Yazar "Selcuk, M. L." seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    Comparison of the Morphometric Features of the Left and Right Horse Kidneys: A Stereological Approach
    (Wiley, 2013) Bolat, D.; Bahar, S.; Tipirdamaz, S.; Selcuk, M. L.
    The aims of this study were to determine the total volume of the horse kidney and volume fractions of its functional subcomponents (cortex, medulla, renal pelvis) using stereological methods and investigate any possible difference in the functional subcomponents of the right and left kidneys that may arise from differences in shape. The study was carried out on the kidneys of 5 horses of different breed and sex. The weight of the kidneys was measured by a digital scale, and kidney volume was calculated by Archimedes' principle. Total kidney volume and volume fractions of subcomponents of the right and left kidneys were estimated by the Cavalieri's principle. The weights of the right and left kidneys were 550 +/- 25g and 585 +/- 23g, respectively. The volumes of the right and left kidneys estimated using the Cavalieri method were 542 +/- 46ml and 581 +/- 29ml. The relative organ weight of the kidneys was calculated as 1:330. The densities of the right and left kidneys were determined to be 1.01 and 1.00, respectively. The mean volume fractions of the cortex, medulla and renal pelvis were determined as 55.6, 42.7 and 1.7 in both kidneys. No statistically significant difference existed between morphometric data pertaining to the right and left kidneys (P>0.05). To determine precisely whether differences in shape cause any difference in the functional subcomponents of the right and left kidneys requires further investigation of differences in the number of microscopically functional unit of the kidney such as renal glomeruli and nephrons.
  • Küçük Resim
    Öğe
    Stereological and biochemical evaluation of diclofenac-induced acute nephrotoxicity in rats
    (Ecole Nationale Veterinaire Toulouse, 2013) Bolat, D.; Selcuk, M. L.
    The aim of this study was to evaluate the effects of diclofenac-induced acute nephrotoxicity using stereological and biochemical parameters in rats. For that, 20 male Wistar rats allotted in 4 equal groups were intraperitoneally injected by 0, 10, 50 and 100 mg/kg diclofenac, respectively and 8 hours after injection, blood serum samples were collected for assessment of urea, creatinine, fibrinogen, antithrombin III, malondialdehyde (MDA), nitric oxide, vitamin C and beta-carotene concentrations and amine deaminase (ADA) and superoxide dismutase (SOD) activities. After slaughtering, left kidneys were stereologically evaluated. Despite slight but more often not significant variations especially observed in rats treated with 50 mg/kg diclofenac, stereological renal parameters, oxidative stress markers and coagulation markers were considered to be within usual values in rats. By contrast, significant and dose related increases in uraemia were evidenced in intoxicated animals. It was concluded that diclofenac-induced kidney damage cannot be evaluated by kidney stereological and serum oxidative stress parameters, however, more severe kidney damage may cause observable alterations in these parameters.