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    Development and characterization of orodispersible films containing amlodipine besylate and rosuvastatin calcium based on electrospun fibers
    (Elsevier, 2024) Muratoglu, Semsi; Inal, Murat; Gulsun, Tugba; Sahin, Selma
    Amlodipine besylate (AML) and rosuvastatin calcium (ROS) are commonly used in the treatment of cardiovascular diseases such as hypertension, dyslipidemia, and coroner artery disease. Orodispersible films (ODFs) have received considerable attention in pharmaceutical development studies as they significantly improve patient compliance. The aim of this study was to develop an ODF formulation containing AML and ROS simultaneously as an electrospun fiber fixed dose preparation. Polymer solutions were evaluated for surface tension, viscosity, and conductivity properties. Preformulation studies were conducted to optimize the electrospinning process. Two different formulations, designated ODF-1 and ODF-2 were the focus of this study. Fiber characterization studies, such as scanning electron microscopy (SEM), Fourier transform-infrared spectroscopy (FT-IR), mechanical properties were performed to assess these two formulations. Furthermore, ODF characterizations, such as disintegration and wetting time, homogeneity of contents, and in vitro dissolution studies were carried out. All formulations exhibited suitable mechanical properties, facilitating easy storage and handling. ODF characterizations revealed rapid disintegration and wetting times for all formulations with over 90 % dissolution in 5 min for both AML and ROS. The overall evaluation of all experiments suggests that ODF-1 may more desirable mechanical properties and a more stable dissolution profile compared to ODF-2. Furthermore, individual ODFs loaded with AML or ROS (AML-ODF-1 and ROS-ODF-1) were prepared by ODF-1 preparation method and then characterized to compare the results with fixed dose ODF results. In conclusion, a promising formulation strategy has been developed to obtain an electrospun fiber ODF formulation containing AML and ROS that is reproducible and suitable for industrial production.
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    Electrospun nanofiber drug delivery systems and recent applications: An overview
    (Elsevier, 2024) Muratoglu, Semsi; Inal, Murat; Akdag, Yagmur; Gulsun, Tugba; Sahin, Selma
    Fiber technology plays a significant role in advancing drug research. While developing drug delivery systems, nanofiber technology has gained importance due to its high surface area to volume ratio and porosity. The most preferred nanofiber production method is the electrospinning method. This review focuses on electrospun nanofiber drug delivery systems, including analysis of critical process parameters affecting electrospinning and nanofiber properties. Moreover, the design strategies for nanofiber drug delivery systems are explored, including equipment preferences and design types. Given to these design strategies, it is possible to design either nanofiber mat or nanofiber itself. It has been shown that a tailor-made drug delivery system can be prepared using axialbased nozzles and other equipment options. In addition, the prominent features and usage areas of frequently used polymers are mentioned. General characterization studies of post-production nanofibers are discussed. Examples of areas of use for pharmaceutical purposes are presented. Finally, drug release kinetics were evaluated on electrospun nanofiber drug delivery systems. As a result of exhaustive evaluations, various effective applications in the literature have been shown to achieve remarkable results such as drug release manipulation, drug targeting, self-assembling formulation strategies. Therefore, it is clear that in the field of electrospun nanofiber technology, it is possible to modify all the process options and develop a unique drug delivery product, thanks to a comprehensive evaluation of the critical quality parameters of the drug product.