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Öğe 1,25(OH)(2)D-3 and specific IgE levels in children with recurrent tonsillitis, and allergic rhinitis(Elsevier Ireland Ltd, 2013) San, Turhan; Muluk, Nuray Bayar; Cingi, CemalObjectives: We investigated 1,25-dihydroxyvitamin D-3 [1,25(OH)(2)D-3] and specific immunoglobulin E (IgE) levels in children with recurrent tonsillitis (RT) plus allergic rhinitis (AR). Methods: Thirty children with RT + AR were included in the study group, and 30 healthy children comprised the control group. AR-related symptoms were determined using a symptom scale. 1,25(OH)(2)D-3 and specific IgE measurements were made in both groups. Results: The 1,25(OH)(2)D-3 value was significantly lower in the RT + AR group than in the control group. Specific IgE (mixed) panels were in normal limits in both groups; whereas specific IgE (mixed) grass pollen panel value of RT + AT group was significantly higher than that of the control group. Higher nasal itching, nasal obstruction, and concha edema scores were related to significantly higher specific IgE values for the (mixed) grass pollen panel, whereas higher sneeze scores were related to higher specific IgE values for the (mixed) pediatric panel. Conclusions: Children with grass pollen allergy may not be exposed to sufficient sunlight. With reduced 1,25(OH)(2)D-3, T helper cells may increase, and allergic response also increases. As allergic events increased, these children did not go outside and thus lacked sun exposure. This vicious cycle must be broken, and children with RT + AR should have sunlight exposure to increase 1,25(OH)(2)D-3 levels. (C) 2013 Elsevier Ireland Ltd. All rights reserved.Öğe Efficacy of Curcumin in the healing of paracentesis in rats(Elsevier Ireland Ltd, 2014) Birdane, Leman; San, Turhan; Muluk, Nuray Bayar; Burukoglu, Dilek; Cingi, CemalObjectives: The present study was designed to investigate the possible beneficial effect of Curcumin (CMN) in healing of paracentesis in terms of wound thickness, sclerosis and closure by histological evaluation. To evaluate the efficacy of CMN, paracentesis was performed experimentally in the rats; and the results were presented histologically. Methods: Sixteen, each 270-310 g weighted, healthy Sprague-Dawley female rats were included into the study. In both groups, paracentesis was performed into the eardrum bilaterally. In Group 1 (Paracentesis + Saline Group), saline drop was applied; and in Group 2 (Paracentesis + Curcumin group), Curcumin drop treatment was applied. Paracentesis area did not healed bilaterally in two rats (one in Group 1 and one in Group 2). Therefore, these two rats were excluded from the study. Histological examination performed in 14 rats and 28 temporal bones on the 15th day after the completion of drop treatment and closure of the paracentesis-area and wound healing were evaluated according to the histological examination criteria: Thickening of the tympanic membrane (ThicTM); and sclerosis. Results: Both tympanic membrane thickening and sclerosis values of Paracentesis + Curcumin Group (Group 2) were significantly lower than those of the Paracentesis + Saline Group's (median: 2.0) (p = 0.001). Histological examination by light microscopy showed that in Paracentesis + Curcumin Group (Group 2), the structure of the tympanic membrane is near to the normal and decreased sclerosis was observed in connective tissue. Whereas in Paracentesis + Saline Group (Group 1), tympanic membrane thickening and connective tissue sclerosis were observed. Conclusions: Curcumin improves wound healing process in paracentesis of TM. By using Curcumin drops, the closured paracentesis area was observed near to the normal eardrum; and thickness of the TM and sclerosis were less than the control, showing the improved healing at 15th day. The possible mechanisms may be anti-inflammatory effect, improving collagen deposition, and increasing fibroblast and vascular density in wounds thereby enhancing impaired wound healing. (C) 2013 Elsevier Ireland Ltd. All rights reserved.Öğe Evaluation of Patient Satisfaction with Different Hearing Aids: A Study of 107 Patients(Sage Publications Inc, 2017) Ulusoy, Seckin; Muluk, Nuray Bayar; San, Turhan; Cingi, CemalWe retrospectively investigated patient satisfaction with different types of hearing aids in 107 patients60 males and 47 females, aged 8 to 84 years (mean: 53.8)with unilateral or bilateral hearing loss, each of whom used two different hearing devices for at least 3 years per device. The International Outcome Inventory for Hearing Aids, Turkish edition (IOI-HA-TR) was used to evaluate satisfaction levels; we also calculated our own total individual subjective satisfaction (TISS) scores. We divided 16 different hearing devices into two types: device 1 and device 2; on average, device 2 had more channels, a lower minimum frequency, and a higher maximum frequency. We found that the IOI-HA-TR scores and TISS scores were higher and usage time was greater during device 2 use, and that there was a positive correlation between IOI-HA-TR and TISS scores. A total of 69 patients (64.5%) used device 2 for more than 8 hours per day, while 38 patients (35.5%) used it for 4 to 8 hours per day during the final 2 weeks of the trial. In contrast, 40 patients (37.4%) used device 1 for more than 8 hours, 50 (46.7%) used it for 4 to 8 hours, and the remaining 17 (15.9%) used it for less than 4 hours; the difference in the duration of use of the two devices was statistically significant (p < 0.001). Younger patients and patients with more education were more satisfied with their devices than were older patients and those who were not as well educated. We conclude that devices with good technologic features such as more channels, a lower minimum frequency, and a higher maximum frequency result in better hearing. Also, based on the age difference that we observed, we recommend that psychological support be provided to older patients with aided hearing to enhance their mental health and quality of life.Öğe Fat-plug myringoplasty of ear lobule vs abdominal donor sites(Springer, 2015) Acar, Mustafa; Yazici, Demet; San, Turhan; Muluk, Nuray Bayar; Cingi, CemalThe purpose of this study is to compare the success rates of fat-graft myringoplasties harvesting adipose grafts from different donor sites (ear lobule vs abdomen). The clinical records of 61 patients (24 males and 37 females) who underwent fat-plug myringoplasty (FPM) were reviewed retrospectively. Fat from ear lobule (FEL) and abdominal fat were used as graft materials. The impact of age, gender, systemic diseases, topography of the perforation, utilization of fat graft materials of different origin on the tympanic membrane closure rate and the effect of FPM on hearing gain was analyzed. Our tympanic membrane (TM) closure rate was 82 %. No statistical significant difference was observed regarding age, gender, comorbidities (septal deviation, hypertension and diabetes mellitus) or habits (smoking). Posterior TM perforations had significantly lower healing rate. The change in TM closure rate considering different adipose tissue donor sites was not statistically significant. The hearing gain of the patients was mostly below 20 dB. Fat-plug myringoplasty (FPM) is a safe, cost-effective and easy operation for selected patients. Abdominal fat graft is as effective as ear lobe fat graft on tympanic membrane healing, has cosmetic advantages and should be taken into consideration when planning fat as the graft source.Öğe Is there a relationship between cribriform plate dimensions and septal deviation angle?(Springer, 2014) Saylisoy, Suzan; Acar, Mustafa; San, Turhan; Karabag, Aral; Muluk, Nuray Bayar; Cingi, CemalThe aim of this retrospective study was to investigate the relationship between cribriform plate (CP) dimensions and septal deviation degree. Coronal paranasal CT scans of 99 patients were reviewed. We measured depth and width of cribriform plate on both sides and compared with septal deviation side and septal deviation degree. Deviation angles were 6.85 +/- A 1.47A degrees for right deviations; and 7.11 +/- A 1.63A degrees for the left deviations. The mean depth of CP was 5.08 +/- A 1.57 mm at the right side and 5.06 +/- A 1.59 mm at the left side; and the mean width of CP was found 4.71 +/- A 1.36 mm at the right side and 4.56 +/- A 1.51 mm at the left side. When CP dimensions were evaluated according to the septal deviation side, mean width of CP was 4.69 +/- A 1.36 mm at ipsilateral side (deviated side); and 4.58 +/- A 1.51 mm at the contralateral side. The mean depth of CP was 4.9 +/- A 1.56 mm at the ipsilateral side (deviated side); and 5.22 +/- A 1.58 mm at the contralateral side. The CP depth at the contralateral side was significantly higher than that of the ipsilateral side (deviated side). In right SD, ipsilateral and contralateral CP depth increased. As deviation angle increased, ipsilateral and contralateral CP width, right and left CP width increased. Ipsilateral and contralateral CP width; and additionally ipsilateral and contralateral CP depth increased together. In other words, right and left CP width; and CP depth increased simultaneously. It is well known that the higher incidence of intracranial penetration is on the side where the position of the ethmoid roof (ER) is lower. The presence of septal deviation, the possibility of the deeper CP at the contralateral side should be taken into consideration to avoid iatrogenic injury.Öğe Nasal septal body and inferior turbinate sizes differ in subjects grouped by sex and age(Int Rhinologic Soc, 2014) San, Turhan; Muluk, Nuray Bayar; Saylisoy, Suzan; Acar, Mustafa; Cingi, CemalObjectives: To compare the size of the nasal septal body (SB) and inferior turbinate (IT) of subjects grouped by sex and age. Method: We measured SB and IT areas (in cm(2)) bilaterally in computed tomography (CT) sections of 150 paranasal sinuses from 72 males and 78 females. Results:The right and left SB areas were smaller in females than in males. In the <= 25-year-old group, the right IT (RIT) was significantly smaller in females than in males. In the 26-35 and 46-45 age groups, the right SB (RSB) was significantly smaller in females than in males. Conclusion: The nasal SB may play a role in nasal physiology similar to a turbinate and help support optimal airflow. The vascular and glandular structures of the SB should be investigated in detail, and minimal invasive procedures should be performed in nasal surgery to avoid damaging essential structures.Öğe Reply to the letter to the editor concerning: 'Fat-plug myringoplasty of ear lobule vs abdominal donor sites'(Springer, 2017) Acar, Mustafa; Yazici, Demet; San, Turhan; Muluk, Nuray Bayar; Cingi, Cemal…
