, and four-point, respectively. Haemodynamic and respiratory parameters, side effects, total drug consumption and additional analgesic need, were recorded. Statistical analysis included student-t, chi-square, and Mann Whitney U tests. There was no difference in demographic data, sedation scores, haemodynamic and respiratory parameters, between the groups. Motor block and pain scores were significantly higher in Group-II than in Group-I at 2 and 4. h. Total drug consumption was 65.24+/-4.20 mL for Group-I and 81.1+/-6.44 mL for Group-II, (P<0.05). Four patients in Group-I and 21 patients in Group-II received additional analgesic. Pruritus was observed more frequently in Group-I. The addition of sufentanil 0.75 microg mL-1 to ropivacaine 0.2% for PCEA after Caesarean led to more effective analgesia and less motor weakness when compared to ropivacaine 0.2% alone, especially during early postoperative period.Öğe Does COVID-19 Infection Affect Female Reproductive System?(Aras Part Medical Int Press, 2022) Sagsoz, Nevin[Abstract No tAvailable]Öğe Effects of hormone replacement therapy on renal artery Doppler indices in women with natural menopause(Galenos Yayincilik, 2006) Yucel, Aykan; Kara, Simay Altan; Noyan, Volkan; Sagsoz, Nevin; Cil, Aylin PelinObjective: The aim of our study was to evaluate the effects of three different hormone replacement therapy (HRT) regimens on renal vasculature determined by renal artery Doppler ultrasonography indices in natural menopause. Design: Thirty three postmenopausal women were randomly assigned to receive 0.625 mg conjugated equine estrogen (CEE) + 5 mg medroxyprogesterone acetate (MPA) (Group I), 2 mg estradiol valerate (Group II) or 2.5 mg Tibolon (Group III), respectively. Doppler ultrasound of the left renal interlobar artery was performed for each patient before the beginning and after 70 days of each hormone replacement therapy (HRT). Setting: Kirikkale University, School of Medicine, Department of Gynecology and Obstetrics, and Department of Radiology, Kirikkale, Turkey. Main outcome measures: Renal interlobar artery Doppler indices before and after therapy. Results: Of the thirty three patients, there were 11, 7 and 9 patients who completed the study in group I, II and III, respectively. The mean age of 27 patients who completed the study was 49.44 +/- 4.07. The baseline pulsatility index (PI) and resistivity index (RI) values of the three groups were similar. After 70 days of treatment, there were statistically significant decrease in RI values of group III (p< 0.001) and RI (p=0.047) and PI (p=0.028) values of group II while statistically significant change was not obtained in group I after treatment. Conclusion: Although we may conclude from the results of this small sample sized study that tibolon and estradiol valerate may have favorable effects on renal blood flow and MPA combined with CEE may attenuate the estrogen-induced vascular effects in natural menopause, well designed studies with more patients and long term follow-up are needed to strengthen this judgment.Öğe Effects of L-carnitine on oxidative stress parameters in oophorectomized rats(Taylor & Francis Ltd, 2017) Canbolat, Emel Peri; Sagsoz, Nevin; Noyan, Volkan; Yucel, Aykan; Kisa, UclerAims: The aim of this study was to investigate the antioxidant effects of L-carnitine on the oxidative stress parameters in oophorectomized rats. Methods: Twenty-four female albino Wistar rats were used. Rats were divided into four groups: laparotomy-only (LOSALINE) group, oophorectomy plus L-carnitine 100 mg/kg/day (OXL100) group, oophorectomy plus L-carnitine 500 mg/kg/day (OXL500) group, and oophorectomy-only (OXSALINE) group. Experimental protocol was started on day 21 post-castration. Various dosage forms of L-carnitine or isotonic saline were administered intraperitoneally for 14 consecutive days. Nitric oxide (NO), malondialdehyde (MDA), total antioxidant status (TAS), total oxidative stress (TOS) and oxidative stress index (OSI) were evaluated in the tissues including kidney, liver and heart, and sera. Result(s): In the heart tissue samples, there was no difference in the levels of NO, OSI and TOS between the groups. However, MDA levels in OXSALINE group were significantly higher than OXL500 group. On the other hand, there was no statistically significant differences between the groups in terms of levels of NO, MDA, TAS, TOS and OSI in liver, kidney and sera samples. Conclusion(s): Levels of MDA in the heart tissue were significantly higher in OXSALINE group compared to OXL500 group. Thus, it may be suggested that L-carnitine reduces oxidative stress at least in the heart of oophorectomized rats. (C) 2016 Alexandria University Faculty of Medicine. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Öğe EFFECTS OF OBESITY ON THE SERUM BMP15, GDF9, AND KISSPEPTIN CONCENTRATIONS IN WOMEN OF REPRODUCTIVE AGE(Soc Medical Biochemists Serbia, 2023) Arikan, Funda Bulut; Sagsoz, NevinBackground: As BMP15, GDF9, and kisspeptin all play critical roles in folliculogenesis and fertilization, investigating the possible relationship between obesity and these three factors could prove crucial in relation to understanding the role of obesity in infertility. Thus, the present study sought to determine the effects of obesity on the serum BMP15, GDF9, and kisspeptin concentrations in women of reproductive age. Methods: Ninety female participants were equally divided into three groups: class-1 obese (n=30), class-2 obese (n=30), and normal weight (control; n=30). The participants' serum BMP15, GDF9, and AMH concentrations were measured. Moreover, the serum kisspeptin concentrations were evaluated in the class-1 obese and control groups by means of the enzyme-linked immunosorbent assay (ELISA) method while the participants were in their menstrual period. Results: The serum BMP15 and kisspeptin concentrations were found to be much higher in the control group than in both obese groups (p=0.001 and p=0.01, respectively). While the GDF9 concentration exhibited a statistically significant positive correlation with age, the BMP15 concentration exhibited a positive correlation with the kisspeptin and LH concentrations in the control group. In addition, a positive correlation was identified between the BMP15 concentration and both age and the glucose level and a negative correlation with the insulin level in both the obese groups. Conclusions: Obesity appears to reduce the serum BMP15 and kisspeptin concentrations in obese women of repro ductive age. This reduction may represent a milestone in reproductive dysfunction and may be used to predict the success of infertility treatment in obese women.Öğe Mature cystic teratoma mimicking meningomyelocele(Springer, 2021) Balci, Mahi; Yuksel, Ulas; Akkaya, Merva Aydemir; Akkaya, Suleyman; Sagsoz, NevinTeratomas are benign germ cell tumors originating from at least two germ layers, mostly of ectodermal and mesodermal origin. Mature teratomas are the most common subtype and develop from well-differentiated germ cells. Although the location is extragonadal in infants and young children, gonadal involvement occurs in adults. Midline defects can be diagnosed on prenatal imaging. In this case report, a newborn with mature cystic teratoma and a prenatal lumbar midline closure defect was presented. The perinatal preliminary diagnosis was meningomyelocele. However, a cystic sac containing exophytic solid tumoral tissues approximately 5 x 5 x 3 cm in size was seen macroscopically in the lumbar region after the birth, and this tumor was totally resected. After tumor excision, spina bifida aperta and vertebral exophytic bony tissue compatible with diastematomyelia were observed at the bottom of the surgical field and were totally resected. In the short-term follow-up, no additional problem occurred. The histopathological diagnosis was mature cystic teratoma. In conclusion, extragonadal teratoma accompanying diastematomyelia could easily be mistaken for meningomyelocele or other common malformations. Perinatal diagnosis should be provided using radiodiagnostic methods, and total surgical excision and accurate pathological diagnosis are essential to avoid the risk of recurrence.Öğe Plasma lipocalin-2 levels in pregnancy(Wiley-Blackwell, 2012) Cesur, Semra; Yucel, Aykan; Noyan, Volkan; Sagsoz, NevinObjective. To evaluate plasma levels of lipocalin-2, which is a novel adipokine associated with obesity and insulin resistance, in pregnant women. Design. Prospective casecontrol study. Setting. University hospital. Population. Pregnant women with pre-pregnancy body mass index >25kg/m2 (overweight; n=29) and body mass index <25kg/m2 (n=27), whose gestational ages were between 24 and 28weeks, as study groups and nonpregnant control women with body mass index <25kg/m2 (n=29). Methods. Plasma lipocalin-2 levels, fasting plasma glucose and fasting plasma insulin levels; homeostasis model assessment insulin resistance index and fasting plasma glucose/fasting plasma insulin ratio were measured for each subject. Main Outcome Measures. Comparisons among the groups and correlations for lipocalin-2 and the parameters of insulin resistance. Results. Plasma lipocalin-2 levels among the pregnant women were significantly higher than those of the control group (p<0.001 for both group comparisons). Lipocalin-2 levels were significantly higher in the group with pre-pregnancy body mass index >25kg/m2 compared with the group with pre-pregnancy body mass index <25kg/m2 (p=0.003). Lipocalin-2 levels were positively correlated with homeostasis model assessment insulin resistance index and fasting plasma insulin and negatively correlated with fasting plasma glucose/fasting plasma insulin ratio in both pregnant groups. Conclusions. Lipocalin-2 was found to be higher in pregnant women, especially when pre-pregnancy body mass index was >25kg/m2, and it was correlated with markers of insulin resistance.Öğe Serum kisspeptin, leptin, neuropeptide Y, and neurokinin B levels in adolescents with polycystic ovary syndrome(Walter De Gruyter Gmbh, 2022) Guzelkas, Ismail; Orbak, Zerrin; Doneray, Hakan; Ozturk, Nurinnisa; Sagsoz, NevinObjectives Polycystic ovary syndrome (PCOS) is characterized by ovarian dysfunction, clinical and/or biochemical hyperandrogenism, and polycystic ovaries. Its pathogenesis is still unclear. This study aimed to investigate the relationship between kisspeptin, leptin, neuropeptide Y (NPY), and neurokinin B (NKB) levels for evaluating the pathogenesis of PCOS. Methods Levels of these parameters were analyzed in 20 patients with PCOS, and 16 healthy adolescents. Results Serum NPY levels were significantly higher in the obese and non-obese PCOS group (p<0.01). There was a negative correlation between the kisspeptin and the NKB levels (p<0.01) in the PCOS group but not in the control group. This negative correlation was also found in both PCOS groups (p<0.01). In the obese PCOS group, serum kisspeptin levels were significantly lower than the control and non-obese PCOS groups (p<0.05) although serum leptin and NPY levels were significantly higher in the obese PCOS group (p<0.01). Conclusions The high NPY levels in both obese and non-obese patients with PCOS indicate that NPY plays a role in the pathogenesis independently from obesity. Significantly high leptin and low kisspeptin levels in the obese PCOS group suggested that they may be associated with obesity rather than PCOS.Öğe Serum paraoxonase 1 activity, asymmetric dimethylarginine levels, and brachial artery flow-mediated dilatation in women with polycystic ovary syndrome(Elsevier Science Inc, 2011) Soyman, Zeynep; Noyan, Volkan; Tulmac, Murat; Yucel, Aykan; Sagsoz, Nevin; Bayrak, Tulin; Cakir, ErdincObjective: To evaluate endothelial function via serum asymmetric dimethylarginine (ADMA) levels, paraoxonase 1 (PON1) activity, and brachial artery flow-mediated dilatation (FMD) in women with polycystic ovary syndrome (PCOS). Design: Prospective case-control study. Setting: University hospital. Patient(s): Thirty patients with PCOS with a mean age of 24.33 +/- 4.50 years and 30 healthy controls matched for body mass index (BMI) and age. Intervention(s): Endothelial function was assessed biochemically with serum ADMA levels and serum PON1 activity and functionally with brachial artery FMD by ultrasonography. Main Outcome Measure(s): Serum ADMA levels, serum PON1 activity, brachial artery FMD, hormonal and biochemical parameters. Result(s): Patients with PCOS had higher levels of free testosterone and insulin, and higher waist-hip ratio and Ferriman Gallwey scores when compared with the controls. Fasting glucose and homeostasis model assessment of insulin resistance were not different between the groups. There was no statistically significant difference in ADMA levels between two groups. Serum PON1 activity and brachial artery FMD were statistically significantly lower in women with PCOS. There was negative correlation between ADMA and PON1 in patients with PCOS. Conclusion(s): Serum PON1 activity and brachial artery FMD, as markers of endothelial dysfunction and cardiovascular risk, were statistically significantly lower in women with PCOS compared with healthy controls matched for age and BMI. Endothelial dysfunction may be seen at earlier ages in patients with PCOS. (Fertil Steril (R) 2011;95:1067-72. (C) 2011 by American Society for Reproductive Medicine.)Öğe The Effect of Varenicline on The Ovarian Follicle and Hormones, and Endometrial Thickness In An Experimental Model(Yuzuncu Yil Universitesi Tip Fakultesi, 2023) Bulanik, Murat; Sagsoz, Nevin; Bakirci, Şükrü; Yeral, Mahmut Ilkin; Atasoy, Pinar; Boyunaga, HakanIt was aimed to evaluate the histological, biochemical, and hormonal changes in the reproduct ive system of varenicline exposed female rats in an experimental model. Forty female rats were randomized into 4 groups. (1) Control group (n = 10); (2) Smoking group (smoking exposure 30 minutes twice a day) (n = 8); (3) Varenicline group (1 ml/kg); (4) Smoking+Varenicline (varenicline treatment (1 ml/kg) after smoking exposure (30 minutes twice a day). After the experiment, ovarian follicle count and endometrial thickness were examined; biochemical hormones-include Anti-mullerian hormone-and free oxygen radical levels were calculated. AMH levels were significantly lower in group 4 than in group 1 (p = 0.049). Group 2 and group 3 were significantly lower than group 1 (p = 0.038, p = 0.045, respectively). There was no statistically significant difference in endometrial thickness and free oxygen radical levels between the groups (p>0.05). We found that varenicline is related to reduced AMH and PRMF levels. The difference in endometrial thickness between the groups was not detected. These findings show that varenicline may harm ovarian functions. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.Öğe THE EFFECTS OF THE COMBINED ORAL CONTRACEPTIVES ON THE BONE MINERAL DENSITY OF REPRODUCTIVE AGE WOMEN(Galenos Yayincilik, 2005) Yucer, Gokcen; Yucel, Aykan; Noyan, Volkan; Bostanci, M. Suhha; Sagsoz, NevinObjective: To determine the effects of combined oral contraceptives (COC's) on bone mineral density of women after 12 month treatment. Design: Comparison of the Bone Mineral Density (BMD) and serum Ca+2, osteocalcin, alkaline phosphatase, Vitamin D3 and urinary OH-proline levels. Setting: Kirikkale University Medical Faculty Hospital. Patients: Fifty patients of ages < 40 years who took combined oral contraceptive for 12 months. Intervention: Bone Mineral Density Measurements and comparison of these values at the beginning and after 12 month of COC treatment. Results: The serum level of Ca+2 significantly increased [p<0.05] at the time of observation in comparison to the basal level. The urinary excretion of OH-proline over 12 months significantly decreased [p<0.05] at the end of study. At 12th month, no significant difference was detected in lumbar, femur, and distal ulna-radius BMD values in comparison with basal values. The BMD of proximal ulna-radius significantly increased [p<0.05] at the end of twelve months in comparison to basal content. Conclusions: The contraceptive pill containing 20 mu g Ethinyl estradiol + 100 mu g Levonorgestrel has beneficial effects on the bone turnover and bone mineral density at proximal ulna-radius.
